公开(公告)号：DE59904879D1

公开(公告)日：2003-05-08

申请号：DE59904879

申请日：1999-11-30

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  KOTHRADE STEPHAN ,  KESSLER THOMAS ,  LANGE ARMIN ,  HOFMANN JUERGEN ,  REINHOLD ULRICH

IPC: A61J3/10 ,  A61K9/16 ,  A61K9/20 ,  B29C47/42

公开(公告)号：DE19911097A1

公开(公告)日：2000-09-14

申请号：DE19911097

申请日：1999-03-12

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  REINHOLD ULRICH ,  SIMON DIRK ,  LEHMANN STEPHAN

IPC: A01N25/08 ,  A01N25/10 ,  A61K8/73 ,  A61K8/86 ,  A61K9/20 ,  A61K9/22 ,  A61K31/192 ,  A61K31/565 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/40 ,  A61K47/48 ,  A61Q19/00 ,  C08B37/16 ,  A01N25/34 ,  A23L1/03 ,  A61K7/00 ,  A61K31/715 ,  B01J2/00

Abstract: The invention relates to a method for producing solid dosage forms containing at least one physiologically compatible polymer binding agent, at least one active agent and at least one cyclodextrin as components. According to the method, the components are mixed and plasticised at a temperature below 220 DEG C, without the addition of a solvent. The plastic mixture obtained is shaped into the dosage form. The invention also relates to the dosage forms obtained by said method.

公开(公告)号：DE19855440A1

公开(公告)日：2000-06-08

申请号：DE19855440

申请日：1998-12-01

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  KOTHRADE STEPHAN ,  KESLER THOMAS ,  LANGE ARMIN ,  HOFMANN JUERGEN ,  REINHOLD ULRICH

IPC: A61J3/10 ,  A61K9/16 ,  A61K9/20 ,  B29C47/42

Abstract: The invention relates to a method for producing solid forms of administration by means of melt extrusion. A polymer binder, at least one pharmaceutical active agent and optionally, other additives are mixed and the mixture is melted in an extruder and then extruded in the form of a continuous plastic product strand. The inventive method is characterised in that the extruder used is a planetary roller extruder (10) which preferably has one central spindle (13) and six planetary spindles (14).

公开(公告)号：CA2352874A1

公开(公告)日：2000-06-08

申请号：CA2352874

申请日：1999-11-30

Applicant: BASF AG

Inventor： REINHOLD ULRICH ,  HOFMANN JURGEN ,  KESSLER THOMAS ,  KOTHRADE STEPHAN ,  LANGE ARMIN ,  BERNDL GUNTHER

IPC: A61J3/10 ,  A61K9/16 ,  A61K9/20 ,  B29C47/42

Abstract: The invention relates to a method for producing solid forms of administratio n by means of melt extrusion. A polymer binder, at least one pharmaceutical active agent and optionally, other additives are mixed and the mixture is melted in an extruder and then extruded in the form of a continuous plastic product strand. The inventive method is characterised in that the extruder used is a planetary roller extruder (10) which preferably has one central spindle (13) and six planetary spindles (14).

公开(公告)号：AT235891T

公开(公告)日：2003-04-15

申请号：AT99966909

申请日：1999-11-30

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  KOTHRADE STEPHAN ,  KESSLER THOMAS ,  LANGE ARMIN ,  HOFMANN JUERGEN ,  REINHOLD ULRICH

IPC: A61J3/10 ,  A61K9/16 ,  A61K9/20 ,  B29C47/42

公开(公告)号：AT228828T

公开(公告)日：2002-12-15

申请号：AT00916925

申请日：2000-03-10

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  REINHOLD ULRICH ,  SIMON DIRK ,  LEHMANN STEPHAN

IPC: A01N25/08 ,  A01N25/10 ,  A61K8/73 ,  A61K8/86 ,  A61K9/20 ,  A61K9/22 ,  A61K31/192 ,  A61K31/565 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/40 ,  A61K47/48 ,  A61Q19/00