公开(公告)号：ES2073229T3

公开(公告)日：1995-08-01

申请号：ES92119226

申请日：1992-11-11

Applicant: BASF AG

Inventor： MUELLER WINFRIED DR ,  SPENGLER REINHARD DR ,  GRABOWSKI SVEN DR ,  SANNER AXEL DR

IPC: A61K9/20 ,  A61K9/22

公开(公告)号：DE58901404D1

公开(公告)日：1992-06-17

申请号：DE58901404

申请日：1989-08-10

Applicant: BASF AG

Inventor： HORN DIETER DR ,  KRUEGER GOETZ DR ,  SPENGLER REINHARD DR

IPC: A61K9/14 ,  A61K9/16 ,  A61K31/52 ,  A61K47/24 ,  A61K47/26 ,  A61P11/08

Abstract: A hydrophilic theophylline powder formulation consisting of (a) from 5 to 15% by weight of theophylline, (b) from 15 to 30% by weight of lechithin, (c) from 45 to 80% by weight of sugar, (d) from 0 to 5% by weight of a flow agent and (e) from 0 to 30% by weight of further additives, and a process for its preparation.

公开(公告)号：CS268177B2

公开(公告)日：1990-03-14

申请号：CS253287

申请日：1987-04-08

Applicant: BASF AG

Inventor： GOERTZ HANS-HELMUT DR ,  KLIMESCH ROGER G DR ,  LAEMMERHIRT KLAUS DR ,  LANG SIEGFRIED DR ,  SANNER AXEL DR ,  SPENGLER REINHARD DR

IPC: A61K47/32 ,  A61J3/06 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26 ,  A61K47/00

Abstract: Process for the preparation of solid pharmaceutical forms by mixing one or more pharmaceutical active compounds with one or more fusible, pharmacologically tolerated binders and, if required, other conventional pharmaceutical auxiliaries, at from 50 DEG to 180 DEG C., and subjecting the mixture to injection molding or extrusion and shaping, wherein the fusible binder used is a NVP polymer which contains not less than 20% by weight of NVP as copolymerized units, and, where they are present, all of whose comonomers contain nitrogen and/or oxygen.

公开(公告)号：CS8702532A2

公开(公告)日：1989-04-14

申请号：CS253287

申请日：1987-04-08

Applicant: BASF AG

Inventor： GOERTZ HANS-HELMUT DR ,  KLIMESCH ROGER G DR ,  LAEMMERHIRT KLAUS DR ,  LANG SIEGFRIED DR ,  SANNER AXEL DR ,  SPENGLER REINHARD DR

IPC: A61K47/32 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26 ,  A61K47/00

CPC classification number: A61K9/2095 ,  A61K9/2027 ,  B29K2105/0035

公开(公告)号：CS253287A2

公开(公告)日：1989-04-14

申请号：CS253287

申请日：1987-04-08

Applicant: BASF AG

Inventor： GOERTZ HANS-HELMUT DR ,  KLIMESCH ROGER G DR ,  LAEMMERHIRT KLAUS DR ,  LANG SIEGFRIED DR ,  SANNER AXEL DR ,  SPENGLER REINHARD DR

IPC: A61K47/32 ,  A61J3/06 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26 ,  A61K47/00

Abstract: Process for the preparation of solid pharmaceutical forms by mixing one or more pharmaceutical active compounds with one or more fusible, pharmacologically tolerated binders and, if required, other conventional pharmaceutical auxiliaries, at from 50 DEG to 180 DEG C., and subjecting the mixture to injection molding or extrusion and shaping, wherein the fusible binder used is a NVP polymer which contains not less than 20% by weight of NVP as copolymerized units, and, where they are present, all of whose comonomers contain nitrogen and/or oxygen.

公开(公告)号：DK0599064T3

公开(公告)日：1998-10-07

申请号：DK93117141

申请日：1993-10-22

Applicant: BASF AG

Inventor： HARTH KLAUS DR ,  HIBST HARTMUT DR ,  DEMBOWSKI JUERGEN DR ,  SPENGLER REINHARD DR ,  FLAIG ERNST DR

IPC: A61K9/32 ,  A61K9/22 ,  A61K9/28 ,  A61K9/50 ,  A61K9/52 ,  A61K47/34

公开(公告)号：DE4138513A1

公开(公告)日：1993-05-27

申请号：DE4138513

申请日：1991-11-23

Applicant: BASF AG

Inventor： MUELLER WINFRIED DR ,  SPENGLER REINHARD DR ,  GRABOWSKI SVEN DR ,  SANNER AXEL DR

IPC: A61K9/20 ,  A61K9/22

公开(公告)号：DE3869629D1

公开(公告)日：1992-05-07

申请号：DE3869629

申请日：1988-01-20

Applicant: BASF AG

Inventor： HORN DIETER DR ,  SPENGLER REINHARD DR

IPC: A61K9/14 ,  A61K9/10 ,  A61K9/107 ,  A61K9/16 ,  A61K47/00

Abstract: Pharmaceutical compsns. in aq. liq. or water-dispersible powder form contain a soln. of a water-insol. drug (I) in an edible oil or fat (II) in microdisperse form, together with an emulsifier (III) and a protective colloid (IV). The compsns. comprise (dry basis) 0.5-34% (I), 2.5-68% (II), 5-50% (III), 0.1-30% (IV), 0-70% plasticiser and 0-60% of one or more additives. The dia. of the oil-phase particles is less than 0.5 micron. (I) is a cpd. with a positive logarithmic octanol/H2O partition coefft., e.g. anipanil, propafenon, rilapin, nesapidil, verapamil, nonipamil, biperidin, kawain, ibuprofen, mefloquin, diazepam, carbamazepin, Na cromoglycate or amonafide.

公开(公告)号：DE3810343A1

公开(公告)日：1989-10-05

申请号：DE3810343

申请日：1988-03-26

Applicant: BASF AG

Inventor： GOERTZ HANS-HELMUT DR ,  KLIMESCH ROGER DR ,  LANG SIEGFRIED DR ,  ROSENBERG JOERG DR ,  SANNER AXEL DR ,  SPENGLER REINHARD DR ,  SCHLEMMER LOTHAR

IPC: A61K9/20 ,  A61K9/22

Abstract: Process for the production of solid pharmaceutical sustained release forms which contain as binder a polymer which dissolves or disperses in water and gastric or intestinal fluid, wherein the pharmaceutical agent, the polymeric binder and, where appropriate, the pharmaceutical ancillary substances are mixed below the glass transition temperature of the binder, this mixture is compressed, above the glass transition temperature of the binder but below the decomposition temperature of the agent, to pharmaceutical forms, and the form is removed from the mould at a temperature below the glass transition temperature of the binder, and where the type and amount of the binder and ancillary substance are chosen so that the release of agent is sustained for a period of 3 to 24 hours.

公开(公告)号：DE3702029A1

公开(公告)日：1988-08-04

申请号：DE3702029

申请日：1987-01-24

Applicant: BASF AG

Inventor： HORN DIETER DR ,  SPENGLER REINHARD DR

IPC: A61K9/14 ,  A61K9/10 ,  A61K9/107 ,  A61K9/16 ,  A61K47/00 ,  A61K9/00 ,  A61K31/275 ,  A61K31/425 ,  A61K31/135

Abstract: The pharmaceutical preparation contains an emulsifier, a protective colloid and an edible oil or fat in microdisperse form, a slightly water-soluble active agent being dissolved in the oil or fat.