公开(公告)号：BR0010167A

公开(公告)日：2002-06-04

申请号：BR0010167

申请日：2000-04-17

Applicant: BASF AG

Inventor： DETERING JUERGEN ,  BERTLEFF WERNER ,  WAGENBLAST GERHARD ,  OTT CHRISTIAN ,  KAPPES ELISABETH ,  HABECK THORSTEN

IPC: C07C235/34 ,  C08F8/00 ,  C08G73/02 ,  C11D3/00 ,  C11D3/37 ,  C11D3/42 ,  D06L3/12 ,  D06L4/60 ,  D06M13/123 ,  D06M13/224 ,  D06M13/372 ,  D06M13/402 ,  D06M13/41 ,  D06M13/415 ,  D06M13/419 ,  D06M13/46 ,  D06M15/356 ,  D06M15/59 ,  D06M15/61 ,  D06P5/06 ,  D06P5/08 ,  C07C255/41

公开(公告)号：DE10037846A1

公开(公告)日：2002-02-14

申请号：DE10037846

申请日：2000-08-01

Applicant: BASF AG

Inventor： HAREMZA SYLKE ,  PRECHTL FRANK ,  HABECK THORSTEN

IPC: A61K8/49 ,  A61Q17/00 ,  A61Q17/04 ,  C07D311/22 ,  C07D311/30 ,  C07D405/04 ,  C07D405/06 ,  C07D407/06 ,  A61K7/00 ,  A61K7/48

Abstract: Flavonoids substituted by phenyl, pyridyl, furyl or methylpyrrolyl groups are new, the phenyl or heterocyclic substituents optionally being bonded via unsaturated groups. Flavonoids of formula (I) are new. R = a group of formula (Ia) or Ib); R = H, 1-4C alkyl, hydroxy, 1-4C alkoxy, phenyloxy or benzyloxy; R = H or 1-4C alkyl; R = H, 1-4C alkyl, 1-4C alkoxy or cyano; R = H, 1-4C alkyl or phenyl; n = 0 or 1; and Het = pyridyl, furyl or methylpyrrolyl, with the proviso that when R is (IA) and n = 0, at least two of R - R are H.

公开(公告)号：BR0102324A

公开(公告)日：2001-12-04

申请号：BR0102324

申请日：2001-03-15

Applicant: BASF AG

Inventor： HEIDENFELDER THOMAS ,  HABECK THORSTEN ,  WUENSCH THOMAS

IPC: A61K8/00 ,  A61K8/35 ,  A61K8/36 ,  A61K8/37 ,  A61K8/49 ,  A61K8/89 ,  A61K8/893 ,  A61K8/896 ,  A61K8/898 ,  A61K31/121 ,  A61K31/216 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/53 ,  A61K31/695 ,  A61K31/77 ,  A61K33/24 ,  A61K33/30 ,  A61P17/16 ,  A61Q1/04 ,  A61Q17/04 ,  C08L83/07 ,  A61K7/42

公开(公告)号：DE10015086A1

公开(公告)日：2001-10-04

申请号：DE10015086

申请日：2000-03-28

Applicant: BASF AG

Inventor： HEIDENFELDER THOMAS ,  WAGENBLAST GERHARD ,  DETERING JUERGEN ,  HABECK THORSTEN

IPC: C11D3/26 ,  A61K8/40 ,  A61Q17/04 ,  C09K3/00 ,  C11D3/42 ,  D06L3/12 ,  D06L4/614 ,  D06L4/65 ,  D06L4/657 ,  D06M13/07 ,  D06M13/127 ,  D06M13/152 ,  D06M13/224 ,  D06M13/352 ,  D06M13/358 ,  D06M13/372 ,  D06P1/642 ,  D06P1/651 ,  D06P5/04 ,  D06P5/08 ,  D06M13/348

Abstract: The invention relates to a mixture, comprising (A) 10 to 90 wt. % of at least one C6 to C18 alkyl ester, or C5 to C8 cycloalkyl ester of 2-cyano-3,3-diphenylacrylic acid and (B) 90 to 10 wt. % of at least one further compound, with at least one UV absorption maximum in the range 280 to 450 nm and structurally different from compound (A). Said mixture is suitable for the protection of human skin from damaging UV radiation and for the protection of coloured textile materials from colour fading.

公开(公告)号：DE10012413A1

公开(公告)日：2001-09-20

申请号：DE10012413

申请日：2000-03-15

Applicant: BASF AG

Inventor： HEIDENFELDER THOMAS ,  HABECK THORSTEN ,  WUENSCH THOMAS

IPC: A61K8/00 ,  A61K8/35 ,  A61K8/36 ,  A61K8/37 ,  A61K8/49 ,  A61K8/89 ,  A61K8/893 ,  A61K8/896 ,  A61K8/898 ,  A61K31/121 ,  A61K31/216 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/53 ,  A61K31/695 ,  A61K31/77 ,  A61K33/24 ,  A61K33/30 ,  A61P17/16 ,  A61Q1/04 ,  A61Q17/04 ,  C08L83/07 ,  A61K7/40 ,  A61K7/42

公开(公告)号：DE19928033A1

公开(公告)日：2000-12-21

申请号：DE19928033

申请日：1999-06-18

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  PRECHTL FRANK ,  WUENSCH THOMAS ,  WESTENFELDER HORST

IPC: C07D233/64 ,  A61K8/00 ,  A61K8/02 ,  A61K8/06 ,  A61K8/49 ,  A61K47/22 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07D239/70 ,  C07D263/56 ,  C07D277/64 ,  A61K7/40

Abstract: Use of new and known bicyclic and tricyclic enamines as UV filters in cosmetic and pharmaceutical preparations is new. Also new is their use for the protection of plastics. Use of bicyclic and tricyclic enamines as UV filters in cosmetic and pharmaceutical preparations is new. R and R = CN; alkylcarbonyl; alkoxycarbonyl; aryloxycarbonyl; or optionally substituted aminocarbonyl; R = H; 1-20C alkyl; 3-20C cycloalkyl; or -CH2-CH2-SO3 M ; M = cation; X = -O-; -S-; or -N(R )-; Z' = group of formula (ii) or (iii): R = H; alkyl, cycloalkyl, alkoxy, cycloalkoxy, alkoxycarbonyl, alkyl-NH-CO-, (alkyl)2-NH-CO-, alkyl-NH- or (alkyl)2N- (each with up to 20C); CN; NH2; or SO3 M and more than 1 R can be present. Independent claims are also included for: (1) the use of compounds (I) as light screening agents for the protection of plastics; (2) (I; Z' = (iii); and (3) (I; Z' = (ii); R4 = R40; R1, R2 = R10, R20 respectively) R and R = CN or 2-10C alkoxycarbonyl optionally substituted with -(CH2)n-SO3 M ; R = H; CH3; or -(CH2)n-SO3 M ; R = H; 1-8C alkyl; 1-8C alkoxy; or -SO3 M ; n = 2 or 3; M = H or HN(R )(R )(R ) ; R -R = H lower alkyl optionally substituted with OH; or a metal cation; but at least one -(CH2)n-SO3 M or -SO3 M must be present.

公开(公告)号：AU3315699A

公开(公告)日：1999-12-16

申请号：AU3315699

申请日：1999-06-03

Applicant: BASF AG

Inventor： SCHUHMACHER PETER ,  SCHNEIDER NORBERT ,  WESTENFELDER HORST ,  HAREMZA SYLKE ,  HABECK THORSTEN ,  MEYER FRANK

IPC: A61K8/00 ,  A61K8/02 ,  A61K8/23 ,  A61K8/25 ,  A61K8/29 ,  A61K8/31 ,  A61K8/33 ,  A61K8/34 ,  A61K8/36 ,  A61K8/37 ,  A61K8/41 ,  A61K8/46 ,  A61K8/49 ,  A61K8/73 ,  A61K8/86 ,  A61K8/89 ,  A61K8/97 ,  A61K8/98 ,  A61K31/255 ,  A61K31/34 ,  A61P17/16 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q1/10 ,  A61Q5/00 ,  A61Q17/04 ,  A61Q19/00 ,  C09B67/20 ,  C09C3/08 ,  C09K3/00 ,  A61K7/027 ,  A61K7/021 ,  A61K7/42

Abstract: Liquid crystal compositions forming a cholesteric phase with a pitch of less than 450 nm, comprising either at least one polymerizable chiral liquid crystal monomer or a mixture of at least one polymerizable achiral liquid crystal monomer and at least one chiral additive, are used as ultraviolet filters for protecting skin or hair against solar radiation. Liquid crystal compositions forming a cholesteric phase with a pitch of less than 450 nm, comprising either: (a) at least one polymerizable chiral liquid crystal monomer of formula (I); or (b) a mixture of at least one polymerizable achiral liquid crystal monomer of formula (II) and at least one chiral additive, are used as ultraviolet (UV) filters in cosmetic and pharmaceutical compositions for protecting human skin or hair against solar radiation: A -A = spacers with a chain length of 1-30C; Y -Y = bonds, O, S, C(O)O, OC(O), CH=CHC(O)O, OC(O)O, C(O)N(R), N(R)C(O), CH2O, OCH2, CH=N, N=CH or N=N; M , M = mesogenic groups; R = H or 1-4C alkyl; Z = H, 1-4C alkyl or a polymerizable group, at least one being a polymerizable group; Z , Z = H, 1-4C alkyl or polymerizable groups, at least one being a polymerizable group; X = an n-valent chiral group; m, o, p = 0 or 1; n = 1-6. Independent claims are also included: (1) use of the liquid crystal compositions as photostable UV reflectors; (2) use of the liquid crystal compositions as UV stabilizers in cosmetic and pharmaceutical formulations; (3) pigments containing the polymerized liquid crystal compositions.

公开(公告)号：DE19806241A1

公开(公告)日：1999-08-19

申请号：DE19806241

申请日：1998-02-16

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  KRAUSE ALFRED

IPC: C07D319/06 ,  A61K8/00 ,  A61K8/49 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q5/00 ,  A61Q17/04 ,  C07D319/08 ,  C07D409/06 ,  A61K7/42 ,  A61K7/48

Abstract: Cyclic malonic ester derivatives (i.e. 1,3-dioxan-4,6-dione) derivatives of formula (I) are used to protect skin and hair against the damaging effects of sunlight. Use of cyclic malonic ester derivatives of formula (I) as photostable ultraviolet (UV) filters in cosmetic and pharmaceutical preparations for protection of human skin or hair against sunlight, optionally in combination with compounds which absorb in the UV region and which have been used in cosmetic and pharmaceutical preparations, is new. R , R = H or 1-20C alkyl; or CR R = a 5-12C ring; R = a group of formula (i) or (ii): R = H, 1-20C alkyl or a group of formula (i); R -R = H, OH, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, 1-12C alkoxy, 1-20C alkoxycarbonyl, 1-12C alkylamino, 1-12C dialkylamino, aryl, heteroaryl, or an optionally substituted group (selected from carboxylate, sulfonate and ammonium residues) which imparts water solubility; X = O, S or NH; n = 0 or 1.

公开(公告)号：AU9718198A

公开(公告)日：1999-07-08

申请号：AU9718198

申请日：1998-12-17

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  HAREMZA SYLKE ,  TRAUTH HUBERT ,  SCHEHLMANN VOLKER ,  WESTENFELDER HORST

IPC: A61K8/49 ,  A61K8/00 ,  A61K31/4035 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07D209/46 ,  C08K5/3417 ,  C08L101/00 ,  C09D7/12 ,  C09K3/00 ,  C09K15/30 ,  C08K5/3447 ,  A61K47/22

Abstract: Use of isoindolinone derivatives of formula (I) as stabilizers for organic materials is new, where: R = H, COOR , COR , CONR R , CN, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, aryl or heteroaryl (optionally substituted); R = COOR , COR , CONR R or CN; or R +R = 7-10C bicycloalkyl or 7-10C bicycloalkenyl; R = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, 1-12C alkoxy, 1-20C alkoxycarbonyl, 1-12C alkylamino, 1-12C dialkylamino, aryl, heteroaryl (optionally substituted) or a water-solubilizing carboxylate, sulfonate or alkylammonium group; R and R = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, aryl or heteroaryl (optionally substituted). An Independent claim is included for compounds (I) as medicaments.

公开(公告)号：DE19634229A1

公开(公告)日：1998-02-26

申请号：DE19634229

申请日：1996-08-23

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  AUMUELLER ALEXANDER ,  SCHEHLMANN VOLKER ,  WESTENFELDER HORST ,  WUENSCH THOMAS

IPC: A61K8/00 ,  A61K8/30 ,  A61K8/40 ,  A61K8/49 ,  A61K8/92 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07C255/40 ,  C07D307/52 ,  C07D317/54 ,  C07D333/24 ,  A61K7/42

Abstract: The use of compounds of formula (I) as UV-A filters in cosmetic products (optionally in combination with standard UV absorbers) to protect the human skin against sunlight is claimed. R1-R3 = H or (cyclo)aliphatic group containing up to 18 C, or two of these groups can combine to form a 5 or 6-membered ring ; R4 = optionally substituted (hetero)aryl containing 5-12 ring atoms ; and R5 = R4 or H. Also claimed are (i) cosmetic products containing (I) for protecting the epidermis layer against UV radiation with a wavelength of 280-400 nm and (ii) compounds of formula (II) : R7-R9 = lower alkyl ; R6 = 2-thienyl (optionally substituted with lower alkyl), 4-(3,5-di-t-butyl)-1-hydroxyphenyl or 4-(3,5-di-t-butyl)-1-alkoxyphenyl.