公开(公告)号：ZA8803428B

公开(公告)日：1990-01-31

申请号：ZA8803428

申请日：1988-05-16

Applicant: BASF AG

Inventor： DOERPER THOMAS ,  THOMAS DOERPER ,  MOELLER ACHIM ,  ACHIM MOELLER ,  HILLEN HEINZ ,  HEINZ HILLEN ,  KEILHAUER GERHARD ,  GERHARD KEILHAUER ,  EMLING FRANZ ,  FRANZ EMLING ,  DAUM LOTHAR ,  LOTHAR DAUM

IPC: C12N15/09 ,  A61K38/00 ,  A61P35/00 ,  C07K1/20 ,  C07K14/00 ,  C07K14/52 ,  C07K14/525 ,  C07K14/78 ,  C07K19/00 ,  C12P21/02 ,  C12R1/19 ,  C07K ,  C07H ,  C12P

CPC classification number: C07K14/78 ,  A61K38/00 ,  C07K14/525 ,  C07K2319/00 ,  C07K2319/33 ,  C07K2319/75 ,  Y10S930/144

公开(公告)号：FI882283A

公开(公告)日：1988-11-17

申请号：FI882283

申请日：1988-05-16

Applicant: BASF AG

Inventor： DOERPER THOMAS ,  MOELLER ACHIM ,  HILLEN HEINZ ,  KEILHAUER GERHARD ,  EMLING FRANZ ,  DAUM LOTHAR

IPC: C12N15/09 ,  A61K38/00 ,  A61P35/00 ,  C07K1/20 ,  C07K14/00 ,  C07K14/52 ,  C07K14/525 ,  C07K14/78 ,  C07K19/00 ,  C12P21/02 ,  C12R1/19 ,  C12N

Abstract: Tumor necrosis factor (TNF) produced from the TNF molecule by modification at the amino terminus are prepared as described and are suitable for controlling diseases.

公开(公告)号：DK263588D0

公开(公告)日：1988-05-13

申请号：DK263588

申请日：1988-05-13

Applicant: BASF AG

Inventor： DOERPER THOMAS ,  MOELLER ACHIM ,  HILLEN HEINZ ,  KEILHAUER GERHARD ,  EMLING FRANZ ,  DAUM LOTHAR

IPC: C12N15/09 ,  A61K38/00 ,  A61P35/00 ,  C07K1/20 ,  C07K14/00 ,  C07K14/52 ,  C07K14/525 ,  C07K14/78 ,  C07K19/00 ,  C12P21/02 ,  C12R1/19 ,  C07K13/00 ,  C12N15/00

Abstract: Tumor necrosis factor (TNF) produced from the TNF molecule by modification at the amino terminus are prepared as described and are suitable for controlling diseases.

公开(公告)号：AU7452187A

公开(公告)日：1988-01-07

申请号：AU7452187

申请日：1987-06-19

Applicant: BASF AG

Inventor： SCHOLLMEIER KLAUS ,  MOELLER ACHIM ,  KOERWER WOLFGANG ,  DOERPER THOMAS ,  HILLEN HEINZ ,  DAUM LOTHAR ,  EMLING FRANZ ,  KEILHAUER GERHARD

IPC: C07K14/52 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/525 ,  C12N15/00 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  C07K13/00 ,  A61K37/02 ,  A61K37/42 ,  C07G17/00 ,  C07H21/04 ,  C12N1/20 ,  C12P19/34

公开(公告)号：ZA903475B

公开(公告)日：1992-01-29

申请号：ZA903475

申请日：1990-05-08

Applicant: BASF AG

Inventor： LEMAIRE HANS-GEORG ,  HANS-GEORG LEMAIRE ,  HILLEN HEINZ ,  HEINZ HILLEN ,  MOELLER ACHIM ,  ACHIM MOELLER ,  DAUM LOTHAR ,  LOTHAR DAUM ,  DOERPER THOMAS ,  THOMAS DOERPER ,  SUBKOWSKI THOMAS ,  THOMAS SUBKOWSKI

IPC: C07K20060101 ,  C07K

公开(公告)号：ZA893310B

公开(公告)日：1991-01-30

申请号：ZA893310

申请日：1989-05-05

Applicant: BASF AG

Inventor： DAUM LOTHAR ,  LOTHAR DAUM ,  KEILHAUER GERHARD ,  GERHARD KEILHAUER ,  LORENZ GISELA ,  GISELA LORENZ ,  ANKE TIMM ,  TIMM ANKE ,  AMMERMANN EBERHARD ,  EBERHARD AMMERMANN ,  WEBER WOLFGANG ,  WOLFGANG WEBER ,  STEGLICH WOLFGANG ,  WOLFGANG STEGLICH ,  STEFFAN BERT ,  BERT STEFFAN ,  SCHERER ANGELA ,  ANGELA SCHERER

IPC: C12P17/18 ,  A01N43/90 ,  A61K31/335 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  C07D493/10 ,  C12R1/645 ,  C07D ,  A61K ,  A01N ,  C12P

Abstract: Novel strobilurine derivatives which are suitable for the treatment of disorders and as fungicides are described.

公开(公告)号：CA2051124A1

公开(公告)日：1991-01-30

申请号：CA2051124

申请日：1990-07-20

Applicant: BASF AG

Inventor： DOERPER THOMAS ,  HILLEN HEINZ ,  EMLING FRANZ ,  DAUM LOTHAR ,  MOELLER ACHIM

IPC: A61K38/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/06 ,  C07K14/47 ,  C07K14/52 ,  C07K14/525 ,  C07K19/00 ,  C12N1/21 ,  C12N5/24 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  C12N15/62 ,  A61K38/19 ,  C12N15/28

Abstract: O.Z. 0050/40983 Proteins with TNF action Derivatives of tumor necrosis factor (TNF), which are derived from the TNF molecule by an alteration at the amino terminus, and the preparation thereof are described. The proteins are suitable for controlling diseases.

公开(公告)号：CA2047195A1

公开(公告)日：1990-08-26

申请号：CA2047195

申请日：1990-02-20

Applicant: BASF AG

Inventor： DAUM LOTHAR ,  KEILHAUER GERHARD ,  SAUTER HUBERT ,  BERTRAM GUNDA ,  ANKE TIMM ,  WEBER WOLFGANG ,  STEGLICH WOLFGANG

IPC: C07D319/14 ,  A61K31/335 ,  A61K31/357 ,  A61P31/04 ,  C07D407/12 ,  C07D493/10

Abstract: Novel .beta.-methoxyacrylates, the preparation and use thereof .beta.-methoxyacrylates of the formula in which R1, R2 and R3 have the meanings indicated in the description, and the preparation thereof are described. The compounds are suitable for controlling diseases.

公开(公告)号：AU600131B2

公开(公告)日：1990-08-02

申请号：AU1615188

申请日：1988-05-13

Applicant: BASF AG

Inventor： DOERPER THOMAS ,  MOELLER ACHIM ,  HILLEN HEINZ ,  KEILHAUER GERHARD ,  EMLING FRANZ ,  DAUM LOTHAR

IPC: C12N15/09 ,  A61K38/00 ,  A61P35/00 ,  C07K1/20 ,  C07K14/00 ,  C07K14/52 ,  C07K14/525 ,  C07K14/78 ,  C07K19/00 ,  C12P21/02 ,  C12R1/19 ,  C12N15/00 ,  C07K13/00 ,  A61K37/02 ,  A61K37/43 ,  C12N15/62

Abstract: Tumor necrosis factor (TNF) produced from the TNF molecule by modification at the amino terminus are prepared as described and are suitable for controlling diseases.

公开(公告)号：CA2005053A1

公开(公告)日：1990-06-23

申请号：CA2005053

申请日：1989-12-11

Applicant: BASF AG

Inventor： DAUM LOTHAR ,  DOERPER THOMAS ,  HILLEN HEINZ ,  MOELLER ACHIM ,  SCHOLLMEIER KLAUS ,  WALKER NIGEL ,  KEILHAUER GERHARD

IPC: A61K38/00 ,  C07K14/525 ,  C12N1/21 ,  C12N15/28 ,  C12N15/63

Abstract: - 25 - O.Z. 0050/40432 of the disclosure: TNF polypeptides which differ from natural TNF by the replacement and/or deletion of amino acids are described. The novel polypeptides are suitable for controlling diseases.