公开(公告)号：JP2011088904A

公开(公告)日：2011-05-06

申请号：JP2010267057

申请日：2010-11-30

Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

Inventor： ALLEN MICHAEL S ,  PREMCHANDRAN RAMIYA H ,  CHANG SOU-JEN ,  CONDON STEPHEN ,  DEMATTEI JOHN J ,  KING STEVEN A ,  KOLACZKOWSKI LAWRENCE ,  MANNA SUKUMAR ,  NICHOLS PAUL J ,  PATEL HEMANT H ,  PATEL SUBHASH R ,  PLATA DANIEL J ,  ERIK J SUTOONAA ,  TIEN JIEN-HEH J ,  WITTENBERGER STEVEN J

IPC: C07D215/14 ,  C07B61/00 ,  C07C68/06 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08

CPC classification number: C07D215/14 ,  C07C68/06 ,  C07C69/96

Abstract: PROBLEM TO BE SOLVED: To provide a method for preparing quinoline-substituted carbonate and carbamate compounds which are important intermediates in the synthesis of a 6-O-substituted macrolide antibiotic material.
SOLUTION: The carbonate or carbamate derivative expressed by the formula: R
1 -CH=CHCH
2 OC(O)-X-R
2 (I) is obtained by coupling a haloquinoline with propargyl alcohol in the presence of a base and a palladium-based catalyst to form an alkynol, reducing it to make an alkenol and then reacting it with an acylation reagent.
COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 待解决的问题：提供一种制备喹啉取代的碳酸酯和氨基甲酸酯化合物的方法，其是合成6-O-取代的大环内酯类抗生素材料的重要中间体。 解决方案：由下式表示的碳酸酯或氨基甲酸酯衍生物：R 1 = CHCH 2 S（O）-XR 2 S / （I）通过在碱和钯基催化剂的存在下将卤代喹啉与炔丙醇偶联以形成炔醇，将其还原成烯醇，然后使其与酰化试剂反应而获得。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：CA2719425C

公开(公告)日：2014-08-12

申请号：CA2719425

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： ALLEN MICHAEL S ,  PREMCHANDRAN RAMIYA H ,  CHANG SOU-JEN ,  CONDON STEPHEN ,  DEMATTEI JOHN J ,  KING STEVEN A ,  KOLACZKOWSKI LAWRENCE ,  MANNA SUKUMAR ,  NICHOLS PAUL J ,  PATEL HEMANT H ,  PATEL SUBHASH R ,  PLATA DANIEL J ,  STONER ERIC J ,  TIEN JIEN-HEH J ,  WITTENBERGER STEVEN J

IPC: C07D215/14 ,  C07C33/03 ,  C07C43/303 ,  C07C47/22 ,  C07C57/04 ,  C07C68/06 ,  C07C69/54 ,  C07C69/96 ,  C07C271/08 ,  C07D215/12 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08

Abstract: The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or substrate that can be reduced to obtain the same.

公开(公告)号：DK1192139T3

公开(公告)日：2012-07-23

申请号：DK00942823

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： ALLEN MICHAEL S ,  CONDON STEPHEN ,  DEMATTEI JOHN J ,  KOLACZKOWSKI LAWRENCE ,  MANNA SUKUMAR ,  PATEL HEMANT H ,  PATEL SUBHASH R ,  PLATA DANIEL J ,  STONER ERIC J ,  TIEN JIEN-HEH J ,  NICHOLS PAUL J ,  PREMCHANDRAN RAMIYA H ,  CHANG SOU-JEN ,  KING STEVEN A ,  WITTENBERGER STEVEN J

IPC: C07D215/14 ,  C07C33/03 ,  C07C43/303 ,  C07C47/22 ,  C07C57/04 ,  C07C68/06 ,  C07C69/96 ,  C07C269/06 ,  C07C271/12 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08

公开(公告)号：PT1192139E

公开(公告)日：2012-07-20

申请号：PT00942823

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： KOLACZKOWSKI LAWRENCE ,  CHANG SOU-JEN ,  PLATA DANIEL J ,  STONER ERIC J ,  ALLEN MICHAEL S ,  PREMCHANDRAN RAMIYA H ,  KING STEVEN A ,  TIEN JIEN-HEH J ,  WITTENBERGER STEVEN J ,  CONDON STEPHEN ,  DEMATTEI JOHN J ,  MANNA SUKUMAR ,  NICHOLS PAUL J ,  PATEL HEMANT H ,  PATEL SUBHASH R

IPC: C07D215/14 ,  C07C33/03 ,  C07C43/303 ,  C07C47/22 ,  C07C57/04 ,  C07C68/06 ,  C07C69/96 ,  C07C269/06 ,  C07C271/12 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08

公开(公告)号：AT554071T

公开(公告)日：2012-05-15

申请号：AT00942823

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： ALLEN MICHAEL ,  PREMCHANDRAN RAMIYA ,  CHANG SOU-JEN ,  CONDON STEPHEN ,  DEMATTEI JOHN ,  KING STEVEN ,  KOLACZKOWSKI LAWRENCE ,  MANNA SUKUMAR ,  NICHOLS PAUL J ,  PATEL HEMANT ,  PATEL SUBHASH ,  PLATA DANIEL ,  STONER ERIC ,  TIEN JIEN-HEH ,  WITTENBERGER STEVEN

IPC: C07D215/14 ,  C07C33/03 ,  C07C43/303 ,  C07C47/22 ,  C07C68/06 ,  C07C69/96 ,  C07C269/06 ,  C07C271/12 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08

Abstract: The invention relates to a process for preparing carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or a substrate that can be reduced to obtain the same. €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR 1 -CH=CHCH 2 OC(O)-X-R 2 €ƒ€ƒ€ƒ€ƒ€ƒ(I)

公开(公告)号：AU784291B2

公开(公告)日：2006-03-02

申请号：AU5739300

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： ALLEN MICHAEL S ,  PREMCHANDRAN RAMIYA H ,  CHANG SOU-JEN ,  CONDON STEPHEN ,  DEMATTEI JOHN J ,  KING STEVEN A ,  KOLACZKOWSKI LAWRENCE ,  MANNA SUKUMAR ,  NICHOLS PAUL J ,  PATEL HEMANT H ,  PATEL SUBHASH R ,  PLATA DANIEL J ,  STONER ERIC J ,  TIEN JIEN-HEH J ,  WITTENBERGER STEVEN J

IPC: C07D215/14 ,  C07C33/03 ,  C07C43/303 ,  C07C47/22 ,  C07C57/04 ,  C07C68/06 ,  C07C69/96 ,  C07C269/06 ,  C07C271/12 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08

Abstract: The invention relates to a process for preparing carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or a substrate that can be reduced to obtain the same. €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR 1 -CH=CHCH 2 OC(O)-X-R 2 €ƒ€ƒ€ƒ€ƒ€ƒ(I)

公开(公告)号：HK1047089A1

公开(公告)日：2003-02-07

申请号：HK02107126

申请日：2002-09-26

Applicant: ABBOTT LAB

Inventor： ALLEN MICHAEL S ,  PREMCHANDRAN RAMIYA H ,  CHANG SOU-JEN ,  CONDON STEPHEN ,  DEMATTEI JOHN J ,  KING STEVEN A ,  KOLACZKOWSKI LAWRENCE ,  MANNA SUKUMAR ,  NICHOLS PAUL J ,  PATEL HEMANT H ,  PATEL SUBHASH R ,  PLATA DANIEL J ,  STONER ERIC J ,  TIEN JIEN-HEH J ,  WITTENBERGER STEVEN J

IPC: C07C20060101 ,  C07C68/06 ,  C07D20060101 ,  C07D215/14 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08

Abstract: The invention relates to a process for preparing carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or a substrate that can be reduced to obtain the same. €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR 1 -CH=CHCH 2 OC(O)-X-R 2 €ƒ€ƒ€ƒ€ƒ€ƒ(I)

公开(公告)号：CY1113070T1

公开(公告)日：2016-04-13

申请号：CY121100626

申请日：2012-07-13

Applicant: ABBOTT LAB

Inventor： ALLEN MICHAEL S ,  PREMCHANDRAN RAMIYA H ,  CHANG SOU-JEN ,  CONDON STEPHEN ,  DEMATTEI JOHN J ,  KING STEVEN A ,  KOLACZKOWSKI LAWRENCE ,  MANNA SUKUMAR ,  NICHOLS PAUL J ,  PATEL HEMANT H ,  PATEL SUBHASH R ,  PLATA DANIEL J ,  STONER ERIC J ,  TIEN JIEN-HEH J ,  WITTENBERGER STEVEN J

IPC: C07D215/14 ,  C07C33/03 ,  C07C43/303 ,  C07C47/22 ,  C07C57/04 ,  C07C68/06 ,  C07C69/96 ,  C07C269/06 ,  C07C271/12 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08

Abstract: Ηεφεύρεσηαφοράσεμιαμέθοδογιαπαρασκευήκινολινο-υποκατεστημένωνενώσεωνανθρακικούκαικαρβαμικού, οιοποίεςείναισημαντικάενδιάμεσαστηνσύνθεσητωναντιβιοτικών 6-O-υποκατεστημένουμακρολιδίου. Ημέθοδοςχρησιμοποιείτιςκαταλυόμενεςαπόμέταλλοαντιδράσειςσύζευξηςγιαναπαρέχειανθρακικόή καρβαμικότουτύπου (Ι) ή (II) ήυπόστρωμαπουμπορείναανάγεταιγιαναληφθούναυτά.

公开(公告)号：ES2385963T3

公开(公告)日：2012-08-06

申请号：ES00942823

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： ALLEN MICHAEL ,  PREMCHANDRAN RAMIYA ,  CHANG SOU-JEN ,  CONDON STEPHEN ,  DEMATTEI JOHN ,  KING STEVEN ,  KOLACZKOWSKI LAWRENCE ,  MANNA SUKUMAR ,  NICHOLS PAUL J ,  PATEL HEMANT ,  PATEL SUBHASH ,  PLATA DANIEL ,  STONER ERIC ,  TIEN JIEN-HEH ,  WITTENBERGER STEVEN

IPC: C07D215/14 ,  C07C33/03 ,  C07C43/303 ,  C07C47/22 ,  C07C57/04 ,  C07C68/06 ,  C07C69/96 ,  C07C269/06 ,  C07C271/12 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08

Abstract: Un procedimiento de preparación de un compuesto de fórmulaR1-CH>=CHCH2OC(O)-X-R2 (I),dondeR1 es quinolilo eventualmente substituido con uno o más de:(i) alquilo,(ii) alcoxi,(iii) arilo,(iv) nitro y(v) halo;R2 es alquilo C1-C10;X es -O- o -NR3; yR3 es hidrógeno, alquilo C1-C6 o arilo; o R2 y R3, tomados conjuntamente, forman un anillo aromático o noaromático, que comprende las etapas de:(a) preparación de un intermediario seleccionado entre:(i) R1-CºCCH2OR4, donde R4 es hidrógeno o un grupo hidroxi-protector;(ii) R1-CºC-CH2-OC(O)-X-R2;(b) reducción o desprotección de un intermediario obtenido en la etapa (a); y(c) copulación eventual del compuesto obtenido en la etapa (b) con un reactivo acilante.

公开(公告)号：CA2368768C

公开(公告)日：2011-10-11

申请号：CA2368768

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： ALLEN MICHAEL S ,  PREMCHANDRAN RAMIYA H ,  CHANG SOU-JEN ,  CONDON STEPHEN ,  DEMATTEI JOHN J ,  KING STEVEN A ,  KOLACZKOWSKI LAWRENCE ,  MANNA SUKUMAR ,  NICHOLS PAUL J ,  PATEL HEMANT H ,  PATEL SUBHASH R ,  PLATA DANIEL J ,  STONER ERIC J ,  TIEN JIEN-HEH J ,  WITTENBERGER STEVEN J

IPC: C07D215/14 ,  C07C68/06 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08

Abstract: The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.