公开(公告)号：NO313519B1

公开(公告)日：2002-10-14

申请号：NO992976

申请日：1999-06-17

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  JANSEN ROLF ,  KLING ANDREAS ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  HERGENROEDER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: C07D253/06 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  A61K31/53 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P13/08 ,  C07D237/14 ,  C07D237/16 ,  C07D241/18 ,  C07D253/07 ,  C07D253/075 ,  C07D253/10 ,  C07D403/12 ,  C07D491/04

Abstract: The present invention relates to carboxylic acid derivatives of the formula Iwhere the substituents have the meanings explained in the description, and to preparation and use as endothelin receptor antagonists.

公开(公告)号：PT994865E

公开(公告)日：2002-08-30

申请号：PT98938687

申请日：1998-07-03

Applicant: BASF AG

Inventor： UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  TREIBER HANS-JORG ,  WICKE KARSTEN ,  STARCK DOROTHEA ,  BLANK STEFAN ,  NEUMANN-SCHULTZ BARBARA ,  BRIS THEOPHILE-MARIE LE

IPC: A61K31/33 ,  A61K31/41 ,  A61K31/4196 ,  A61K31/454 ,  A61K31/506 ,  A61K31/53 ,  A61K31/551 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D249/08 ,  C07D249/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: Triazole compounds of the following formula:where Ar1, A, B and Ar2 have the meanings given in the description, possess a high affinity for the dopamine D3 receptor and can therefore be used for treating diseases which respond to dopamine D3 ligands.

公开(公告)号：CZ20012186A3

公开(公告)日：2002-07-17

申请号：CZ20012186

申请日：1999-12-09

Applicant: BASF AG

Inventor： AMBERG WILJHEM ,  JANSEN ROLF ,  KETTSCHAU GEORG ,  RIECHERS HARTMUT ,  BAUMANN ERNST ,  HERGENRODER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: C07D251/24 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/08 ,  A61P13/12 ,  A61P15/10 ,  A61P35/00 ,  A61P43/00 ,  C07C229/34 ,  C07C233/87 ,  C07C235/52 ,  C07D239/34 ,  C07D251/22 ,  C07D401/12 ,  C07D491/048 ,  C07D403/12 ,  A61P9/00 ,  A61P13/00

Abstract: The invention relates to carboxylic acid derivatives of formula (I), in which the substituents have the following meanings: R is tetrazol or a group (a); W and Z, can be identical or different and are nitrogen or methine, provided that if W and Z are methine, then Q is nitrogen; X is nitrogen or CR ; Y is nitrogen or CR ; Q is nitrogen or CR , provided that if Q is nitrogen then X is CR and Y is CR ; R and R are identical or different and are possibly substituted phenyl or naphthyl or phenyl or naphthyl which are linked in an ortho position via a direct bond, a methlyene, ethylene or ethenylene group, an oxygen or sulfur atom or a SO2-, NH- or N-alkyl group or possibly substituted C5-C6-cycloalkyl; R is a rest (b) or (c); and R is hydrogen, C1-C4-alkyl. The invention further relates to their preparation and their use as endothelin receptor antagonists. The invention also relates to compounds of formula (II) and a structural fragment of formula (d) in which the rests R , R , R , R and R have the meanings given in claim no. 1 and to their use as structural elements in an endothelin receptor antagonist.

公开(公告)号：DK0772603T3

公开(公告)日：2002-07-15

申请号：DK95926898

申请日：1995-07-14

Applicant: BASF AG

Inventor： UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  BIALOJAN SIEGFRIED ,  HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  MUNSCHAUER RAINER ,  WICKE KARSTEN ,  DRESCHER KARLA

IPC: C07D239/26 ,  A61K31/505 ,  A61K31/506 ,  A61P25/16 ,  A61P25/24 ,  A61P25/26 ,  C07D239/38 ,  C07D239/46 ,  C07D239/56 ,  C07D239/60 ,  C07D401/00 ,  C07D401/12

Abstract: The present invention relates to the use of pyrimidine compounds of the following formula:wherein R1, R2, R3, A, B and Ar have the meanings indicated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.

公开(公告)号：PL348920A1

公开(公告)日：2002-06-17

申请号：PL34892099

申请日：1999-12-24

Applicant: BASF AG

Inventor： STEINER GERD ,  SCHELLHAAS KURT ,  LUBISCH WILFRIED ,  HOLZENKAMP UTA ,  STARCK DOROTHEA ,  KNOPP MONIKA ,  SZABO LASZLO ,  EMLING FRANZ ,  GARCIA-LADONA FRANCISCO JAVIER ,  HOFMANN HANS-PETER ,  UNGER LILIANE

IPC: C07D495/04 ,  A61K31/505 ,  A61K31/519 ,  A61P9/10 ,  C07D495/14 ,  A61K31/495

Abstract: Use of pyrimidine derivatives of the formula Iwhere the substituents are as defined in the description, and of their physiologically tolerated salts for producing medicaments for the prophylaxis and treatment of cerebral ischemia and strokes.

公开(公告)号：PL348916A1

公开(公告)日：2002-06-17

申请号：PL34891699

申请日：1999-12-22

Applicant: BASF AG

Inventor： STEINER GERD ,  SCHELLHAAS KURT ,  LUBISCH WILFRIED ,  HOLZENKAMP UTA ,  STARCK DOROTHEA ,  SZABO LASZLO ,  EMLING FRANZ ,  GARCIA-LADONA FRANCISCO JAVIER ,  HOFMANN HANS-PETER ,  UNGER LILIANE

IPC: C07D275/06 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/502 ,  A61K31/517 ,  A61K31/519 ,  A61K31/522 ,  A61K31/55 ,  A61K31/551 ,  A61P9/10 ,  A61P25/28 ,  C07D401/12 ,  C07D417/12 ,  C07D471/04 ,  A61K31/428

Abstract: The invention relates to the utilisation of compounds of formula (I) wherein the substituents have the meanings given in the description. The invention also relates to the salts thereof comprising pharmacologically compatible acids for producing medicaments for the prophylaxis and therapy of cerebral ischaemia and strokes.

公开(公告)号：AT219063T

公开(公告)日：2002-06-15

申请号：AT95926898

申请日：1995-07-14

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  MUNSCHAUER RAINER ,  BIALOJAN SIEGFRIED ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN ,  DRESCHER KARLA

IPC: C07D239/26 ,  A61K31/505 ,  A61K31/506 ,  A61P25/16 ,  A61P25/24 ,  A61P25/26 ,  C07D239/38 ,  C07D239/46 ,  C07D239/56 ,  C07D239/60 ,  C07D401/00 ,  C07D401/12

Abstract: The present invention relates to the use of pyrimidine compounds of the following formula:wherein R1, R2, R3, A, B and Ar have the meanings indicated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.

公开(公告)号：TR200102025T2

公开(公告)日：2002-05-21

申请号：TR200102025

申请日：2000-01-12

Applicant: BASF AG

Inventor： STARCK DOROTHEA ,  TREIBER HANS-JOERG ,  UNGER LILIANE ,  NEUMANN-SCHULTZ BARBARA ,  BLUMBACH KAI ,  SCHOEBEL DIETMAR

IPC: A61K31/41 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/436 ,  A61K31/4439 ,  A61K31/4725 ,  A61K31/473 ,  A61K31/496 ,  C07D249/14 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/55 ,  A61P3/04 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P15/10 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/28 ,  A61P25/30 ,  A61P25/32 ,  A61P25/34 ,  A61P25/36 ,  A61P43/00 ,  C07D249/12 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D491/04 ,  C07D491/052 ,  A61P25/24 ,  C07D13/14

Abstract: Triazole compounds of the following formulawhere R1, R2, A and B have the meanings given in the description are described. The compounds according to the invention possess a high affinity for the dopamine D3 receptor and can therefore be used for treating diseases which respond to the influence of dopamine D3 ligands.

公开(公告)号：CZ20012485A3

公开(公告)日：2002-04-17

申请号：CZ20012485

申请日：1999-12-24

Applicant: BASF AG

Inventor： STEINER GERD ,  ACHELLHAAS KURT ,  LUBISCH WILFRIED ,  HOLZENKAMP UTA ,  STARCK DOROTHEA ,  KNOPP MONIKA ,  SZABO LASZLO ,  EMLING FRANZ ,  HOFMANN HANS-PETER ,  GARCIA-LADONA FRANCISCO JAVIER ,  UNGER LILIANE

IPC: C07D495/04 ,  A61K31/505 ,  A61K31/519 ,  A61P9/10 ,  C07D495/14 ,  A61K31/55

Abstract: Use of pyrimidine derivatives of the formula Iwhere the substituents are as defined in the description, and of their physiologically tolerated salts for producing medicaments for the prophylaxis and treatment of cerebral ischemia and strokes.

公开(公告)号：NO312243B1

公开(公告)日：2002-04-15

申请号：NO970473

申请日：1997-02-03

Applicant: BASF AG

Inventor： STEINER GERD ,  MUNSCHAUER RAINER ,  HOEGER THOMAS ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN

IPC: C07D401/06 ,  A61K31/40 ,  A61K31/415 ,  A61K31/47 ,  A61K31/505 ,  A61P25/18 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D513/04 ,  A61K31/506

Abstract: PCT No. PCT/EP95/02893 Sec. 371 Date Sep. 18, 1997 Sec. 102(e) Date Sep. 18, 1997 PCT Filed Jul. 21, 1995 PCT Pub. No. WO96/04272 PCT Pub. Date Feb. 15, 1996N-substitued 3-azabicyclo[3.2.0]heptane derivatives of formula (I) in which R1, R2, A, X, Y and Z have the meanings given in the description, their method of preparation and their use as pharmacological agents.