公开(公告)号：CA2408915C

公开(公告)日：2010-07-27

申请号：CA2408915

申请日：2001-05-29

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  BREITENBACH JORG ,  HEGER ROBERT ,  STADLER MICHAEL ,  WILKE PETER ,  ROSENBERG JORG

IPC: A61F13/53 ,  A61K9/107 ,  A23P1/02 ,  A23P1/08 ,  A61F13/49 ,  A61K9/16 ,  A61K47/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38

Abstract: The invention relates to self-emulsifying formulations based on an active substance constituent and on a formulation base with a lipid constituent and with a binding agent constituent. The invention also relates to the use of this formulation as a dosed form in the area of life science. The invention also relates to a method for producing self-emulsifying formulations by mixing the formulation constituents while forming a plastic mixture and optionally while preparing the formulations as a dosed form, advantageously while using melt extrusion. The formulations spontaneously form emulsions in water or in aqueous fluids.

公开(公告)号：CA2298659C

公开(公告)日：2007-09-11

申请号：CA2298659

申请日：1998-07-21

Applicant: BASF AG

Inventor： NEUMANN JORG ,  LIEPOLD BERND ,  VOLLGRAF CHRISTIANE ,  ROSENBERG JORG ,  ZEIDLER JURGEN ,  BREITENBACH JORG ,  BERNDL GUNTHER

IPC: A61K31/192 ,  A61J3/00 ,  A61K9/20 ,  A61K47/02 ,  A61K47/22 ,  A61K47/32 ,  A61P29/00

Abstract: The invention relates to a fast acting analgesic, containing ibuprofen as th e active analgesic substance in an auxiliary substance matrix, with a porous structure and a density of greater than 1 - 2.5 g/cm3.

公开(公告)号：SK282275B6

公开(公告)日：2002-01-07

申请号：SK76997

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JORG ,  MAIER WERNER ,  FRICKE HELMUT ,  BREITENBACH JORG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: PCT No. PCT/EP95/05117 Sec. 371 Date Jun. 18, 1997 Sec. 102(e) Date Jun. 18, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/19962 PCT Pub. Date Jul. 4, 1996A process for the production of divisible tablets by melt calendering in which two molding rolls are combined together, at least one of which has depressions with at least one bar which extends up to the surface line of the molding roll and forms a score.

公开(公告)号：AU6603301A

公开(公告)日：2001-12-11

申请号：AU6603301

申请日：2001-05-29

Applicant: BASF AG

Inventor： ROSENBERG JORG ,  BREITENBACH JORG ,  HERR DIETER ,  LAUX VOLKER ,  HEGER ROBERT

IPC: A61K47/12 ,  A61K9/16 ,  A61K31/726 ,  A61K31/727 ,  A61K47/14 ,  A61K47/30 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K47/44 ,  A61P1/04 ,  A61P7/02 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P37/06 ,  A61K9/48

公开(公告)号：CA2368138A1

公开(公告)日：2000-10-05

申请号：CA2368138

申请日：2000-03-17

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  LIEPOLD BERND ,  ROSENBERG JORG ,  BREITENBACH JORG

IPC: A61K47/10 ,  A61K9/16 ,  A61K9/20 ,  A61K47/14 ,  A61K47/34 ,  A61P31/10 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00

Abstract: The invention relates to mechanically stable pharmaceutical presentation for ms for peroral administration which in addition to one or more active ingredien ts and at least one thermoplastically mouldable matrix-forming auxiliary contai n more than 10 and up to 40 % by weight of a surface-active substance which ha s an HLB of between 2 and 18 and is liquid at 20 ~C or has a dropping point at between 20 and 50 ~C.

公开(公告)号：CA2298659A1

公开(公告)日：1999-02-11

申请号：CA2298659

申请日：1998-07-21

Applicant: BASF AG

Inventor： ZEIDLER JURGEN ,  ROSENBERG JORG ,  BREITENBACH JORG ,  BERNDL GUNTHER ,  VOLLGRAF CHRISTIANE ,  NEUMANN JORG ,  LIEPOLD BERND

IPC: A61K9/20 ,  A61K31/192 ,  A61K47/02 ,  A61K47/32 ,  A61P29/00 ,  A61K31/19

Abstract: The invention relates to a fast-acting analgesic, containing ibuprofen as the active analgesic substance in an auxiliary substance matrix, with a porous structure and a density of greater than 1 - 2.5 g/cm3.

公开(公告)号：CA2368138C

公开(公告)日：2006-08-22

申请号：CA2368138

申请日：2000-03-17

Applicant: BASF AG

Inventor： ROSENBERG JORG ,  LIEPOLD BERND ,  BERNDL GUNTHER ,  BREITENBACH JORG

IPC: A61K9/20 ,  A61K47/10 ,  A61K9/16 ,  A61K47/14 ,  A61K47/34 ,  A61P31/10 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00

Abstract: The invention relates to mechanically stable pharmaceutical presentation for ms for peroral administration which in addition to one or more active ingredien ts and at least one thermoplastically mouldable matrix-forming auxiliary contai n more than 10 and up to 40 % by weight of a surface-active substance which ha s an HLB of between 2 and 18 and is liquid at 20 ~C or has a dropping point at between 20 and 50 ~C.

公开(公告)号：AU4434196A

公开(公告)日：1996-07-19

申请号：AU4434196

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JORG ,  MAIER WERNER ,  FRICKE HELMUT ,  BREITENBACH JORG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: PCT No. PCT/EP95/05117 Sec. 371 Date Jun. 18, 1997 Sec. 102(e) Date Jun. 18, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/19962 PCT Pub. Date Jul. 4, 1996A process for the production of divisible tablets by melt calendering in which two molding rolls are combined together, at least one of which has depressions with at least one bar which extends up to the surface line of the molding roll and forms a score.

公开(公告)号：SK76997A3

公开(公告)日：1998-02-04

申请号：SK76997

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JORG ,  MAIER WERNER ,  FRICKE HELMUT ,  BREITENBACH JORG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: The present invention concerns a method of producing divisible tablets by melting the mixture containing one or more pharmaceutically active substances and one or more additive substances; and by calendering the melting with two rotating form cylinders with the cavities for suppression and forming the melting to the tablets. Device for suppression and forming of the melting to the tablets comprises at least one form cylinder (6, 8) with cavities (2) divided by at least one ridge (7) which extends as far as the surface line of the cylinder and forms a break groove.

公开(公告)号：MX9704625A

公开(公告)日：1997-09-30

申请号：MX9704625

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JORG ,  MAIER WERNER ,  FRICKE HELMUT ,  BREITENBACH JORG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16 ,  A61J03/10 ,  A61K09/20

Abstract: La presente invencion se refiere a un proceso para la produccion de tabletas divisibles mediante calandrado por fusion en el que 2 rodillos de moldeo se combinan juntos, por lo menos uno de los cuales tiene depresiones con por lo menos una barra que se extiende hasta la línea superficial del rodillo de moldeo y forma un registro.