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公开(公告)号:CA2419275A1
公开(公告)日:2002-03-07
申请号:CA2419275
申请日:2001-08-30
Applicant: BASF AG
Inventor: NUBLING CHRISTOPH , STURMER RAINER , LADNER WOLFGANG , FRIEDRICH THOMAS , HAUER BERNHARD
IPC: C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/16 , C12N9/18 , C12N15/55 , C12P7/62 , C12P41/00 , C12P7/00 , C12N1/20 , C12N15/63
Abstract: The invention relates to novel proteins exhibiting esterase activity, in particular butinol I esterase activity, obtained from Pseudomonas glumae and to nucleic acid sequences that code therefor, expression cassettes, vectors and recombinant microorganisms. The invention also relates to a method for producing said proteins and to the use thereof for the enzymatic, in particular, enantioselective ester hydrolysis or interesterification of organic esters.
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公开(公告)号:AU4039799A
公开(公告)日:2000-08-29
申请号:AU4039799
申请日:1999-05-10
Applicant: BASF AG
Inventor: RIECHERS HARTMUT , SIMON JOACHIM , HOHN ARTHUR , KRAMER ANDREAS DR , FUNKE FRANK , SIEGEL WOLFGANG , NUBLING CHRISTOPH
IPC: B01J23/88 , B01J23/755 , C07B55/00 , C07B57/00 , C07B61/00 , C07C209/00 , C07C209/68 , C07C209/86 , C07C209/88 , C07C211/03 , C07C213/08 , C07C217/08
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公开(公告)号:AU2001284047B2
公开(公告)日:2007-03-29
申请号:AU2001284047
申请日:2001-08-30
Applicant: BASF AG
Inventor: FRIEDRICH THOMAS , STURMER RAINER , LADNER WOLFGANG , HAUER BERNHARD , NUBLING CHRISTOPH
IPC: C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/16 , C12N9/18 , C12N15/55 , C12P7/62 , C12P41/00
Abstract: The invention relates to novel proteins from Pseudomonas glumae, having esterase activity, in particular butynol I esterase activity, to nucleic acid sequences coding therefore, to expression cassettes, vectors and recombinant microorganisms; to methods for preparing said proteins and to the use thereof for enzymic, in particular enantioselective enzymic, ester hydrolysis or transesterification of organic esters.
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14.
公开(公告)号:CA2210519C
公开(公告)日:2006-03-21
申请号:CA2210519
申请日:1996-01-20
Applicant: BASF AG
Inventor: NUBLING CHRISTOPH , BALKENHOHL FRIEDHELM , DITRICH KLAUS
Abstract: A process for preparing optically active primary and secondary heteroatom- substituted amines from the corresponding racemates is characterised in that (a) a racemic heteroatom-substituted amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bear a fluorine, nitrogen, phosphorus, oxygen or sulphu r atom next to the carbonyl carbon atom; (b) the mixture of optically active heteroatom-substituted amine and optically active acylated heteroatom-substituted amine is separated in order to produce an enantiomer of the heteroatom-substituted amine; (c) the other enantiomer of the heteroatom-substituted amine is optionally extracted from the acylated heteroatom-substituted amine by amide cleavage.
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公开(公告)号:CA2217880C
公开(公告)日:2004-02-24
申请号:CA2217880
申请日:1996-05-07
Applicant: BASF AG
Inventor: NUBLING CHRISTOPH , LADNER WOLFGANG
IPC: C07C213/02 , C07C213/08 , C07C213/10 , C07C217/52 , C07C233/23 , C07C271/24 , C07C271/56 , C07C215/44
Abstract: A process for preparing enantiomerically pure cis-1-amino- 2-hydroxyindan, which comprises a) converting racemic trans-1-aminoindan-2-ol with acids or acid derivatives of the general formula RCOX by conventional methods into amides of type A where the substituents have the following meanings: R is hydrogen, C1-C6-alkyl, C3-C6-cycloalkyl and phenyl, it being possible for these groups to carry one to three halogen atoms and/or one to three of the following radicals: cyano, C1-C6-alkoxy, C1-C6-alkylthio, phenyl, phenylthio and phenoxy, it being possible for the phenyl radicals in turn to carry one to three of the following groups: C1-C4-alkyl, C1-C4-alkoxy, halogen, cyano and nitro, X is OH, halogen, OR1 and SR1, where R1 is C1-C6-alkyl, phenyl and COR, b) adding seed crystals of one enantiomer to a supersaturated solution or melt of the racemic amide A, c) isolating the crystals which have separated out, and again supersaturating the remaining mother liquor or melt after dissolving racemic amide A, and adding seed crystals of the other enantiomer, leading to selective crystallization of the latter, d) converting the resulting enantiomerically pure traps amide by conventional methods into the enantiomerically pure cis-1-amino-2-hydroxyindan.
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公开(公告)号:PT801683E
公开(公告)日:2002-09-30
申请号:PT96900601
申请日:1996-01-20
Applicant: BASF AG
Inventor: BALKENHOHL FRIEDHELM , DITRICH KLAUS , NUBLING CHRISTOPH
Abstract: A process for preparing optically active primary and secondary heteroatom-substituted amines from the corresponding racemates, which comprisesa) enantioselective acylation of a racemic heteroatom-substituted amine with an ester whose acid component carries a fluorine, nitrogen, phosphorus, oxygen or sulfur atom in the vicinity of the carbonyl carbon, in the presence of a hydrolase,b) separation of the mixture of optically active heteroatom-substituted amine and optically active acylated heteroatom-substituted amine to obtain one enantiomer of the heteroatom-substituted amine,c) if required isolation of the other enantiomer of the heteroatom-substituted amine from the acylated heteroatom-substituted amine by amide cleavage.
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公开(公告)号:PT824512E
公开(公告)日:2001-04-30
申请号:PT96915021
申请日:1996-05-07
Applicant: BASF AG
Inventor: LADNER WOLFGANG , NUBLING CHRISTOPH
IPC: C07C213/02 , C07C213/08 , C07C213/10 , C07C217/52 , C07C233/23 , C07C271/24 , C07C271/56
Abstract: PCT No. PCT/EP96/01884 Sec. 371 Date Oct. 28, 1997 Sec. 102(e) Date Oct. 28, 1997 PCT Filed May 7, 1996 PCT Pub. No. WO96/35660 PCT Pub. Date Nov. 14, 1996A process for preparing enantiomerically pure cis-1-amino-2-hydroxyindane, which comprises a) converting racemic trans-1-aminoindan-2-ol with acids or acid derivatives of the general formula RCOX by conventional methods into amides of type A A b) adding seed crystals of one enantiomer to a super-saturated solution or melt of the racemic amide A, c) isolating the crystals which have separated out, and again supersaturating the remaining mother liquor or melt after dissolving racemic amide A, and adding seed crystals of the other enantiomer, leading to selective crystallization of the latter, d) converting the resulting enantiomerically pure trans amide by conventional methods into the enantiomerically pure cis-1-amino-2-hydroxyindane.
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公开(公告)号:CA2362365A1
公开(公告)日:2000-08-17
申请号:CA2362365
申请日:1999-05-10
Applicant: BASF AG
Inventor: FUNKE FRANK , SIEGEL WOLFGANG , NUBLING CHRISTOPH , KRAMER ANDREAS , RIECHERS HARTMUT , SIMON JOACHIM , HOHN ARTHUR
IPC: B01J23/755 , C07B55/00 , C07B57/00 , C07B61/00 , C07C209/68 , C07C209/88 , C07C211/03 , C07C213/02 , C07C213/08 , C07C217/08
Abstract: The invention relates to a method for producing racemic amines of formula (I ), in which R1 and R2 are not the same and R1, R2, R3 are alkyl-, cycloalkyl-, arylalkyl-, aryl-, heteroaryl rests and heterocyclic rests and R3 also represents hydrogen. Said rests can carry substituents selected from the gro up of alkyl, cycloalkyl, alkoxy, aryloxy, amino, alkylamino and dialkylamino. T he method is characterized in that the corresponding optically active amine (I) and the secondary alcohol of formula (II) and/or the asymmetrical ketone of formula (III) and the amine of the formula R3NH2 are simultaneously reacted in situ in the presence of hydrogen and a hydrogenation or dehydrogenation catalyst at an elevated temperature.
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公开(公告)号:AU4034699A
公开(公告)日:2000-06-05
申请号:AU4034699
申请日:1999-04-28
Applicant: BASF AG
Inventor: RIECHERS HARTMUT , SIMON JOACHIM , HOHN ARTHUR , KRAMER ANDREAS DR , FUNKE FRANK , SIEGEL WOLFGANG , NUBLING CHRISTOPH
IPC: B01J23/72 , B01J23/755 , B01J37/18 , C07B55/00 , C07B61/00 , C07C209/00 , C07C209/68 , C07C211/00 , C07C211/07 , C07C213/08 , C07C217/08
Abstract: Optically active amines are racemized by reaction of the optically active amine in the gas phase at elevated temperature in the presence of hydrogen and a hydrogenation or dehydrogenation catalyst.
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公开(公告)号:PT720655E
公开(公告)日:2000-04-28
申请号:PT94928365
申请日:1994-09-16
Applicant: BASF AG
Inventor: HAUER BERNHARD , LADNER WOLFGANG , PRESSLER UWE , BALKENHOHL FRIEDHELM , NUBLING CHRISTOPH
Abstract: PCT No. PCT/EP94/03102 Sec. 371 Date Mar. 11, 1996 Sec. 102(e) Date Mar. 11, 1996 PCT Filed Sep. 16, 1994 PCT Pub. No. WO95/08636 PCT Pub. Date Mar. 30, 1995A process for producing optically active primary and secondary amines from the corresponding racemates is characterised in that (a) a racemic amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bears a fluorine, nitrogen, oxygen or sulphur atom at the proximity of the carbonyl carbon atom; (b) the mixture of optically active amine and optically active acylated amine is separated so that an enantiomer of amine is produced; (c) if desired the other enantiomer of the amine is extracted from the acylated amine by amide cleavage.
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