公开(公告)号：NO20020350A

公开(公告)日：2002-01-23

申请号：NO20020350

申请日：2002-01-23

Applicant: BASF AG

Inventor： HAUER BERNHARD ,  PLEISS JUERGEN ,  SCHWANEBERG ULRICH ,  SCHMITT JUTTA ,  FISCHER MARKUS ,  SCHMID ROLF ,  LI QING-SHAN

IPC: C12M1/40 ,  C12N1/21 ,  C12N9/02 ,  C12N15/09 ,  C12P7/02 ,  C12P7/04 ,  C12P7/22 ,  C12P7/42 ,  C12P7/64 ,  C12P17/10 ,  C12P17/16 ,  C12Q1/26 ,  C12R1/11 ,  C12R1/19 ,  C12N

CPC classification number: C12P7/6409 ,  C12N9/0071 ,  C12N9/0077 ,  C12P7/02 ,  C12P7/04 ,  C12P7/22 ,  C12P7/42 ,  C12P17/10 ,  C12P17/165 ,  C12Q1/26 ,  G01N2333/90245

公开(公告)号：CA2380186A1

公开(公告)日：2001-02-01

申请号：CA2380186

申请日：2000-07-27

Applicant: BASF AG

Inventor： PLEISS JUERGEN ,  HAUER BERNHARD ,  SCHWANEBERG ULRICH ,  SCHMITT JUTTA ,  FISCHER MARKUS ,  SCHMID ROLF ,  LI QING-SHAN ,  LUTZ-WAHL SABINE ,  APPEL DANIEL

IPC: C12N15/09 ,  C12M1/40 ,  C12N1/21 ,  C12N9/02 ,  C12N15/53 ,  C12P7/02 ,  C12P7/04 ,  C12P7/22 ,  C12P7/64 ,  C12P17/10 ,  C12P17/16 ,  C12Q1/26 ,  C12R1/19 ,  C12N15/70

Abstract: The invention relates to novel cytochrome P450 monooxygenases comprising a modified substrate specificity, to nucleotide sequences which code therefor, to expression constructs and vectors containing these sequences, and to microorganisms transformed therewith. The invention also relates to methods for microbiologically oxidizing different organic substrates, such as method s for producing indigo and indirubin.

公开(公告)号：CA2378615A1

公开(公告)日：2001-02-01

申请号：CA2378615

申请日：2000-07-27

Applicant: BASF AG

Inventor： SCHWANEBERG ULRICH ,  HAUER BERNHARD ,  PLEISS JUERGEN ,  SCHMITT JUTTA ,  FISCHER MARKUS ,  LI QING-SHAN ,  SCHMID ROLF

IPC: C12M1/40 ,  C12N1/21 ,  C12N9/02 ,  C12N15/09 ,  C12P7/02 ,  C12P7/04 ,  C12P7/22 ,  C12P7/42 ,  C12P7/64 ,  C12P17/10 ,  C12P17/16 ,  C12Q1/26 ,  C12R1/11 ,  C12R1/19 ,  C12N15/53 ,  C12N15/70

Abstract: The invention relates to modified cytochrome P450 monooxygenases comprising a modified substrate profile, to nucleic acid sequences that code therefor, to expression constructs and vectors, and to recombinant microorganisms which contain these vectors. The invention also relates to methods for microbiologically producing terminally or subterminally hydroxylated aliphat ic carboxylic acids.

公开(公告)号：DK1196603T3

公开(公告)日：2007-12-17

申请号：DK00951461

申请日：2000-07-27

Applicant: BASF AG

Inventor： HAUER BERNHARD ,  PLEISS JUERGEN ,  SCHWANEBERG ULRICH ,  SCHMITT JUTTA ,  FISCHER MARKUS ,  SCHMID ROLF ,  LI QING-SHAN

IPC: C12N1/21 ,  C12M1/40 ,  C12N9/02 ,  C12N15/53 ,  C12N15/09 ,  C12N15/70 ,  C12P7/02 ,  C12P7/04 ,  C12P7/22 ,  C12P7/42 ,  C12P7/64 ,  C12P17/10 ,  C12P17/16 ,  C12Q1/26 ,  C12R1/11 ,  C12R1/19

Abstract: The present invention relates to modified cytochrome P450 monooxygenases with an altered substrate profile, to nucleic acid sequences coding therefor, to expression constructs and vectors, to recombinant microorganisms which comprise these vectors, and to processes for the microbiological production of terminally or subterminally hydroxylated aliphatic carboxylic acids.

公开(公告)号：PT1196603E

公开(公告)日：2007-11-23

申请号：PT00951461

申请日：2000-07-27

Applicant: BASF AG

Inventor： HAUER BERNHARD ,  PLEISS JUERGEN ,  SCHWANEBERG ULRICH ,  SCHMITT JUTTA ,  FISCHER MARKUS ,  SCHMID ROLF ,  LI QING-SHAN

IPC: C12M1/40 ,  C12N1/21 ,  C12N15/53 ,  C12N9/02 ,  C12N15/09 ,  C12N15/70 ,  C12P7/02 ,  C12P7/04 ,  C12P7/22 ,  C12P7/42 ,  C12P7/64 ,  C12P17/10 ,  C12P17/16 ,  C12Q1/26 ,  C12R1/11 ,  C12R1/19

公开(公告)号：EE200200048A

公开(公告)日：2003-04-15

申请号：EEP200200048

申请日：2000-07-27

Applicant: BASF AG

Inventor： HAUER BERNHARD ,  PLEISS JUERGEN ,  SCHWANEBERG ULRICH ,  SCHMITT JUTTA ,  FISCHER MARKUS ,  SCHMID ROLF ,  LI QING-SHAN ,  LUTZ-WAHL SABINE ,  APPEL DANIEL

IPC: C12N15/09 ,  C12M1/40 ,  C12N1/21 ,  C12N9/02 ,  C12N15/53 ,  C12P7/02 ,  C12P7/04 ,  C12P7/22 ,  C12P7/64 ,  C12P17/10 ,  C12P17/16 ,  C12Q1/26 ,  C12R1/19 ,  C12N15/70

Abstract: The invention relates to novel cytochrome P450 monooxygenases comprising a modified substrate specificity, to nucleotide sequences which code therefor, to expression constructs and vectors containing these sequences, and to microorganisms transformed therewith. The invention also relates to methods for microbiologically oxidizing different organic substrates, such as methods for producing indigo and indirubin.

公开(公告)号：HU0202074A2

公开(公告)日：2002-09-28

申请号：HU0202074

申请日：2000-07-27

Applicant: BASF AG

Inventor： APPEL DANIEL ,  FISCHER MARKUS ,  HAUER BERNHARD ,  LI QING-SHAN ,  LUTZ-WAHL SABINE ,  PLEISS JUERGEN ,  SCHMID ROLF ,  SCHMITT JUTTA ,  SCHWANEBERG ULRICH

IPC: C12N15/09 ,  C12M1/40 ,  C12N1/21 ,  C12N9/02 ,  C12N15/53 ,  C12P7/02 ,  C12P7/04 ,  C12P7/22 ,  C12P7/64 ,  C12P17/10 ,  C12P17/16 ,  C12Q1/26 ,  C12R1/19

Abstract: The invention relates to novel cytochrome P450 monooxygenases comprising a modified substrate specificity, to nucleotide sequences which code therefor, to expression constructs and vectors containing these sequences, and to microorganisms transformed therewith. The invention also relates to methods for microbiologically oxidizing different organic substrates, such as methods for producing indigo and indirubin.

公开(公告)号：DE10051175A1

公开(公告)日：2002-05-02

申请号：DE10051175

申请日：2000-10-16

Applicant: BASF AG

Inventor： HAUER BERNHARD ,  SCHMID ROLF ,  MERKL RAINER ,  BLASCO FRANCESCA

IPC: C12N15/09 ,  C12M1/40 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/02 ,  C12N15/53 ,  C12P1/04 ,  C12P7/00 ,  C12R1/01 ,  C07H21/04 ,  C12N15/63 ,  C12N1/00 ,  C12P1/00

Abstract: The invention relates to novel cytochrome P450 monooxygenases consisting of thermophilic bacteria, especially the species Thermus sp., nucleotide sequences coding for the same, the recombinant production of said monooxygenases and the use thereof for the microbiological oxidation of organic compounds.

公开(公告)号：CA2378615C

公开(公告)日：2011-11-29

申请号：CA2378615

申请日：2000-07-27

Applicant: BASF AG

Inventor： HAUER BERNHARD ,  PLEISS JUERGEN ,  SCHWANEBERG ULRICH ,  SCHMITT JUTTA ,  FISCHER MARKUS ,  SCHMID ROLF ,  LI QING-SHAN

IPC: C12M1/40 ,  C12N15/53 ,  C12N1/21 ,  C12N9/02 ,  C12N15/09 ,  C12N15/70 ,  C12P7/02 ,  C12P7/04 ,  C12P7/22 ,  C12P7/42 ,  C12P7/64 ,  C12P17/10 ,  C12P17/16 ,  C12Q1/26 ,  C12R1/11 ,  C12R1/19

Abstract: The invention relates to modified cytochrome P450 monooxygenases comprising a modified substrate profile, to nucleic acid sequences that code therefor, to expression constructs and vectors, and to recombinant microorganisms which contain these vectors. The invention also relates to methods for microbiologically producing terminally or subterminally hydroxylated aliphatic carboxylic acids.

公开(公告)号：AT383575T

公开(公告)日：2008-01-15

申请号：AT02799414

申请日：2002-09-19

Applicant: BASF AG

Inventor： HAUER BERNHARD ,  MATUSCHEK MARKUS ,  SCHMID ROLF ,  BUTA CHRISTIANE ,  KAUFFMANN ISABELLE ,  LAEMMLE KATRIN ,  ZIPPER HUBERT

IPC: G01N33/24 ,  G01N33/50 ,  B01J20/281 ,  C12N15/09 ,  C12Q1/68 ,  G01N21/78 ,  G01N30/26 ,  G01N30/88

Abstract: The present invention relates to a method for preparing a normalized gene library from nucleic acid extracts of soil samples and to gene structures and vectors used in said method. The invention further relates to the use of the normalized gene library for the screening of genes coding for novel biocatalysts from the soil samples.