公开(公告)号：CA2208539C

公开(公告)日：2004-04-20

申请号：CA2208539

申请日：1995-12-22

Applicant: BASF AG

Inventor： MAIER WERNER ,  ROSENBERG JOERG ,  FRICKE HELMUT ,  BREITENBACH JORG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: the present invention concerns a method of producing divisible tablets by me lt calendering: two form cylinders are combined, one of the cylinders having at least one recess with at least one ridge which extends as far as the surface line of the cylinder and forms a break groove.

公开(公告)号：NO20012734L

公开(公告)日：2001-06-01

申请号：NO20012734

申请日：2001-06-01

Applicant: BASF AG

Inventor： BERTLEFF WERNER ,  BROECKEL ULRICH ,  FRICKE HELMUT ,  HARZ HANS-PETER ,  WITT REINER

IPC: A61K20060101 ,  A61K9/16 ,  A61K9/14 ,  A61K9/20 ,  A61K9/50 ,  A61K9/62 ,  A61K9/64 ,  B01J2/00 ,  B01J2/10 ,  B01J2/28

Abstract: A process for producing agglomerates with a core/shell structure, in which i) initial agglomerates containing a first particulate solid are prepared; ii) a second particulate solid is agglomerated in the presence of the initial agglomerates with the addition of a binder liquid to give second stage agglomerates and, where appropriate, iii) an nth (n>=3) solid is agglomerated in the presence of the (n-1)th stage agglomerates with the addition of a binder liquid to give nth stage agglomerates.

公开(公告)号：NO20012734D0

公开(公告)日：2001-06-01

申请号：NO20012734

申请日：2001-06-01

Applicant: BASF AG

Inventor： BERTLEFF WERNER ,  BROECKEL ULRICH ,  FRICKE HELMUT ,  HARZ HANS-PETER ,  WITT REINER

IPC: A61K20060101 ,  A61K9/16 ,  A61K9/14 ,  A61K9/20 ,  A61K9/50 ,  A61K9/62 ,  A61K9/64 ,  B01J2/00 ,  B01J2/10 ,  B01J2/28 ,  A61K

Abstract: A process for producing agglomerates with a core/shell structure, in which i) initial agglomerates containing a first particulate solid are prepared; ii) a second particulate solid is agglomerated in the presence of the initial agglomerates with the addition of a binder liquid to give second stage agglomerates and, where appropriate, iii) an nth (n>=3) solid is agglomerated in the presence of the (n-1)th stage agglomerates with the addition of a binder liquid to give nth stage agglomerates.

公开(公告)号：PL178357B1

公开(公告)日：2000-04-28

申请号：PL32087595

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  MAIER WERNER ,  FRICKE HELMUT ,  BREITENBACH JOERG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: PCT No. PCT/EP95/05117 Sec. 371 Date Jun. 18, 1997 Sec. 102(e) Date Jun. 18, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/19962 PCT Pub. Date Jul. 4, 1996A process for the production of divisible tablets by melt calendering in which two molding rolls are combined together, at least one of which has depressions with at least one bar which extends up to the surface line of the molding roll and forms a score.

公开(公告)号：DE59503813D1

公开(公告)日：1998-11-05

申请号：DE59503813

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  MAIER WERNER ,  FRICKE HELMUT ,  BREITENBACH JOERG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: PCT No. PCT/EP95/05117 Sec. 371 Date Jun. 18, 1997 Sec. 102(e) Date Jun. 18, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/19962 PCT Pub. Date Jul. 4, 1996A process for the production of divisible tablets by melt calendering in which two molding rolls are combined together, at least one of which has depressions with at least one bar which extends up to the surface line of the molding roll and forms a score.

公开(公告)号：SK76997A3

公开(公告)日：1998-02-04

申请号：SK76997

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JORG ,  MAIER WERNER ,  FRICKE HELMUT ,  BREITENBACH JORG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: The present invention concerns a method of producing divisible tablets by melting the mixture containing one or more pharmaceutically active substances and one or more additive substances; and by calendering the melting with two rotating form cylinders with the cavities for suppression and forming the melting to the tablets. Device for suppression and forming of the melting to the tablets comprises at least one form cylinder (6, 8) with cavities (2) divided by at least one ridge (7) which extends as far as the surface line of the cylinder and forms a break groove.

公开(公告)号：MX9704625A

公开(公告)日：1997-09-30

申请号：MX9704625

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JORG ,  MAIER WERNER ,  FRICKE HELMUT ,  BREITENBACH JORG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16 ,  A61J03/10 ,  A61K09/20

Abstract: La presente invencion se refiere a un proceso para la produccion de tabletas divisibles mediante calandrado por fusion en el que 2 rodillos de moldeo se combinan juntos, por lo menos uno de los cuales tiene depresiones con por lo menos una barra que se extiende hasta la línea superficial del rodillo de moldeo y forma un registro.

公开(公告)号：NO972912A

公开(公告)日：1997-08-19

申请号：NO972912

申请日：1997-06-20

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  MAIER WERNER ,  FRICKE HELMUT ,  BREITENBACH JOERG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16 ,  A61J3/06

CPC classification number: B30B11/165 ,  A61J3/10 ,  A61K9/2072 ,  Y10S53/90

公开(公告)号：FI972631A0

公开(公告)日：1997-06-18

申请号：FI972631

申请日：1997-06-18

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  MAIER WERNER ,  FRICKE HELMUT ,  BREITENBACH JOERG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16 ,  A61J

Abstract: PCT No. PCT/EP95/05117 Sec. 371 Date Jun. 18, 1997 Sec. 102(e) Date Jun. 18, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/19962 PCT Pub. Date Jul. 4, 1996A process for the production of divisible tablets by melt calendering in which two molding rolls are combined together, at least one of which has depressions with at least one bar which extends up to the surface line of the molding roll and forms a score.

公开(公告)号：AT261718T

公开(公告)日：2004-04-15

申请号：AT99962207

申请日：1999-12-03

Applicant: BASF AG

Inventor： BERTLEFF WERNER ,  BROECKEL ULRICH ,  FRICKE HELMUT ,  HARZ HANS-PETER ,  WITT REINER

IPC: A61K9/16 ,  A61K20060101 ,  A61K9/14 ,  A61K9/20 ,  A61K9/50 ,  A61K9/62 ,  A61K9/64 ,  B01J2/00 ,  B01J2/10 ,  B01J2/28

Abstract: A process for producing agglomerates with a core/shell structure, in which i) initial agglomerates containing a first particulate solid are prepared; ii) a second particulate solid is agglomerated in the presence of the initial agglomerates with the addition of a binder liquid to give second stage agglomerates and, where appropriate, iii) an nth (n>=3) solid is agglomerated in the presence of the (n-1)th stage agglomerates with the addition of a binder liquid to give nth stage agglomerates.