公开(公告)号：IN922DEN2015A

公开(公告)日：2015-06-12

申请号：IN922DEN2015

申请日：2015-02-05

Applicant: BASF SE ,  EVOLVA SA

Inventor： NAESBY MICHAEL ,  FOLLY CHRISTOPHE ,  NIELSEN CURT AIMÉ FRIIS ,  HATSCH ANAELLE ,  SCHWAB MARKUS ,  ZELDER OSKAR ,  HAEFNER STEFAN ,  SCHRÖDER HARTWIG ,  HOFF BIRGIT ,  MOLT ANDREA ,  DITRICH KLAUS ,  BREUER MICHAEL ,  HARTMANN HOLGER ,  KÖRBER KARSTEN

IPC: C12N1/21 ,  C12N1/15 ,  C12N1/16

Abstract: Microorganisms and processes for the recombinant manufacture of clavine type alkaloids such as cycloclavine festuclavine agroclavine chanoclavine and chanoclavine aldehyde as well as polypeptides polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine type alkaloids are provided.

公开(公告)号：DK3230435T5

公开(公告)日：2024-10-14

申请号：DK15817104

申请日：2015-12-09

Applicant: BASF SE

Inventor： HOFF BIRGIT ,  HAEFNER STEFAN ,  JEONG WEOL KYU ,  SCHOLTEN EDZARD

IPC: C12N1/08 ,  C12N1/06 ,  C12P25/00

公开(公告)号：MX2015002294A

公开(公告)日：2015-10-09

申请号：MX2015002294

申请日：2013-08-13

Applicant: BASF SE

Inventor： SCHRÖDER HARTWIG ,  HOFF BIRGIT ,  KÖRBER KARSTEN ,  HAEFNER STEFAN ,  ZELDER OSKAR ,  FOLLY CHRISTOPHE ,  NAESBY MICHAEL ,  NIELSEN CURT AIMÉ FRIIS ,  HATSCH ANAELLE ,  SCHWAB MARKUS ,  MOLT ANDREA ,  DITRICH KLAUS ,  BREUER MICHAEL ,  HARTMANN HOLGER

IPC: C12N1/21 ,  A61K31/48 ,  C07K14/195 ,  C07K14/37 ,  C07K16/00 ,  C12N1/15 ,  C12N1/16 ,  C12N15/31 ,  C12N15/52 ,  C12N15/80 ,  C12N15/81 ,  C12P1/00 ,  C12P17/10

Abstract: La invención, en principio, pertenece al campo de la fabricación recombinante de alcaloides de tipo clavina tales como cicloclavina, festuclavina, agroclavina, chanoclavina y aldehído de chanoclavina. Proporciona microorganismos y procesos para la fabricación de alcaloides de tipo clavina así como también polipéptidos, polinucleótidos y vectores que comprenden dichos polinucleótidos que se pueden aplicar en un método para la fabricación de alcaloides de tipo clavina.

公开(公告)号：CA2932046A1

公开(公告)日：2015-06-18

申请号：CA2932046

申请日：2014-12-04

Applicant: BASF SE

Inventor： HOFF BIRGIT ,  MOLT ANDREA ,  HAEFNER STEFAN ,  ZELDER OSKAR

IPC: C12P25/00

Abstract: The present invention relates to a method of producing riboflavin in a genetically modified organism of the genus Eremothecium, wherein said genetic modification is linked to the fatty acid uptake and/or beta-oxidation pathway of said organism, comprising growing said organisms in a culture medium and isolating riboflavin from the culture medium. The invention further relates to a method of providing a riboflavin accumulating organism belonging to the genus Eremothecium by genetically modifying said organism, to organisms obtained by such a method, as well as the use of such genetically modified organisms for increasing the accumulation of riboflavin.

公开(公告)号：CA2890416A1

公开(公告)日：2014-05-30

申请号：CA2890416

申请日：2013-11-13

Applicant: BASF SE

Inventor： ZELDER OSKAR ,  HOFF BIRGIT ,  SCHRODER HARTWIG ,  MOLT ANDREA ,  HARTMANN HOLGER ,  DITRICH KLAUS ,  BREUER MICHAEL ,  REINGRUBER RUDIGER ,  WEBER JAKOB

IPC: C12N15/11 ,  A01N37/00 ,  C07D307/77 ,  C12N15/63 ,  C12N15/67

Abstract: The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

公开(公告)号：EP2888351A4

公开(公告)日：2016-04-27

申请号：EP13831449

申请日：2013-08-13

Applicant: BASF SE ,  EVOLVA SA

Inventor： NAESBY MICHAEL ,  FOLLY CHRISTOPHE ,  NIELSEN CURT AIMÉ FRIIS ,  HATSCH ANAELLE ,  SCHWAB MARKUS ,  ZELDER OSKAR ,  HAEFNER STEFAN ,  SCHRÖDER HARTWIG ,  HOFF BIRGIT ,  MOLT ANDREA ,  DITRICH KLAUS ,  BREUER MICHAEL ,  HARTMANN HOLGER ,  KÖRBER KARSTEN

IPC: C12N15/52 ,  C12N9/00 ,  C12N9/10 ,  C12N9/88 ,  C12N9/90 ,  C12P17/18

CPC classification number: C12P17/12 ,  C07D209/90 ,  C07D487/06 ,  C07K16/40 ,  C12N9/0004 ,  C12N9/001 ,  C12N9/1007 ,  C12N9/1085 ,  C12N9/90 ,  C12N15/52 ,  C12P17/10 ,  C12P17/182 ,  C12Y205/01

Abstract: Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.

Abstract translation: 用于重组生产角鲨毒碱生物碱如环圈子，festuclavine，agroclavine，chanoclavine和chanoclavine醛的微生物和方法，以及多肽，多核苷酸和包含这样的多核苷酸的载体，其可以用于制造棒状的方法 提供生物碱。

公开(公告)号：EP2922954A4

公开(公告)日：2016-06-15

申请号：EP13857215

申请日：2013-11-13

Applicant: BASF SE

Inventor： ZELDER OSKAR ,  HOFF BIRGIT ,  SCHRÖDER HARTWIG ,  MOLT ANDREA ,  HARTMANN HOLGER ,  DITRICH KLAUS ,  BREUER MICHAEL ,  REINGRUBER RÜDIGER ,  WEBER JAKOB

IPC: C07K14/37 ,  C12R1/645

CPC classification number: C12P17/04 ,  A01N37/42 ,  A01N37/46 ,  A01N63/04 ,  C07D307/93 ,  C07K14/37 ,  C12N15/52 ,  C12N15/67 ,  C12N15/80

Abstract: The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

公开(公告)号：AU2013349330C1

公开(公告)日：2019-11-14

申请号：AU2013349330

申请日：2013-11-13

Applicant: BASF SE

Inventor： ZELDER OSKAR ,  HOFF BIRGIT ,  SCHRODER HARTWIG ,  MOLT ANDREA ,  HARTMANN HOLGER ,  DITRICH KLAUS ,  BREUER MICHAEL ,  REINGRUBER RUDIGER ,  WEBER JAKOB

IPC: C12N15/11 ,  A01N37/00 ,  C07D307/77 ,  C12N15/63 ,  C12N15/67

Abstract: The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

公开(公告)号：MX2015006385A

公开(公告)日：2015-12-08

申请号：MX2015006385

申请日：2013-11-13

Applicant: BASF SE

Inventor： SCHRÖDER HARTWIG ,  HOFF BIRGIT ,  ZELDER OSKAR ,  MOLT ANDREA ,  DITRICH KLAUS ,  BREUER MICHAEL ,  HARTMANN HOLGER ,  REINGRUBER RÜDIGER ,  WEBER JAKOB

IPC: C12N15/11 ,  A01N37/00 ,  C07D307/77 ,  C12N15/63 ,  C12N15/67

Abstract: La invención pertenece al campo de producción de productos naturales y, en particular, en el campo de la producción de cornexistina e hidroxicornexistina. Proporciona polinucleóticos que codifican polipéptidos implicados en la biosíntesis de cornexistiria e hidroxicornexistina, así como vectores y microorganismos recombinantes que comprenden tales polinucleótidos. También se proporcionan métodos para la producción de productos naturales, en particular métodos para la producción de cornexistina e hidroxicornexistina, usando tales polinucleótidos y polipéptidos codificados allí, así como vectores y microorganismos recombinantes que comprenden tales polinucleótidos y polipéptidos.

公开(公告)号：ZA201307315B

公开(公告)日：2014-12-23

申请号：ZA201307315

申请日：2013-10-01

Applicant: BASF SE

Inventor： SCHRODER HARTWIG ,  HOFF BIRGIT

IPC: A61K20060101

Abstract: The invention in principle pertains to the field of recombinant manufacture of alkaloids and, in particular, cycloclavine. It provides polynucleotides for the gene cluster of enzymes involved in the biosynthesis of cycloclavin as well as vectors and host cells comprising such polynucleotides. Also provided are polypeptides encoded by the said polynucleotides which can be applied in a method for the manufacture of cycloclavine also encompassed by the present invention.