-
公开(公告)号：JP2000128775A
公开(公告)日：2000-05-09
申请号：JP29149199
申请日：1999-10-13
Applicant: BASF AG
Inventor： KOTHRADE STEPHAN DR , BREITENBACH JOERG DR , KRULL HARALD , KESSLER THOMAS , LANGE ARMIN , MAIER WERNER , REINHOLD ULRICH
IPC: A61K9/16 , A61K9/20 , A61K31/192
Abstract: PROBLEM TO BE SOLVED: To prepare solid preparations where a high molecular weight polymeric binder can be employed and the delayed release of an active ingredient is made possible by producing a plastic mixture of a specific polymeric binder, medicament active principle or the like under a specific condition and by molding the mixture so as to have a necessary dosage form. SOLUTION: The objective preparations are prepared by producing a plastic mixture of at least one kind selected from pharmaceutically acceptable polymeric binders having >75 K value (preferably homopolymer or a copolymer from vinylpyrrolidone) and at least one kind selected from medicament active principles, (e.g. ibuprofen or the like) and, optionally, a customary adjuvant under the condition of temperature (preferably
-
公开(公告)号：WO0032169A2
公开(公告)日：2000-06-08
申请号：PCT/EP9909309
申请日：1999-11-30
Applicant: BASF AG , BERNDL GUNTHER , KOTHRADE STEPHAN , KESSLER THOMAS , LANGE ARMIN , HOFMANN JUERGEN , REINHOLD ULRICH
Inventor： BERNDL GUNTHER , KOTHRADE STEPHAN , KESSLER THOMAS , LANGE ARMIN , HOFMANN JUERGEN , REINHOLD ULRICH
CPC classification number: B29C47/42 , A61J3/10 , A61J2200/20 , A61K9/1694 , A61K9/2095 , B29C47/0021
Abstract: The invention relates to a method for producing solid forms of administration by means of melt extrusion. A polymer binder, at least one pharmaceutical active agent and optionally, other additives are mixed and the mixture is melted in an extruder and then extruded in the form of a continuous plastic product strand. The inventive method is characterised in that the extruder used is a planetary roller extruder (10) which preferably has one central spindle (13) and six planetary spindles (14).
Abstract translation: 本发明涉及一种通过熔体挤出制备固体剂型的方法。 在这种情况下，混合的聚合物粘合剂，至少一种药物活性成分和任选的其它添加剂，将混合物熔化到挤出机中并挤出它然后在连续塑料产物链的形式。 使用本发明的方法的特征在于，作为挤出机具有一个行星辊挤出机（10），其优选地具有一个中心轴（13）和6个行星主轴（14）。
-
公开(公告)号：DE50000866D1
公开(公告)日：2003-01-16
申请号：DE50000866
申请日：2000-03-10
Applicant: BASF AG
Inventor： BERNDL GUNTHER , REINHOLD ULRICH , SIMON DIRK , LEHMANN STEPHAN
-
公开(公告)号：BR0008872A
公开(公告)日：2002-01-02
申请号：BR0008872
申请日：2000-03-10
Applicant: BASF AG
Inventor： BERNDL GUNTHER , REINHOLD ULRICH , SIMON DIRK , LEHMANN STEPHAN
-
公开(公告)号：DE19847618A1
公开(公告)日：2000-04-20
申请号：DE19847618
申请日：1998-10-15
Applicant: BASF AG
Inventor： KOTHRADE STEPHAN , BREITENBACH JOERG , KRULL HARALD , KESLER THOMAS , LANGE ARMIN , MAIER WERNER , REINHOLD ULRICH
IPC: A61K9/16 , A61K9/20 , A61K31/192 , A61K31/215
Abstract: Solid dosage forms are produced from a plastic mixture obtained by processing a polymeric binder with active agent under controlled conditions which reduce the initial K value (Fikentscher) of the binder of above 75 by less than 15. Production of solid dosage forms comprises: (a) preparing a plastic mixture from polymeric binder(s) with a K value (Fikentscher) above 75, active agent(s) and optionally conventional additives under temperature and shearing energy input conditions which reduce the molecular weight degradation of the binder by less than 15 K; and (b) forming the plastic mixture into the dosage forms.
-
Patent Agency Ranking
公开(公告)号：CA2367020C
公开(公告)日：2008-12-16
申请号：CA2367020
申请日：2000-03-10
Applicant: BASF AG
Inventor： LEHMANN STEPHAN , SIMON DIRK , BERNDL GUNTHER , REINHOLD ULRICH
IPC: A61K9/20 , A01N25/08 , A01N25/10 , A61K8/73 , A61K8/86 , A61K9/22 , A61K31/192 , A61K31/565 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/40 , A61K47/48 , A61Q19/00
Abstract: The invention relates to a method for producing solid dosage forms containin g at least one physiologically compatible polymer binding agent, at least one active agent and at least one cyclodextrin as components . According to the method, the components are mixed and plasticised at a temperature below 220 .degree.C, without the addition of a solvent. The plastic mixture obtained is shaped into the dosage form. The invention also relates to the dosage forms obtained by said method.
-
公开(公告)号：PT1158962E
公开(公告)日：2003-04-30
申请号：PT00916925
申请日：2000-03-10
Applicant: BASF AG
Inventor： REINHOLD ULRICH , BERNDL GUNTHER , SIMON DIRK , LEHMANN STEPHAN
-
公开(公告)号：DK1158962T3
公开(公告)日：2003-01-06
申请号：DK00916925
申请日：2000-03-10
Applicant: BASF AG
Inventor： BERNDL GUNTHER , LEHMANN STEPHAN , REINHOLD ULRICH , SIMON DIRK
-
公开(公告)号：CA2367020A1
公开(公告)日：2000-09-21
申请号：CA2367020
申请日：2000-03-10
Applicant: BASF AG
Inventor： SIMON DIRK , REINHOLD ULRICH , LEHMANN STEPHAN , BERNDL GUNTHER
IPC: A01N25/08 , A01N25/10 , A61K8/73 , A61K8/86 , A61K9/20 , A61K9/22 , A61K31/192 , A61K31/565 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/40 , A61K47/48 , A61Q19/00
Abstract: The invention relates to a method for producing solid dosage forms containin g at least one physiologically compatible polymer binding agent, at least one active agent and at least one cyclodextrin as components. According to the method, the components are mixed and plasticised at a temperature below 220 ~C, without the addition of a solvent. The plastic mixture obtained is shape d into the dosage form. The invention also relates to the dosage forms obtaine d by said method.
-
公开(公告)号：ES2187457T3
公开(公告)日：2003-06-16
申请号：ES00916925
申请日：2000-03-10
Applicant: BASF AG
Inventor： BERNDL GUNTHER , REINHOLD ULRICH , SIMON DIRK , LEHMANN STEPHAN
-
-
-
-
-
-
-
-
-
Search Results
16
records
(took 0.032 seconds)
