公开(公告)号：AU784291B2

公开(公告)日：2006-03-02

申请号：AU5739300

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： ALLEN MICHAEL S ,  PREMCHANDRAN RAMIYA H ,  CHANG SOU-JEN ,  CONDON STEPHEN ,  DEMATTEI JOHN J ,  KING STEVEN A ,  KOLACZKOWSKI LAWRENCE ,  MANNA SUKUMAR ,  NICHOLS PAUL J ,  PATEL HEMANT H ,  PATEL SUBHASH R ,  PLATA DANIEL J ,  STONER ERIC J ,  TIEN JIEN-HEH J ,  WITTENBERGER STEVEN J

IPC: C07D215/14 ,  C07C33/03 ,  C07C43/303 ,  C07C47/22 ,  C07C57/04 ,  C07C68/06 ,  C07C69/96 ,  C07C269/06 ,  C07C271/12 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08

Abstract: The invention relates to a process for preparing carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or a substrate that can be reduced to obtain the same. €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR 1 -CH=CHCH 2 OC(O)-X-R 2 €ƒ€ƒ€ƒ€ƒ€ƒ(I)

公开(公告)号：HK1047089A1

公开(公告)日：2003-02-07

申请号：HK02107126

申请日：2002-09-26

Applicant: ABBOTT LAB

Inventor： ALLEN MICHAEL S ,  PREMCHANDRAN RAMIYA H ,  CHANG SOU-JEN ,  CONDON STEPHEN ,  DEMATTEI JOHN J ,  KING STEVEN A ,  KOLACZKOWSKI LAWRENCE ,  MANNA SUKUMAR ,  NICHOLS PAUL J ,  PATEL HEMANT H ,  PATEL SUBHASH R ,  PLATA DANIEL J ,  STONER ERIC J ,  TIEN JIEN-HEH J ,  WITTENBERGER STEVEN J

IPC: C07C20060101 ,  C07C68/06 ,  C07D20060101 ,  C07D215/14 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08

Abstract: The invention relates to a process for preparing carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or a substrate that can be reduced to obtain the same. €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR 1 -CH=CHCH 2 OC(O)-X-R 2 €ƒ€ƒ€ƒ€ƒ€ƒ(I)