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    Mevalonate kinase as a target for fungicides
    13.
    发明专利
    Mevalonate kinase as a target for fungicides 未知

    公开(公告)号：AU2004209042A1

    公开(公告)日：2004-08-19

    申请号：AU2004209042

    申请日：2004-01-28

    Applicant: BASF AG

    Inventor： FREUND ANNETTE ,  LACOUR THIERRY ,  RETHER JAN

    IPC: C12N9/12 ,  C12N15/54 ,  G01N33/50 ,  C12Q1/02

    Abstract: The present invention relates to the provision of mevalonate kinase as target for fungicides, to the provision of novel nucleic acid sequences, of functional equivalents of the abovementioned nucleic acid sequences and to the use of the gene products of the abovementioned nucleic acid sequences as novel targets for fungicides. Moreover, the present invention relates to methods for identifying fungicides which inhibit a polypeptide with the biological activity of a mevalonate kinase and to the use of these compounds identified via the abovementioned method as fungicides.

    Proteins of the ubiquitin proteosome metabolic pathway, useful as targets for identifying fungicides for use in plant protection, also new nucleic acids, proteins and fungicides
    14.
    发明专利
    Proteins of the ubiquitin proteosome metabolic pathway, useful as targets for identifying fungicides for use in plant protection, also new nucleic acids, proteins and fungicides 未知

    公开(公告)号：DE10232773A1

    公开(公告)日：2004-02-05

    申请号：DE10232773

    申请日：2002-07-18

    Applicant: BASF AG

    Inventor： FREUND ANNETTE ,  LACOUR THIERRY ,  RETHER JAN

    IPC: C07K14/37 ,  C07K14/435 ,  A61K38/17 ,  C12N15/11 ,  C12Q1/68

    Abstract: Use of proteins (I) of the ubiquitin proteosome metabolic pathway as targets for fungicides. (I) are encoded by: (a) any of 9 sequences (X; 444-1266 bp), reproduced; (b) sequences (Y) derived by reverse translation, within the degeneracy of the genetic code, from 9 protein sequences (Z), reproduced; or (c) functional equivalents of (a) or (b), having at least 60% identity. Independent claims are also included for the following: (1) new nucleic acid sequences (IIa) that are (X), (Y) and functional equivalents having 65-86% identity with (X) or 71-98% identity with (Y), with the precise minimal degree of identity being specified for each sequence, individually; (2) polypeptides (Ia) encoded by (IIa); (3) method for detecting functional analogs of (X) by preparing a probe and then screening a genomic or cDNA library from the appropriate species, or by computer-based searching for analogs in electronic databases; (4) method for identifying mutations in (I); (5) expression cassette (EC) comprising control sequences linked to (IIa) and/or additional functional elements; (6) vector that contains EC; (7) non-human transgenic organism (bacterium, yeast, fungus or animal or plant cell) that contains (IIa), EC or the vector of (6); (8) method for identifying fungicides; (9) carrier for use in the new methods comprising (IIa), vectors of (6), hosts of (7) and (Ia); and (10) fungicides identified by method (8).

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