公开(公告)号：EP2265610B1

公开(公告)日：2012-12-12

申请号：EP09718306.5

申请日：2009-02-27

Applicant: Array Biopharma, Inc. ,  Genentech, Inc.

Inventor： AHRENDT, Kateri A. ,  BUCKMELTER, Alexandre J. ,  DE MEESE, Jason ,  GRINA, Jonas ,  HANSEN, Joshua D. ,  LAIRD, Ellen R. ,  LUNGHOFER, Paul ,  MORENO, David ,  NEWHOUSE, Brad ,  REN, Li ,  SEO, Jeongbeob ,  TIAN, Hongqi ,  WENGLOWSKY, Steven Mark ,  FENG, Bainian ,  GUNZNER, Janet ,  MALESKY, Kim ,  MATHIEU, Simon ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  YOUNG, Wendy B.

IPC: C07D471/04 ,  C07C311/08 ,  A61K31/437 ,  A61P13/12 ,  A61P35/00

CPC classification number: C07D471/04 ,  C07C311/08

公开(公告)号：EP2493865A2

公开(公告)日：2012-09-05

申请号：EP10805862.9

申请日：2010-08-27

Applicant: Array Biopharma, Inc. ,  Genentech, Inc.

Inventor： ALIAGAS, Ignacio ,  GRADL, Stefan ,  GUNZNER, Janet ,  LEE, Wendy ,  MATHIEU, Simon ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  ZHAO, Guiling ,  BUCKMELTER, Alexandre J. ,  GRINA, Jonas ,  HANSEN, Joshua D. ,  LAIRD, Ellen ,  MORENO, David ,  REN, Li ,  WENGLOWSKY, Steven Mark

IPC: C07D239/94 ,  C07D403/12 ,  C07D405/12 ,  C07D471/04 ,  A61K31/517 ,  A61K31/519 ,  A61P35/00

CPC classification number: C07D239/94 ,  C07D403/12 ,  C07D405/12 ,  C07D471/04

Abstract: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof,
for in vitro, in situ , and
in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 式I化合物可用于抑制Raf激酶。 公开了使用式I化合物及其立体异构体，互变异构体，前药和药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞中的这些病症或相关病理学病症的方法。

公开(公告)号：EP1934228A2

公开(公告)日：2008-06-25

申请号：EP06813989.8

申请日：2006-08-31

Applicant: Array Biopharma, Inc.

Inventor： MIKNIS, Greg ,  LYSSIKATOS, Joseph P. ,  LAIRD, Ellen ,  TARLTON, Eugene ,  BUCKMELTER, Alexandre J. ,  REN, Li ,  RAST, Bryson ,  SCHLACTER, Stephen T. ,  WENGLOWSKY, Steven Mark

IPC: C07D495/04 ,  C07D491/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00

CPC classification number: C07D491/04 ,  C07D495/04

Abstract: Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.