公开(公告)号：CA2368768C

公开(公告)日：2011-10-11

申请号：CA2368768

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： ALLEN MICHAEL S ,  PREMCHANDRAN RAMIYA H ,  CHANG SOU-JEN ,  CONDON STEPHEN ,  DEMATTEI JOHN J ,  KING STEVEN A ,  KOLACZKOWSKI LAWRENCE ,  MANNA SUKUMAR ,  NICHOLS PAUL J ,  PATEL HEMANT H ,  PATEL SUBHASH R ,  PLATA DANIEL J ,  STONER ERIC J ,  TIEN JIEN-HEH J ,  WITTENBERGER STEVEN J

IPC: C07D215/14 ,  C07C68/06 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08

Abstract: The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.

公开(公告)号：CA2719425A1

公开(公告)日：2001-01-04

申请号：CA2719425

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： ALLEN MICHAEL S ,  PREMCHANDRAN RAMIYA H ,  CHANG SOU-JEN ,  CONDON STEPHEN ,  DEMATTEI JOHN J ,  KING STEVEN A ,  KOLACZKOWSKI LAWRENCE ,  MANNA SUKUMAR ,  NICHOLS PAUL J ,  PATEL HEMANT H ,  PATEL SUBHASH R ,  PLATA DANIEL J ,  STONER ERIC J ,  TIEN JIEN-HEH J ,  WITTENBERGER STEVEN J

IPC: C07D215/14 ,  C07C33/03 ,  C07C43/303 ,  C07C47/22 ,  C07C57/04 ,  C07C68/06 ,  C07C69/54 ,  C07C69/96 ,  C07C271/08 ,  C07D215/12 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08

Abstract: The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted marcolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or substrate that can be reduced to obtain the same.

公开(公告)号：CA2368768A1

公开(公告)日：2001-01-04

申请号：CA2368768

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： CONDON STEPHEN ,  CHANG SOU-JEN ,  DEMATTEI JOHN J ,  WITTENBERGER STEVEN J ,  PATEL HEMANT H ,  KING STEVEN A ,  PATEL SUBHASH R ,  MANNA SUKUMAR ,  NICHOLS PAUL J ,  STONER ERIC J ,  TIEN JIEN-HEH J ,  ALLEN MICHAEL S ,  KOLACZKOWSKI LAWRENCE ,  PLATA DANIEL J ,  PREMCHANDRAN RAMIYA H

IPC: C07C68/06 ,  C07D215/14 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08 ,  C07C33/03 ,  C07C57/04 ,  C07C269/06 ,  C07C271/12 ,  C07C47/22 ,  C07C43/303 ,  C07C69/96

Abstract: The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs meta l- catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.