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    PRODUCTION OF SOLID PREPARATION
    2.
    发明专利
    PRODUCTION OF SOLID PREPARATION 失效

    公开(公告)号：JP2000128775A

    公开(公告)日：2000-05-09

    申请号：JP29149199

    申请日：1999-10-13

    Applicant: BASF AG

    Inventor： KOTHRADE STEPHAN DR ,  BREITENBACH JOERG DR ,  KRULL HARALD ,  KESSLER THOMAS ,  LANGE ARMIN ,  MAIER WERNER ,  REINHOLD ULRICH

    IPC: A61K9/16 ,  A61K9/20 ,  A61K31/192

    Abstract: PROBLEM TO BE SOLVED: To prepare solid preparations where a high molecular weight polymeric binder can be employed and the delayed release of an active ingredient is made possible by producing a plastic mixture of a specific polymeric binder, medicament active principle or the like under a specific condition and by molding the mixture so as to have a necessary dosage form. SOLUTION: The objective preparations are prepared by producing a plastic mixture of at least one kind selected from pharmaceutically acceptable polymeric binders having >75 K value (preferably homopolymer or a copolymer from vinylpyrrolidone) and at least one kind selected from medicament active principles, (e.g. ibuprofen or the like) and, optionally, a customary adjuvant under the condition of temperature (preferably

    9.
    发明专利
    未知

    公开(公告)号：BR9805747A

    公开(公告)日：1999-12-14

    申请号：BR9805747

    申请日：1998-12-30

    Applicant: BASF AG

    Inventor： LANGE ARMIN ,  MICKLITZ WOLFGANG ,  KARER RAINER ,  EVERTZ KASPAR ,  MIHAN SHAHRAM ,  FEINDT HANS-JACOB ,  HECKER MANFRED ,  BAUER PETER ,  ROSENDORFER PHILIPP

    IPC: C08K13/02 ,  C08F2/00 ,  C08F2/34 ,  C08F6/02 ,  C08F10/00 ,  C08F10/02 ,  C08F10/06 ,  C08F210/16 ,  C08F2/42

    Abstract: Continuous gas phase polymerization for producing ethylene homopolymers and -copolymers, comprises polymerizing ethylene or monoolefin from but-1-en, pent-1-en, 2-methylpentene, hex-1-en, hept-1-en and oct-1-en in the a polymerization reactor; and endowing a catalyst poison with boiling point higher than a circle gas pipeline, and molecular weight greater than 100 g/mol at a position after the reactor, but before the cooler and compressor. Continuous gas phase polymerization for producing ethylene homopolymers and -copolymers, comprises polymerizing ethylene and/or monoolefin from but-1-en, pent-1-en, 2-methylpentene, hex-1-en, hept-1-en or oct-1-en, in the polymerization zone of a gas phase polymerization reactor at 30-125[deg]C and 1-100 bar in the gaseous phase in a finely divided polymer bed, in the presence of a metallocene catalyst in carrier form polymer, where a reactor gas is lead into the circle gas pipeline for the removal of the polymerization heat; and endowing a catalyst poison with boiling point higher than circle gas pipeline and molecular weight greater than 100 g/mol at a position after the reactor but before the cooler and compressor, for preventing polymer linings, such that the productivity of the catalyst is not essentially affected in the reactor.

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