公开(公告)号：WO2020047184A1

公开(公告)日：2020-03-05

申请号：PCT/US2019/048701

申请日：2019-08-29

Applicant: ARRAY BIOPHARMA INC.

Inventor： HINKLIN, Ronald Jay ,  ALLEN, Shelley ,  BARBOUR, Patrick ,  COOK, Adam ,  DAHLKE, Joshua ,  GAUDINO, John ,  LAIRD, Ellen ,  MCNULTY, Oren T. ,  ZHAO, Qian

IPC: A61P35/00 ,  C07D471/04 ,  A61K31/437

Abstract: Provided herein are compounds of the Formula (I): and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 9 , X 1 and G are as defined herein, which are inhibitors of one or more TAM kinases and/or c-Met kinase, and are useful in the treatment and prevention of diseases which can be treated with a TAM kinase inhibitor and/or a c-Met kinase inhibitor.

公开(公告)号：WO2012118492A1

公开(公告)日：2012-09-07

申请号：PCT/US2011/026700

申请日：2011-03-01

Applicant: ARRAY BIOPHARMA INC. ,  GENENTECH, INC. ,  GRINA, Jonas ,  HANSEN, Joshua D. ,  LAIRD, Ellen ,  MATHIEU, Simon ,  MORENO, David ,  REN, Li ,  RUDOLPH, Joachim ,  WENGLOWSKY, Steven Mark

Inventor： GRINA, Jonas ,  HANSEN, Joshua D. ,  LAIRD, Ellen ,  MATHIEU, Simon ,  MORENO, David ,  REN, Li ,  RUDOLPH, Joachim ,  WENGLOWSKY, Steven Mark

IPC: C07D239/74 ,  C07D239/88 ,  C07D239/94 ,  C07D241/44 ,  C07D403/04 ,  C07D405/14 ,  A61K31/498 ,  A61K31/517 ,  A61P35/00

CPC classification number: C07D239/88 ,  C07D239/74 ,  C07D239/94 ,  C07D241/44 ,  C07D403/04 ,  C07D405/14

Abstract: Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula (I), stereoisomers, tautomers and pharmaceutically acceptable salts thereof, for i n vitro , in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 式（I）的化合物可用于抑制Raf激酶。 公开了使用式（I）化合物，立体异构体，互变异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

公开(公告)号：WO2011025938A2

公开(公告)日：2011-03-03

申请号：PCT/US2010/046952

申请日：2010-08-27

Applicant: ARRAY BIOPHARMA INC. ,  GENENTECH, INC. ,  ALIAGAS, Ignacio ,  GRADL, Stefan ,  GUNZNER, Janet ,  LEE, Wendy ,  MATHIEU, Simon ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  ZHAO, Guiling ,  BUCKMELTER, Alexandre J. ,  GRINA, Jonas ,  HANSEN, Joshua D. ,  LAIRD, Ellen ,  MORENO, David ,  REN, Li ,  WENGLOWSKY, Steven Mark

Inventor： ALIAGAS, Ignacio ,  GRADL, Stefan ,  GUNZNER, Janet ,  LEE, Wendy ,  MATHIEU, Simon ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  ZHAO, Guiling ,  BUCKMELTER, Alexandre J. ,  GRINA, Jonas ,  HANSEN, Joshua D. ,  LAIRD, Ellen ,  MORENO, David ,  REN, Li ,  WENGLOWSKY, Steven Mark

IPC: A61K31/5377 ,  C07D487/02

CPC classification number: C07D239/94 ,  C07D403/12 ,  C07D405/12 ,  C07D471/04

Abstract: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 式I化合物可用于抑制Raf激酶。 使用式I化合物及其立体异构体，互变异构体，前药和药学上可接受的盐用于体外，原位和体内诊断，预防或治疗的方法 披露了哺乳动物细胞中的病症或相关的病理学病症。

公开(公告)号：WO2006125101A3

公开(公告)日：2006-11-23

申请号：PCT/US2006/019280

申请日：2006-05-18

Applicant: ARRAY BIOPHARMA INC. ,  LAIRD, Ellen ,  TOPALOV, George ,  LYSSIKATOS, Joseph, P. ,  WELCH, Mike ,  GRINA, Jonas ,  HANSEN, Josh ,  NEWHOUSE, Brad

Inventor： LAIRD, Ellen ,  TOPALOV, George ,  LYSSIKATOS, Joseph, P. ,  WELCH, Mike ,  GRINA, Jonas ,  HANSEN, Josh ,  NEWHOUSE, Brad

IPC: C07D487/04 ,  A61K31/4985 ,  A61P35/00

Abstract: Compounds of Formula (I) are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula (I), and stereoisomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：WO2006044825A2

公开(公告)日：2006-04-27

申请号：PCT/US2005/037305

申请日：2005-10-18

Applicant: ARRAY BIOPHARMA INC. ,  HANS, Jeremy ,  WALLACE, Eli, M. ,  WALLACE, Eli, M. ,  ZHAO, Qian ,  LYSSIKATOS, Joseph, P. ,  AICHER, Tom ,  LAIRD, Ellen ,  ROBINSON, John ,  ALLEN, Shelley

Inventor： HANS, Jeremy ,  WALLACE, Eli, M. ,  WALLACE, Eli, M. ,  ZHAO, Qian ,  LYSSIKATOS, Joseph, P. ,  AICHER, Tom ,  LAIRD, Ellen ,  ROBINSON, John ,  ALLEN, Shelley

IPC: A61K38/04 ,  A61K31/675 ,  A61K31/496 ,  A61K31/4439 ,  A61K31/433 ,  A61K31/4245 ,  C07D417/04 ,  C07D413/04

CPC classification number: C07D285/12 ,  C07D271/107 ,  C07D401/12 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07F9/201 ,  C07F9/65392

Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.

公开(公告)号：EP2558468A1

公开(公告)日：2013-02-20

申请号：EP11715818.8

申请日：2011-04-11

Applicant: Array Biopharma, Inc.

Inventor： BOYS, Mark Laurence ,  BURGESS, Laurence, E. ,  GRONEBERG, Robert, D. ,  HARVEY, Darren, M. ,  HUANG, Lily ,  KERCHER, Timothy ,  KRASER, Christopher, F. ,  LAIRD, Ellen ,  TARLTON, Eugene ,  ZHAO, Qian

IPC: C07D487/04 ,  A61P29/00 ,  A61P37/00 ,  A61K31/519

CPC classification number: C07D487/04 ,  C07D498/04

Abstract: Compounds of Formula I: (Formula should be inserted here) and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , R
7 , X
1 and X
2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.

公开(公告)号：EP1809280B1

公开(公告)日：2011-09-07

申请号：EP05819172.7

申请日：2005-10-18

Applicant: Array Biopharma, Inc.

Inventor： HANS, Jeremy ,  WALLACE, Eli M. ,  ZHAO, Qian ,  LYSSIKATOS, Joseph P. ,  AICHER, Tom ,  LAIRD, Ellen ,  ROBINSON, John ,  ALLEN, Shelley

IPC: A61K31/4245 ,  C07D417/00 ,  C07D413/00

CPC classification number: C07D285/12 ,  C07D271/107 ,  C07D401/12 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07F9/201 ,  C07F9/65392

Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.

公开(公告)号：EP2766368A1

公开(公告)日：2014-08-20

申请号：EP12775905.8

申请日：2012-10-09

Applicant: Array Biopharma Inc.

Inventor： BOYS, Mark Laurence ,  BURGESS, Laurence E. ,  EARY, C. Todd ,  GRONEBERG, Robert ,  HACHE, Bruno P. ,  HARVEY, Darren ,  HICKEN, Erik James ,  KRASER, Christopher F. ,  LAIRD, Ellen ,  MORENO, David A. ,  MUNSON, Mark C. ,  REN, Li ,  ROBINSON, John E. ,  SCHLACHTER, Stephen T.

IPC: C07D487/04 ,  A61K31/519 ,  A61P29/00 ,  A61P37/00

CPC classification number: C07D487/04

Abstract: Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , X
1 and X
2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.

Abstract translation: 其中R 1，R 2，R 3，R 4，R 5，R 6，X 1和X 2具有说明书中给出的含义的式I化合物及其立体异构体和药学上可接受的盐和溶剂合物是 一种或多种JAK激酶，并且可用于治疗自身免疫性疾病，炎性疾病，移植器官，组织和细胞的排斥，以及血液病和恶性肿瘤及其并发症。

公开(公告)号：EP2470538A1

公开(公告)日：2012-07-04

申请号：EP10749740.6

申请日：2010-08-27

Applicant: Array Biopharma, Inc. ,  Genentech, Inc.

Inventor： ALIAGAS, Ignacio ,  GRADL, Stefan ,  GUNZNER, Janet ,  MATHIEU, Simon ,  PULK, Rebecca ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  GRINA, Jonas ,  HANSEN, Joshua D. ,  LAIRD, Ellen ,  MORENO, David ,  REN, Li ,  WENGLOWSKY, Steven Mark

IPC: C07D487/04 ,  C07D495/04 ,  C07D513/04 ,  A61K31/38 ,  A61P35/00

CPC classification number: C07D487/04 ,  C07D495/04 ,  C07D513/04

Abstract: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for
in vitro ,
in situ , and
in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：EP1879886A1

公开(公告)日：2008-01-23

申请号：EP06758821.0

申请日：2006-05-01

Applicant: Array Biopharma, Inc.

Inventor： HANS, Jeremy ,  WALLACE, Eli M. ,  ZHAO, Qian ,  ALLEN, Shelley ,  LAIRD, Ellen ,  LYSSIKATOS, Joseph P. ,  ROBINSON, John E. ,  CORRETTE, Christopher P. ,  DELISLE, Robert Kirk ,  VOEGTLI, Walter Charles

IPC: C07D417/04

CPC classification number: C07D513/04 ,  C07D285/12 ,  C07D417/04 ,  C07D417/14 ,  C07D419/04 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D497/04 ,  C07F9/65395

Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.