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11.发明申请1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS 审中-公开在2位置上被苯基取代的苯并咪唑-4-羧酰胺是一种残留的PARP抑制剂
公开(公告)号：WO2007041357A1
公开(公告)日：2007-04-12
申请号：PCT/US2006/038169
申请日：2006-09-28
Applicant: ABBOTT LABORATORIES , PENNING, Thomas, D. , THOMAS, Sheela, A. , ZHU, Gui-Dong , GANDHI, Virajkumar, B. , GONG, Jianchun , GIRANDA, Vincent, L.
Inventor： PENNING, Thomas, D. , THOMAS, Sheela, A. , ZHU, Gui-Dong , GANDHI, Virajkumar, B. , GONG, Jianchun , GIRANDA, Vincent, L.
IPC: C07D401/10 , C07D403/10 , A61K31/454 , A61K31/4178 , A61P29/00 , A61P31/00 , A61P35/00
CPC classification number: C07D401/14 , C07D235/18 , C07D401/10 , C07D403/10
Abstract: Compounds having formula (I), inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds having formula (I), methods of treatment comprising compounds having formula (I), and methods of inhibiting the PARP enzyme comprising compounds having formula (I).
Abstract translation: 具有式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含具有式（I）的化合物，包括具有式（I）的化合物的处理方法的药物组合物，以及包含具有式（I）的化合物的PARP酶的抑制方法。
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12.发明申请
公开(公告)号：WO2003051366A3
公开(公告)日：2003-06-26
申请号：PCT/US2002/039915
申请日：2002-12-12
Applicant: ABBOTT LABORATORIES
Inventor： LI, Qun , WOODS, Keith, W. , ZHU, Gui-Dong , FISCHER, John, P. , GONG, Jianchun , LI, Tongmei , GANDHI, Viraj , THOMAS, Sheela, A. , PACKARD, Garrick , SONG, Xiaohong , ABRAMS, Jason, N. , DIEBOLD, Robert , DINGES, Jurgen , HUTCHINS, Charles , STOLL, Vincent, S. , ROSENBERG, Saul, H. , GIRANDA, Vincent, L.
IPC: A61K31/4439
Abstract: Compounds having the formula (I), are useful for inhibiting protein kinases and for the treatment of cancer. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.
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公开(公告)号：EP2183248A2
公开(公告)日：2010-05-12
申请号：EP08781874.6
申请日：2008-07-16
Applicant: Abbott Laboratories
Inventor： GANDHI, Virajkumar B , GIRANDA, Vincent L , GONG, Jianchun , PENNING, Thomas D , ZHU, Gui-Dong
IPC: C07D417/14 , A61K31/427 , A61P35/00
CPC classification number: C07D417/14 , C07D405/14 , C07D409/14 , C07D413/14
Abstract: Compounds which inhibit the activity of poly(ADP-ribose)polymerase (PARP), compositions containing the compounds and methods of treating diseases using them are disclosed.
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14.发明公开SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS 有权取代的1H-苯并咪唑-4-甲酰胺是有效的PARP抑制剂
公开(公告)号：EP1966157A2
公开(公告)日：2008-09-10
申请号：EP06837694.6
申请日：2006-11-15
Applicant: ABBOTT LABORATORIES
Inventor： PENNING, Thomas D. , THOMAS, Sheela A. , ZHU, Gui-Dong , GONG, Jianchun , GIRANDA, Vincent L. , GANDHI, Viraj B.
IPC: C07D235/18
CPC classification number: C07D235/18 , C07D409/04 , C07D413/04 , C07D417/04
Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
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15.发明授权1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH A QUATERNARY CARBON AT THE 2-POSITION ARE POTENT PARP INHIBITORS 有权与在第二位置处的季碳取代的1H-苯并咪唑-4-甲酰胺是强PARP抑制剂
公开(公告)号：EP1869011B1
公开(公告)日：2012-08-01
申请号：EP06749882.4
申请日：2006-04-11
Applicant: Abbott Laboratories
Inventor： ZHU, Guidong , GONG, Jianchun , GANDHI, Virajkumar, B. , PENNING, Thomas, D. , GIRANDA, Vincent
IPC: C07D401/04 , C07D403/04 , A61K31/4184 , A61K31/454
CPC classification number: C07D403/04 , C07D207/16 , C07D401/04 , C07D401/14 , C07D405/14
Abstract: Compounds of Formula (I) (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
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Patent Agency Ranking16.发明授权SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS 有权取代的1H-苯并咪唑-4-甲酰胺是有效的PARP抑制剂
公开(公告)号：EP1966157B1
公开(公告)日：2010-03-24
申请号：EP06837694.6
申请日：2006-11-15
Applicant: ABBOTT LABORATORIES
Inventor： PENNING, Thomas D. , THOMAS, Sheela A. , ZHU, Gui-Dong , GONG, Jianchun , GIRANDA, Vincent L. , GANDHI, Viraj B.
IPC: C07D235/18
CPC classification number: C07D235/18 , C07D409/04 , C07D413/04 , C07D417/04
Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
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公开(公告)号：EP1989204A1
公开(公告)日：2008-11-12
申请号：EP07757073.7
申请日：2007-02-15
Applicant: ABBOTT LABORATORIES
Inventor： PENNING, Thomas, D. , ZHU, Gui-dong , GANDHI, Virajkumar, B. , GONG, Jianchun , GIRANDA, Vincent, L.
IPC: C07D471/04 , A61K31/438 , A61P35/00 , C07D491/04 , C07D495/04
CPC classification number: C07D471/04 , A61K31/47 , A61K31/497 , A61K31/53 , A61K31/535 , C07D491/04 , C07D495/04
Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
Abstract translation: 式（I）化合物抑制PARP酶并可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物的药物组合物，包含式（I）化合物的治疗方法和抑制包含式（I）化合物的PARP酶的方法。
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18.发明公开
公开(公告)号：EP1001930A2
公开(公告)日：2000-05-24
申请号：EP98936014.4
申请日：1998-07-27
Applicant: Abbott Laboratories
Inventor： CURTIN, Michael, L. , DAVIDSEN, Steven, K. , DELLARIA, Joseph, F., Jr. , FLORJANCIC, Alan, S. , GIESLER, Jamie , GONG, Jianchun , GUO, Yan , HEYMAN, H., Robin , HOLMS, James, H. , MICHAELIDES, Michael, R. , STEINMAN, Douglas, H. , WADA, Carol, K. , XU, Lianhong
IPC: C07C259/00
CPC classification number: C07D207/404 , C07C311/05 , C07C311/18 , C07C317/28 , C07C323/47 , C07C323/62 , C07D207/408 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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19.发明授权SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS 有权取代的1H-苯并咪唑-4-甲酰胺作为有效的PARP抑制剂
公开(公告)号：EP2012780B1
公开(公告)日：2012-04-11
申请号：EP07761722.3
申请日：2007-05-02
Applicant: ABBOTT LABORATORIES
Inventor： GIRANDA, Vincent L. , PENNING, Thomas D. , GANDHI, Virajkumar B. , THOMAS, Sheela A. , ZHU, Gui-dong , GONG, Jianchun
IPC: C07D403/10 , C07D235/18 , C07D409/04 , A61P29/00 , A61P37/00 , A61K31/4184
CPC classification number: C07D403/10 , C07D235/18 , C07D409/04
Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
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公开(公告)号：EP2120579A1
公开(公告)日：2009-11-25
申请号：EP07869628.3
申请日：2007-12-20
Applicant: ABBOTT LABORATORIES
Inventor： GANDHI, Viraj B. , GIRANDA, Vincent L. , GONG, Jianchun , PENNING, Thomas D. , ZHU, Gui-dong
IPC: A01N43/58 , A61K31/50 , A61K31/495
CPC classification number: C07D403/10 , C07D237/32 , C07D403/12 , C07D403/14 , Y02P20/582
Abstract: Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.
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