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公开(公告)号：HU202922B
公开(公告)日：1991-04-29
申请号：HU281387
申请日：1987-06-19
Applicant: BASF AG
Inventor： SCHOLLMEIER KLAUS , MOELLER ACHIM , KOERWER WOLFGANG , DOERPER THOMAS
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公开(公告)号：CA2051124A1
公开(公告)日：1991-01-30
申请号：CA2051124
申请日：1990-07-20
Applicant: BASF AG
Inventor： DOERPER THOMAS , HILLEN HEINZ , EMLING FRANZ , DAUM LOTHAR , MOELLER ACHIM
IPC: A61K38/00 , A61P29/00 , A61P31/04 , A61P37/06 , C07K14/47 , C07K14/52 , C07K14/525 , C07K19/00 , C12N1/21 , C12N5/24 , C12N15/09 , C12P21/02 , C12R1/19 , C12N15/62 , A61K38/19 , C12N15/28
Abstract: O.Z. 0050/40983 Proteins with TNF action Derivatives of tumor necrosis factor (TNF), which are derived from the TNF molecule by an alteration at the amino terminus, and the preparation thereof are described. The proteins are suitable for controlling diseases.
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公开(公告)号：AU600131B2
公开(公告)日：1990-08-02
申请号：AU1615188
申请日：1988-05-13
Applicant: BASF AG
Inventor： DOERPER THOMAS , MOELLER ACHIM , HILLEN HEINZ , KEILHAUER GERHARD , EMLING FRANZ , DAUM LOTHAR
IPC: C12N15/09 , A61K38/00 , A61P35/00 , C07K1/20 , C07K14/00 , C07K14/52 , C07K14/525 , C07K14/78 , C07K19/00 , C12P21/02 , C12R1/19 , C12N15/00 , C07K13/00 , A61K37/02 , A61K37/43 , C12N15/62
Abstract: Tumor necrosis factor (TNF) produced from the TNF molecule by modification at the amino terminus are prepared as described and are suitable for controlling diseases.
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公开(公告)号：CA2005053A1
公开(公告)日：1990-06-23
申请号：CA2005053
申请日：1989-12-11
Applicant: BASF AG
Inventor： DAUM LOTHAR , DOERPER THOMAS , HILLEN HEINZ , MOELLER ACHIM , SCHOLLMEIER KLAUS , WALKER NIGEL , KEILHAUER GERHARD
IPC: A61K38/00 , C07K14/525 , C12N1/21 , C12N15/28 , C12N15/63
Abstract: - 25 - O.Z. 0050/40432 of the disclosure: TNF polypeptides which differ from natural TNF by the replacement and/or deletion of amino acids are described. The novel polypeptides are suitable for controlling diseases.
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公开(公告)号：FI882283A0
公开(公告)日：1988-05-16
申请号：FI882283
申请日：1988-05-16
Applicant: BASF AG
Inventor： DOERPER THOMAS , MOELLER ACHIM , HILLEN HEINZ , KEILHAUER GERHARD , EMLING FRANZ , DAUM LOTHAR
IPC: C12N15/09 , A61K38/00 , A61P35/00 , C07K1/20 , C07K14/00 , C07K14/52 , C07K14/525 , C07K14/78 , C07K19/00 , C12P21/02 , C12R1/19 , C12N
Abstract: Tumor necrosis factor (TNF) produced from the TNF molecule by modification at the amino terminus are prepared as described and are suitable for controlling diseases.
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Patent Agency Ranking
公开(公告)号：DE10075019I1
公开(公告)日：2000-09-21
申请号：DE10075019
申请日：1990-05-04
Applicant: BASF AG
Inventor： LEMAIRE HANS-GEORG , HILLEN HEINZ , MOELLER ACHIM , DAUM LOTHAR , DOERPER THOMAS , SUBKOWSKI THOMAS
IPC: A61K35/22 , A61K38/00 , A61K38/17 , A61K38/19 , A61P7/00 , A61P7/02 , A61P7/04 , A61P11/00 , A61P19/00 , A61P19/02 , A61P19/08 , A61P25/00 , A61P29/00 , A61P31/04 , A61P37/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07K1/18 , C07K1/22 , C07K7/08 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/525 , C07K14/715 , C07K16/18 , C07K15/14
Abstract: PCT No. PCT/EP90/00719 Sec. 371 Date Sep. 26, 1991 Sec. 102(e) Date Sep. 26, 1991 PCT Filed May 4, 1990 PCT Pub. No. WO90/13575 PCT Pub. Date Nov. 15, 1990.Novel proteins which have a molecular weight of about 42,000 daltons and have at the N terminus the amino acid sequence Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Set Thr Cys Arg Leu Arg Glu where X is hydrogen, a phenylalanine residue (Phe) or the amino acid sequences Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe, and which are suitable for the treatment of diseases, are described.
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公开(公告)号：AT113063T
公开(公告)日：1994-11-15
申请号：AT90906924
申请日：1990-05-04
Applicant: BASF AG
Inventor： LEMAIRE HANS-GEORG , HILLEN HEINZ , MOELLER ACHIM , DAUM LOTHAR , DOERPER THOMAS , SUBKOWSKI THOMAS
IPC: A61K35/22 , A61K38/00 , A61K38/17 , A61K38/19 , A61P7/00 , A61P7/02 , A61P7/04 , A61P11/00 , A61P19/00 , A61P19/02 , A61P19/08 , A61P25/00 , A61P29/00 , A61P31/04 , A61P37/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07K1/18 , C07K1/22 , C07K7/08 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/525 , C07K14/715 , C07K16/18 , C07K15/14 , A61K35/12
Abstract: PCT No. PCT/EP90/00719 Sec. 371 Date Sep. 26, 1991 Sec. 102(e) Date Sep. 26, 1991 PCT Filed May 4, 1990 PCT Pub. No. WO90/13575 PCT Pub. Date Nov. 15, 1990.Novel proteins which have a molecular weight of about 42,000 daltons and have at the N terminus the amino acid sequence Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Set Thr Cys Arg Leu Arg Glu where X is hydrogen, a phenylalanine residue (Phe) or the amino acid sequences Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe, and which are suitable for the treatment of diseases, are described.
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公开(公告)号：ZA883428B
公开(公告)日：1990-01-31
申请号：ZA883428
申请日：1988-05-16
Applicant: BASF AG
Inventor： DOERPER THOMAS , THOMAS DOERPER , MOELLER ACHIM , ACHIM MOELLER , HILLEN HEINZ , HEINZ HILLEN , KEILHAUER GERHARD , GERHARD KEILHAUER , EMLING FRANZ , FRANZ EMLING , DAUM LOTHAR , LOTHAR DAUM
IPC: A61K38/00 , A61P35/00 , C07K1/20 , C12N15/09 , C07K14/00 , C07K14/52 , C07K14/525 , C07K14/78 , C07K19/00 , C12P21/02 , C12R1/19 , C07K , C07H , C12P
Abstract: Tumor necrosis factor (TNF) produced from the TNF molecule by modification at the amino terminus are prepared as described and are suitable for controlling diseases.
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公开(公告)号：AU590861B2
公开(公告)日：1989-11-16
申请号：AU7452187
申请日：1987-06-19
Applicant: BASF AG
Inventor： SCHOLLMEIER KLAUS , MOELLER ACHIM , KOERWER WOLFGANG , DOERPER THOMAS , HILLEN HEINZ , DAUM LOTHAR , EMLING FRANZ , KEILHAUER GERHARD
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公开(公告)号：DK263588A
公开(公告)日：1988-11-17
申请号：DK263588
申请日：1988-05-13
Applicant: BASF AG
Inventor： DOERPER THOMAS , MOELLER ACHIM , HILLEN HEINZ , KEILHAUER GERHARD , EMLING FRANZ , DAUM LOTHAR
IPC: C12N15/09 , A61K38/00 , A61P35/00 , C07K1/20 , C07K14/00 , C07K14/52 , C07K14/525 , C07K14/78 , C07K19/00 , C12P21/02 , C12R1/19 , C07K13/00 , C12N15/00
Abstract: Tumor necrosis factor (TNF) produced from the TNF molecule by modification at the amino terminus are prepared as described and are suitable for controlling diseases.
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