公开(公告)号：WO2007140385A3

公开(公告)日：2007-12-06

申请号：PCT/US2007/069921

申请日：2007-05-30

Applicant: ABBOTT LABORATORIES ,  DART, Michael J. ,  CARROLL, William A. ,  FLORJANCIC, Alan S. ,  FROST, Jennifer M. ,  GALLAGHER, Megan E. ,  LI, Tongmei ,  NELSON, Derek W. ,  PATEL, Meena V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  RYTHER, Keith B. ,  TIETJE, Karin Rosemarie ,  KOLASA, Teodozyj

Inventor： DART, Michael J. ,  CARROLL, William A. ,  FLORJANCIC, Alan S. ,  FROST, Jennifer M. ,  GALLAGHER, Megan E. ,  LI, Tongmei ,  NELSON, Derek W. ,  PATEL, Meena V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  RYTHER, Keith B. ,  TIETJE, Karin Rosemarie ,  KOLASA, Teodozyj

IPC: C07D277/46 ,  C07D277/48 ,  C07D277/60 ,  C07D277/82 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/429 ,  A61P29/00

Abstract: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：EP1075466A1

公开(公告)日：2001-02-14

申请号：EP00914832.1

申请日：2000-03-06

Applicant: Abbott Laboratories

Inventor： CARROLL, William A. ,  CHEN, Yiyuan ,  DRIZIN, Irene ,  KERWIN, James, F. ,  MOORE, Jimmie, L.

IPC: C07D211/82 ,  C07D215/20 ,  C07D211/90 ,  A61K31/473

CPC classification number: C07D221/04 ,  C07C45/298 ,  C07D221/06 ,  C07C47/55

Abstract: Compounds of formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：EP2024349A2

公开(公告)日：2009-02-18

申请号：EP07797908.6

申请日：2007-05-31

Applicant: ABBOTT LABORATORIES

Inventor： DART, Michael J. ,  CARROLL, William A. ,  FLORJANCIC, Alan S. ,  FROST, Jennifer M. ,  GALLAGHER, Megan E. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  NELSON, Derek W. ,  PATEL, Meena V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  RYTHER, Keith B. ,  TIETJE, Karin Rosemarie

IPC: C07D277/46 ,  C07D277/48 ,  C07D277/82 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D493/08 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61P29/00

CPC classification number: C07D277/46 ,  A61K31/429 ,  C07D277/48 ,  C07D277/82 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D493/08 ,  C07D513/04

Abstract: The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L2, are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，前药，前药的盐或其组合，其中R 1，R 2，R 3，R 4和L 2在说明书中定义，包含此类化合物的组合物， 以及使用这样的化合物和组合物治疗病症和障碍的方法。

公开(公告)号：EP2176219A1

公开(公告)日：2010-04-21

申请号：EP08796115.7

申请日：2008-07-09

Applicant: Abbott Laboratories

Inventor： CARROLL, William A. ,  NELSON, Derek W. ,  PEREZ-MEDRANO, Arturo

IPC: C07D205/04 ,  C07D333/70 ,  C07D401/06 ,  C07D495/04 ,  A61K31/381 ,  A61P29/00

CPC classification number: C07D333/70 ,  C07D205/04 ,  C07D401/06 ,  C07D495/04

Abstract: The present application relates to cannabinoid receptor ligands containing compounds of formula (I) wherein A, R1, R2, and R3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：EP1278746A2

公开(公告)日：2003-01-29

申请号：EP01934990.1

申请日：2001-05-02

Applicant: Abbott Laboratories

Inventor： CARROLL, William A. ,  AGRIOS, Konstantinos A. ,  BASHA, Fatima Z. ,  CHEN, Yiyuan ,  KORT, Michael E. ,  KYM, Philip R. ,  TANG, Rui ,  TURNER, Sean C. ,  YI, Lin

IPC: C07D471/14 ,  A61K31/4353 ,  A61P15/00 ,  A61P21/00 ,  C07D471/04 ,  C07D491/048 ,  C07D495/14 ,  C07D491/056

CPC classification number: C07D471/04 ,  C07C45/00 ,  C07C45/298 ,  C07C45/30 ,  C07C45/63 ,  C07C205/44 ,  C07D471/14 ,  C07D491/04 ,  C07D491/14 ,  C07D495/14 ,  C07C47/55

Abstract: Compounds having the formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：EP2219629A1

公开(公告)日：2010-08-25

申请号：EP08837396.4

申请日：2008-10-08

Applicant: Abbott Laboratories

Inventor： CARROLL, William A. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  DART, Michael J. ,  NELSON, Derek W. ,  LI, Tongmei ,  LIU, Bo ,  KOLASA, Teodozyj ,  FROST, Jennifer ,  WANG, Xueqing ,  LATSHAW, Steven, P.

IPC: A61K31/015 ,  A61P43/00

CPC classification number: C07D405/06 ,  C07D405/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14

Abstract: The present invention relates compounds of formula (I), as defined in the specification, pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions.

Abstract translation: 本发明涉及如说明书中所定义的式（I）化合物，包含此类化合物的药物组合物，以及使用此类化合物和药物组合物治疗病症和障碍的方法。

公开(公告)号：EP2038266A2

公开(公告)日：2009-03-25

申请号：EP07797862.5

申请日：2007-05-30

Applicant: ABBOTT LABORATORIES

Inventor： DART, Michael J. ,  CARROLL, William A. ,  FLORJANCIC, Alan S. ,  FROST, Jennifer M. ,  GALLAGHER, Megan E. ,  LI, Tongmei ,  NELSON, Derek W. ,  PATEL, Meena V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  RYTHER, Keith B. ,  TIETJE, Karin Rosemarie ,  KOLASA, Teodozyj

IPC: C07D277/46 ,  C07D277/48 ,  C07D277/60 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/429 ,  A61P29/00

CPC classification number: C07D277/82 ,  C07D277/46 ,  C07D277/48 ,  C07D277/60 ,  C07D417/06 ,  C07D417/12 ,  C07D477/14 ,  C07D513/04

Abstract: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.