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公开(公告)号：WO2004022776A3
公开(公告)日：2004-07-08
申请号：PCT/EP0309369
申请日：2003-08-23
Applicant: BASF AG , FREUND ANNETTE , ROEHL FRANZ , ALTHOEFER HENNING , KAROS MARVIN , KAESLER BRUNO , LACOUR THIERRY
Inventor： FREUND ANNETTE , ROEHL FRANZ , ALTHOEFER HENNING , KAROS MARVIN , KAESLER BRUNO , LACOUR THIERRY
CPC classification number: A01N61/00 , A01N43/90 , C12N9/78 , C12Q1/34 , C12Y305/04025 , G01N2500/02
Abstract: The present invention relates to inhibition of GTP cyclohydrolase II as target for the identification of fungicides. Binding assays are claimed and coupled enzymatic assays are disclosed involving the conversion of formate (product of the reaction catalyzed by GTP-cyclohydrolases) by formate dehydrogenase and spectroscopically measuring the NADH formed. Furthermore in vivo assays with organisms containing a GTP-cyclohydrolase II are claimed as well as a DNA sequence for a fungal GTP-cyclohydrolase II. 3-Butyl-10-(3-chlorophenyl)- 10H-pyrimido[4,5-b]quinoline-2,4-dione is identified by the enzymatic method as a fungicide. Finally, methods of controlling fungi (e.g. on plants, in soil) by applying this agent are claimed.
Abstract translation: 本发明涉及抑制GTP环化水解酶II作为鉴定杀真菌剂的靶标。 公开了结合测定法，并公开了偶联的酶测定法，其涉及通过甲酸脱氢酶转化甲酸盐（由GTP-环化水解酶催化的反应产物）并光谱测量形成的NADH。 此外还要求具有含有GTP-环化水解酶II的生物体的体内测定以及用于真菌GTP-环化水解酶II的DNA序列。 通过酶法将3-丁基-10-（3-氯苯基）-10H-嘧啶并[4,5-b]喹啉-2,4-二酮鉴定为杀真菌剂。 最后，要求保护通过施用该试剂控制真菌（例如在土壤中的植物上）的方法。
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公开(公告)号：WO2004005522A3
公开(公告)日：2004-06-03
申请号：PCT/EP0307028
申请日：2003-07-02
Applicant: BASF AG , LACOUR THIERRY , RETHER JAN , FREUND ANNETTE , SCHAEFER WILHELM , MAIER FRANK , MALZ SASCHA
Inventor： LACOUR THIERRY , RETHER JAN , FREUND ANNETTE , SCHAEFER WILHELM , MAIER FRANK , MALZ SASCHA
CPC classification number: C12N15/80
Abstract: The invention relates to novel plasmid vectors for transformation of filamentous fungi and to a method of modifiying the genome of filamentous fungi based on these vectors. The invention furthermore relates to the modification of a specific gene via the process of homologous recombination, to recombinant expression of foreign genes in filamentous fungi and to new selection markers for detecting succesfull transfer of the target gene in filamentous fungi.
Abstract translation: 本发明涉及用于转化丝状真菌的新型质粒载体和基于这些载体修饰丝状真菌基因组的方法。 本发明还涉及通过同源重组的方法修饰特定基因，重组外源基因在丝状真菌中的表达，以及用于检测丝状真菌中靶基因成功转移的新选择标记。
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公开(公告)号：WO2005068635A3
公开(公告)日：2005-11-03
申请号：PCT/EP2004014826
申请日：2004-12-30
Applicant: BASF AG , LACOUR THIERRY , SCHAEFER WILHELM , MAIER FRANK
Inventor： LACOUR THIERRY , SCHAEFER WILHELM , MAIER FRANK
IPC: C07K14/37 , C07K14/39 , C07K14/435 , C12Q1/18 , C12Q1/68 , C12N15/52 , C12N9/02 , C12N15/80 , C12N15/81
CPC classification number: C12Q1/6897 , C07K14/37 , C07K14/39 , C12Q1/6895
Abstract: The present invention relates to the provision of expression cassettes and nucleic acid sequences and to the use of these aforementioned nucleic acid sequences in a method for identifying antifungal compounds, which inhibit the mitochondrial transport process in eucaryotes. Furthermore, the invention relates to the use of these compounds identified via the abovementioned method as fungicides.
Abstract translation: 本发明涉及提供表达盒和核酸序列，以及这些上述核酸序列用于鉴定抑制真核生物中的线粒体转运过程的抗真菌化合物的方法中的用途。 此外，本发明涉及通过上述方法鉴定的这些化合物作为杀真菌剂的用途。
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4.发明申请URIDYL GLUCOSE PYROPHOSPHORYLASE AS TARGET FOR FUNGICIDES 审中-公开URIDYL GLUCOSE PYROPHOSPHORYLASE作为目标用于杀真菌剂
公开(公告)号：WO2005005629A3
公开(公告)日：2005-02-10
申请号：PCT/EP2004007229
申请日：2004-07-02
Applicant: BASF AG , LACOUR THIERRY , RETHER JAN , FREUND ANNETTE , LOESCH ANKE , JENCZMIONKA NICOLE , SCHAEFER WILHELM , MAIER FRANK , MALZ SASCHA , SCHMIDT RALF-MICHAEL
Inventor： LACOUR THIERRY , RETHER JAN , FREUND ANNETTE , LOESCH ANKE , JENCZMIONKA NICOLE , SCHAEFER WILHELM , MAIER FRANK , MALZ SASCHA , SCHMIDT RALF-MICHAEL
CPC classification number: C12N9/1241 , C12Q1/48
Abstract: The present invention relates to the provision of a polypeptide with the enzymatic activity of a Uridyl glucose pyrophosphorylase as targets for fungicides, the provision of novel nucleic acid sequences encoding a polypeptide with the enzymatic activity of a Uridyl glucose pyrophosphorylase, the provision of functional equivalents of the aforementioned nucleic acid sequences, and use of a polypeptide with the enzymatic activity of a Uridyl glucose pyrophosphorylase encoded by a nucleic acid sequence in a method for identifying antifungal compounds. Furthermore, the invention relates to antifungal compounds identified by the abovementioned method and the use of these compounds as fungicides.
Abstract translation: 本发明涉及提供具有乌吡啶葡萄糖焦磷酸化酶作为杀真菌剂靶的酶活性的多肽，提供编码具有乌吡啶葡萄糖焦磷酸化酶的酶活性的多肽的新型核酸序列，提供功能等同物 上述核酸序列，以及在鉴定抗真菌化合物的方法中使用由核酸序列编码的乌吡啶葡萄糖焦磷酸化酶的酶活性的多肽。 此外，本发明涉及通过上述方法鉴定的抗真菌化合物和这些化合物作为杀真菌剂的用途。
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公开(公告)号：CA2514694A1
公开(公告)日：2004-08-19
申请号：CA2514694
申请日：2004-01-28
Applicant: BASF AG
Inventor： RETHER JAN , FREUND ANNETTE , LACOUR THIERRY , SCHMIDT RALF-MICHAEL
Abstract: The present invention relates to the provision of mevalonate kinase as target for fungicides, to the provision of novel nucleic acid sequences, of functional equivalents of the abovementioned nucleic acid sequences and to the use of the gene products of the abovementioned nucleic acid sequences as novel targets for fungicides. Moreover, the present invention relates to methods for identifying fungicides which inhibit a polypeptide with the biological activity of a mevalonate kinase and to the use of these compounds identified via the abovementioned method as fungicides.
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Patent Agency Ranking
公开(公告)号：AU2003258505A8
公开(公告)日：2004-01-23
申请号：AU2003258505
申请日：2003-07-02
Applicant: BASF AG
Inventor： MAIER FRANK , LACOUR THIERRY , FREUND ANNETTE , MALZ SASCHA , SCHAFER WILHELM , RETHER JAN
Abstract: The invention relates to novel plasmid vectors for transformation of filamentous fungi and to a method of modifiying the genome of filamentous fungi based on these vectors. The invention furthermore relates to the modification of a specific gene via the process of homologous recombination, to recombinant expression of foreign genes in filamentous fungi and to new selection markers for detecting succesfull transfer of the target gene in filamentous fungi.
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公开(公告)号：DE60314258T2
公开(公告)日：2008-02-07
申请号：DE60314258
申请日：2003-08-23
Applicant: BASF AG
Inventor： FREUND ANNETTE , ROEHL FRANZ , ALTHOEFER HENNING , KAROS MARVIN , KAESLER BRUNO , LACOUR THIERRY
Abstract: The present invention relates to methods for determining GTP Cyclohydrolase I or II activity in a sample.
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公开(公告)号：AU2003270098A8
公开(公告)日：2004-03-29
申请号：AU2003270098
申请日：2003-08-23
Applicant: BASF AG
Inventor： ROHL FRANZ , FREUND ANNETTE , KAROS MARVIN , LACOUR THIERRY , ALTHOFER HENNING , KAESLER BRUNO
Abstract: The present invention relates to methods for determining GTP Cyclohydrolase I or II activity in a sample.
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公开(公告)号：AU2003270098A1
公开(公告)日：2004-03-29
申请号：AU2003270098
申请日：2003-08-23
Applicant: BASF AG
Inventor： LACOUR THIERRY , FREUND ANNETTE , ROHL FRANZ , ALTHOFER HENNING , KAROS MARVIN , KAESLER BRUNO
Abstract: The present invention relates to methods for determining GTP Cyclohydrolase I or II activity in a sample.
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公开(公告)号：AU2003258505A1
公开(公告)日：2004-01-23
申请号：AU2003258505
申请日：2003-07-02
Applicant: BASF AG
Inventor： MAIER FRANK , MALZ SASCHA , LACOUR THIERRY , RETHER JAN , FREUND ANNETTE , SCHAFER WILHELM
IPC: C12N15/80
Abstract: The invention relates to novel plasmid vectors for transformation of filamentous fungi and to a method of modifiying the genome of filamentous fungi based on these vectors. The invention furthermore relates to the modification of a specific gene via the process of homologous recombination, to recombinant expression of foreign genes in filamentous fungi and to new selection markers for detecting succesfull transfer of the target gene in filamentous fungi.
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