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    HYDROPHOBIC MONOMERS, HYDROPHOBICALLY-DERIVATIZED SUPPORTS, AND METHODS OF MAKING AND USING THE SAME
    14.
    发明申请
    HYDROPHOBIC MONOMERS, HYDROPHOBICALLY-DERIVATIZED SUPPORTS, AND METHODS OF MAKING AND USING THE SAME 审中-公开
    疏水性单体，疏水性衍生物的支持物及其制备方法和使用方法

    公开(公告)号：WO2010117598A2

    公开(公告)日：2010-10-14

    申请号：PCT/US2010/027978

    申请日：2010-03-19

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  RASMUSSEN, Jerald K. ,  KIPKE, Cary A. ,  HEMBRE, James I. ,  WICKERT, Peter D.

    Inventor： RASMUSSEN, Jerald K. ,  KIPKE, Cary A. ,  HEMBRE, James I. ,  WICKERT, Peter D.

    IPC: C07C233/09 ,  C08F20/54 ,  C08J9/08 ,  B01J20/285 ,  B01D71/56

    CPC classification number: B01J20/285 ,  B01D15/206 ,  B01D15/327 ,  B01D67/0006 ,  B01D67/0088 ,  B01D67/0093 ,  B01D69/125 ,  B01D71/56 ,  B01D2323/30 ,  B01D2325/38 ,  B01J20/286 ,  C07C237/22 ,  C08F20/54

    Abstract: A composition is disclosed comprising a hydrophobic monomer having the structure:CH 2 =CR 4 C(O)NHC(R 1 R 1 )(C(R 1 R 1 )) n C(O)XR 3 wherein n is an integer of 0 or 1; R 1 is independently selected from at least one of: a hydrogen atom, alkyls, aryls, and alkylaryls, wherein the alkyls, aryls, and alkylaryls have a total of 10 carbon atoms or less; R 3 is a hydrophobic group selected from at least one of: alkyls, aryls, alkylaryls and ethers, wherein the alkyls, aryls, alkylaryls and ethers have a total number of carbon atoms ranging from 4 to 30; R 4 is H or CH 3 ; X is O or NH. In some embodiments the hydrophobic monomer is derived from an amine or an alcohol (HXR 3 ) that has a hydrophilicity index of 25 or less. A polymerizable composition comprising the hydrophobic monomer is disclosed, which optionally may comprise a cross-linking monomer and/or a non-cross-linking monomer. This polymerizable mixture may be used to from hydrophobically-derivatized supports, which may be used in applications such as hydrophobic interaction chromatography.

    Abstract translation: 公开了一种组合物，其包含具有以下结构的疏水单体：CH 2 = CR 4 C（O）NHC（R 1 R 1）（C（R 1 R1））nC（O）XR 3，其中n为0或1的整数; R 1独立地选自氢原子，烷基，芳基和烷基芳基中的至少一个，其中烷基，芳基和烷基芳基总共具有10个或更少的碳原子; R3是选自烷基，芳基，烷基芳基和醚中的至少一种的疏水基团，其中烷基，芳基，烷基芳基和醚的总碳原子数范围为4-30; R4是H或CH3; X是O或NH。 在一些实施方案中，疏水性单体衍生自亲水性指数为25以下的胺或醇（HXR3）。 公开了包含疏水单体的可聚合组合物，其任选地可以包含交联单体和/或非交联单体。 该可聚合混合物可用于疏水衍生的载体，其可用于例如疏水相互作用层析的应用中。

    METHODS FOR PERFORMING IMMUNOLOGICAL ASSAYS
    15.
    发明申请
    METHODS FOR PERFORMING IMMUNOLOGICAL ASSAYS 审中-公开
    执行免疫测定的方法

    公开(公告)号：WO2003019134A2

    公开(公告)日：2003-03-06

    申请号：PCT/US2002/014602

    申请日：2002-05-09

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY

    Inventor： BERNATCHEZ, Stephanie F. ,  SWENSON, Barbara C. ,  HALVERSON, Kurt J. ,  PATIL, Sanjay L. ,  PRABHU, Anila ,  RASMUSSEN, Jerald K.

    IPC: G01N

    CPC classification number: G01N33/54393 ,  G01N33/54353

    Abstract: Methods for performing immunological assays are provided. The methods allow performing immunological assays with increased sensitivity, increased specificity, or both. Kits for performing immunological assays having increased sensitivity, increased specificity, or both, are also provided.

    Abstract translation: 提供了用于进行免疫学测定的方法，其使用吖内酯改性的聚合物底物，其中在免疫测定过程中吖内酯部分被筛选。 所述方法允许以增加的灵敏度，增加的特异性或两者进行免疫学测定。 还提供了用于进行具有增加的灵敏度，增加的特异性或两者的免疫测定的试剂盒。

    ARTICLES CONTAINING A CROSSLINKED GUANIDINYL-CONTAINING POLYMER AND USES THEREOF
    16.
    发明申请
    ARTICLES CONTAINING A CROSSLINKED GUANIDINYL-CONTAINING POLYMER AND USES THEREOF 审中-公开

    公开(公告)号：WO2021024075A1

    公开(公告)日：2021-02-11

    申请号：PCT/IB2020/056954

    申请日：2020-07-23

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY

    Inventor： VAIL, Andrew W. ,  RASMUSSEN, Jerald K. ,  SCHMITZ, Robert A.

    IPC: A01N47/44 ,  A01N25/10 ,  A01N25/34

    Abstract: An article, and method of use, wherein the article includes: a substrate; a cationic coating bound to the substrate, wherein the cationic coating includes a guanidinyl-containing polymer that is crosslinked on the substrate; wherein the guanidinyl-containing polymer is of the following Formula (I), wherein: R 3 is a H, C 1 -C 12 (hetero)alkyl, C 5 -C 12 (hetero)aryl, or Polymer; each R 4 is independently H, C 1 -C 12 (hetero)alkyl, or C 5 -C 12 (hetero)aryl; each R 5 is H, C 1 -C 12 (hetero)alkyl, C 5 -C 12 (hetero)aryl, or N(R 4 ) 2 ; Polymer is a residue of an aminopolymer chain; m is 1 or 2; and x is an integer of at least 1; and wherein the guanidinyl-containing polymer is crosslinked with an amine-reactive polyepoxy compound having pendant -OH groups.

    FUNCTIONALIZED COPOLYMERS AND USE THEREOF
    18.
    发明申请
    FUNCTIONALIZED COPOLYMERS AND USE THEREOF 审中-公开
    功能化共聚物及其用途

    公开(公告)号：WO2018048696A1

    公开(公告)日：2018-03-15

    申请号：PCT/US2017/049365

    申请日：2017-08-30

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY

    Inventor： VAIL, Andrew W. ,  COLAK ATAN, Semra ,  RASMUSSEN, Jerald K. ,  GRIESGRABER, George W. ,  BOTHOF, Catherine A.

    IPC: B01D67/00 ,  B01D69/02 ,  B01D71/56

    CPC classification number: B01D67/0093 ,  B01D69/02 ,  B01D71/56 ,  B01D2323/385 ,  B01D2325/14

    Abstract: An article that includes a functionalized copolymer and the use thereof, particularly in a process for binding biomaterials, such as in a process for separating aggregated proteins from monomeric proteins in a biological solution; wherein the article includes: a) a porous substrate; and b) a copolymer covalently attached to the porous substrate, the copolymer comprising a hydrocarbon backbone and a plurality of pendant groups attached to the hydrocarbon backbone, wherein 1) each of a first plurality of pendant groups comprises: (a) at least one acidic group or salt thereof; and (b) a spacer group that directly links the at least one acidic group or salt thereof to the hydrocarbon backbone by a chain of at least 6 catenated atoms; and 2) each of a second plurality of pendant groups comprises: (a) at least one acidic group or salt thereof; and (b) a spacer group that directly links the at least one acidic group or salt thereof to the hydrocarbon backbone by a chain of at least 6 catenated atoms; and wherein the first plurality of pendant groups are different than the second plurality of pendant groups; and wherein a mole ratio of the first plurality of pendant groups to the second plurality of pendant groups is in a range of 95:5 to 5:95.

    Abstract translation: 包括官能化共聚物的制品​​及其用途，特别是在用于结合生物材料的方法中，例如用于在生物溶液中将聚集的蛋白质与单体蛋白质分离的方法中; 其中所述制品包括：a）多孔基材; 和b）共价连接到所述多孔基材的共聚物，所述共聚物包含烃骨架和连接到所述烃骨架上的多个侧基，其中1）第一多个侧基中的每一个包含：（a）至少一个酸性 其组或盐; 和（b）通过至少6个连接原子的链将所述至少一个酸性基团或其盐直接连接到烃主链上的间隔基团; 和2）多个第二侧基中的每一个包含：（a）至少一种酸性基团或其盐; 和（b）通过至少6个连接原子的链将所述至少一个酸性基团或其盐直接连接到烃主链上的间隔基团; 并且其中所述第一多个侧面组不同于所述第二多个侧面组; 并且其中第一多个侧基与第二多个侧基的摩尔比在95:5至5:95的范围内。

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