公开(公告)号：WO2007027855A2

公开(公告)日：2007-03-08

申请号：PCT/US2006/033976

申请日：2006-08-31

Applicant: ARRAY BIOPHARMA INC. ,  MIKNIS, Greg ,  LYSSIKATOS, Joseph P. ,  LAIRD, Ellen ,  TARLTON, Eugene ,  BUCKMELTER, Alexandre J. ,  REN, Li ,  RAST, Bryson ,  SCHLACTER, Stephen T. ,  WENGLOWSKY, Steven Mark

Inventor： MIKNIS, Greg ,  LYSSIKATOS, Joseph P. ,  LAIRD, Ellen ,  TARLTON, Eugene ,  BUCKMELTER, Alexandre J. ,  REN, Li ,  RAST, Bryson ,  SCHLACTER, Stephen T. ,  WENGLOWSKY, Steven Mark

CPC classification number: C07D491/04 ,  C07D495/04

Abstract: Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro , in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 式I的化合物可用于抑制Raf激酶和用于治疗由此介导的病症。 使用式I化合物及其立体异构体，几何异构体，互变异构体，溶剂合物及其药学上可接受的盐的方法用于在哺乳动物细胞或相关病理状况下的体外，原位和体内诊断，预防或治疗这些疾病。 披露。

公开(公告)号：EP1934228A2

公开(公告)日：2008-06-25

申请号：EP06813989.8

申请日：2006-08-31

Applicant: Array Biopharma, Inc.

Inventor： MIKNIS, Greg ,  LYSSIKATOS, Joseph P. ,  LAIRD, Ellen ,  TARLTON, Eugene ,  BUCKMELTER, Alexandre J. ,  REN, Li ,  RAST, Bryson ,  SCHLACTER, Stephen T. ,  WENGLOWSKY, Steven Mark

IPC: C07D495/04 ,  C07D491/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00

CPC classification number: C07D491/04 ,  C07D495/04

Abstract: Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.