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    Automatic analyser
    11.
    发明公开
    Automatic analyser 失效
    自动分析

    公开(公告)号：EP0831329A2

    公开(公告)日：1998-03-25

    申请号：EP97114411.8

    申请日：1997-08-20

    Applicant: Abbott Laboratories

    Inventor： Arnquist, David C. ,  Barnes, Grady, III ,  Button, Richard D. ,  Dunn, Chadwick M. ,  East, Richard C., Jr. ,  Fritchie, Patrick P. ,  Galitz, Charles M. ,  Grandone, Cass J. ,  Gardner, Gregory E. ,  Gray, Robert C. ,  Holen, James T. ,  Luoma, Robert P., II ,  McCory, Jimmy D. ,  Mitchell, James E. ,  Murray, Adrian John ,  Murray, David W. ,  Ramsey, Jack F. ,  Sleszynski, Neal T. ,  Toth, Julius J.

    IPC: G01N35/04

    CPC classification number: B01L3/508 ,  B01L2300/0851 ,  G01N21/76 ,  G01N35/0092 ,  G01N35/025 ,  G01N35/04 ,  G01N2035/00534 ,  G01N2035/00752 ,  G01N2035/0465 ,  G01N2035/0467

    Abstract: The structure embodiments disclosed relate to determination of an item of interest in a sample. One embodiment relates to a structure which comprises a process path (10). The process path (10) comprises a process lane (28) including a process step performance lane (62) where a process step is performed, and a process step avoidance lane (64) where the process step is avoided. A first prime mover (24) is operatively connected with the process path (10) for moving a container (15) holding the sample along the process path (10). A first pipetting system (198) is operatively associated with the process path (10) for introducing the sample to the container (15). A second pipetting system (132, 134) is operatively associated with the process path (10) for introducing a reagent to the container (15). A device (86) is operatively connected with the process path (10) and is selectively engagable with the container (15) for mixing the sample and the reagent in the container (15). A second prime mover (44) is operatively connected with the process path (10) for selectively positioning the container (15) in a selected one of the process step performance lane (62) and the process step avoidance lane (64). A reader (138) is operatively connected with the process path (10) for determining the item of interest in the sample based upon a reaction between the sample and the reagent.
    The method embodiments disclosed relate to determination of an item of interest in a sample. In one method, a process path (10) comprising a process lane (28) including a process step performance lane (62) where a process step is performed, and a process step avoidance lane (64) where the process step is avoided is provided. A container (15) holding the sample is moved along the process path (10). The sample is introduced to the container (15). A reagent is introduced to the container (15). The sample and the reagent are mixed in the container (15). The container (15) is selectively positioned in a selected one of the process step performance lane (62) and the process step avoidance lane (64). The item of interest in the sample is determined based upon a reaction between the sample and the reagent.

    Abstract translation: 所公开的结构实施例涉及样品中感兴趣物品的确定。 一个实施例涉及包括处理路径（10）的结构。 过程路径（10）包括包括执行处理步骤的处理步骤执行通道（62）和避免处理步骤的处理步骤回避通道（64）的处理通道（28）。 第一原动机（24）与处理路径（10）可操作地连接，用于沿着处理路径（10）移动保持样品的容器（15）。 第一移液系统（198）与用于将样品引入容器（15）的处理路径（10）可操作地相关联。 第二移液系统（132,134）与用于将试剂引入容器（15）的过程路径（10）可操作地相关联。 装置（86）与处理路径（10）可操作地连接，并且可选择地与容器（15）接合，用于将样品和试剂混合在容器（15）中。 第二原动机（44）与处理路径（10）可操作地连接，用于将容器（15）选择性地定位在所选择的一个工艺步骤性能车道（62）和工艺步骤回避车道（64）中。 读取器（138）与处理路径（10）可操作地连接，用于基于样品和试剂之间的反应来确定样品中的感兴趣物品。 所公开的方法实施例涉及确定样本中的感兴趣项目。 在一种方法中，提供包括处理通道（28）的处理路径（10），其包括执行处理步骤的处理步骤性能通道（62）和避免处理步骤的处理步骤回避通道（64） 。 保持样品的容器（15）沿着处理路径（10）移动。 将样品引入容器（15）。 将试剂引入容器（15）。 样品和试剂在容器（15）中混合。 容器（15）被选择性地定位在处理步骤执行车道（62）和处理步骤回避车道（64）中的所选择的一个中。 基于样品和试剂之间的反应确定样品中的感兴趣物质。

    Centrifuge
    13.
    发明公开
    Centrifuge 失效
    离心机

    公开(公告)号：EP0160901A3

    公开(公告)日：1986-03-05

    申请号：EP85105108

    申请日：1985-04-26

    Applicant: ABBOTT LABORATORIES

    Inventor： Holen, James T. ,  Burke, Charles R.

    IPC: B04B05/04 ,  B04B05/02 ,  B01D21/26

    CPC classification number: B04B5/0407 ,  B01D21/262 ,  B01D2221/10 ,  B04B5/02

    Abstract: Method and apparatus for generating centrifugal forces, including a plate rotatable about an axis, and at least one holding means mounted on the plate for rotation therewith, the holding means being adapted to receive an article to be subjected to centrifugal force and being rotatable relative to the plate member to permit the direction of centrifugal force acting on the article to be changed.

    Centrifuge
    14.
    发明公开
    Centrifuge 失效
    Zentrifuge。

    公开(公告)号：EP0160901A2

    公开(公告)日：1985-11-13

    申请号：EP85105108.6

    申请日：1985-04-26

    Applicant: ABBOTT LABORATORIES

    Inventor： Holen, James T. ,  Burke, Charles R.

    IPC: B04B5/04 ,  B04B5/02 ,  B01D21/26

    CPC classification number: B04B5/0407 ,  B01D21/262 ,  B01D2221/10 ,  B04B5/02

    Abstract: Method and apparatus for generating centrifugal forces, including a plate rotatable about an axis, and at least one holding means mounted on the plate for rotation therewith, the holding means being adapted to receive an article to be subjected to centrifugal force and being rotatable relative to the plate member to permit the direction of centrifugal force acting on the article to be changed.

    Abstract translation: 用于产生离心力的方法和装置，包括可围绕轴线旋转的板，以及安装在板上用于与其一起旋转的至少一个保持装置，该保持装置适于容纳待经受离心力并可相对于 所述板构件允许作用在所述制品上的离心力的方向改变。

    Processor card for centrifuge
    15.
    发明公开
    Processor card for centrifuge 失效
    Behandlungskartefüreine Zentrifuge。

    公开(公告)号：EP0160282A2

    公开(公告)日：1985-11-06

    申请号：EP85105106.0

    申请日：1985-04-26

    Applicant: ABBOTT LABORATORIES

    Inventor： Holen, James T.

    IPC: G01N21/07 ,  B04B5/04

    CPC classification number: G01N21/07 ,  B04B5/0407

    Abstract: A sample processor card for use with a centrifuge in which the direction of centrifugal force can be altered at will, wherein the card includes a supply of chemical reagent and inlet means for supplying a chemical sample to the card. The sample is advanced under centrifugal force through capillary means to sample measuring means, and the measured sample is then mixed with reagent to permit a chemical test to be carried out on the reagent, all under centrifugal force.

    Abstract translation: 一种与离心机一起使用的样品处理器卡，其中可以随意改变离心力的方向，其中所述卡片包括供应化学试剂和用于向所述卡提供化学样品的入口装置。 样品在离心力下通过毛细管装置进样到样品测量装置上，然后将所测量的样品与试剂混合，以允许在试剂上进行化学试验，全部在离心力下进行。

    Biological sample analyzer
    20.
    发明公开
    Biological sample analyzer 失效
    Vorrichtung zur分析生物学家Proben。

    公开(公告)号：EP0353591A2

    公开(公告)日：1990-02-07

    申请号：EP89113616.0

    申请日：1989-07-24

    Applicant: ABBOTT LABORATORIES

    Inventor： Defreese, James Douglas ,  Huang, Tung-Ming ,  Holen, James T. ,  Gray, Robert Carlton ,  Bailey, Mark Wallace ,  Donohue, Joseph Patrick ,  Putterman, Caryn Glickson

    IPC: G01N35/02 ,  G01N21/47 ,  G01N33/53

    CPC classification number: G01N33/5302 ,  G01J2001/161 ,  G01J2001/1636 ,  G01N21/253 ,  G01N35/00029 ,  G01N2021/0162 ,  G01N2021/478 ,  G01N2035/00099 ,  G01N2035/00752 ,  G01N2035/1025 ,  G01N2201/0415 ,  G01N2201/069 ,  G01N2201/12761

    Abstract: A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immuno assays for himan IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples. A carou­sel is provided to position and hold a plurality of reaction cartridges. Each reaction cartridge includes a plurality of isolated test sites formed in a two dimensional array in a solid phase binding layer con­tained within a reaction well which is adapted to con­tain a biological sample to be assayed. The carousel and cartridges contain structures which cooperate to precisely position the cartridges in each of three separate dimensions so that each cartridge is posi­tioned uniformly. An optical reader operating on a principle of diffuse reflectance is provided to read the results of the assays from each test site of each cartridge. Also provided is a subsystem which provides predetermined lot-specific assay calibration data which is useful for normalizing the results of various assays with respect to predetermined common standard values.

    Abstract translation: 提供半自动化生物样品分析仪和子系统，以同时对多个生物样品中的每一个中预先选择的过敏原的一组特异性的himan IgE类抗体进行多次酶免疫测定。 提供转盘以定位和保持多个反应盒。 每个反应盒包括在包含在反应井内的固相结合层中的二维阵列中形成的多个分离的测试位点，其适于含有要测定的生物样品。 圆盘传送带和墨盒包含结构，其配合以将墨盒精确地定位在三个分开的尺寸中的每一个中，使得每个墨盒均匀地定位。 提供以漫反射原理工作的光学阅读器，以从每个盒的每个测试位置读取测定结果。 还提供了一种子系统，其提供预定的特异性测定校准数据，其可用于相对于预定的共同标准值标准化各种测定的结果。

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