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11.发明专利
公开(公告)号：CA2371431C
公开(公告)日：2010-09-21
申请号：CA2371431
申请日：2001-03-08
Applicant: BAXTER INT
Inventor： WOO LECON , SHANG SHERWIN , LING MICHAEL T K , DING YUAN-PANG SAMUEL , YANG TAHUA , SANDFORD CRAIG , CHANG TAO
IPC: B65D65/40 , C08L23/00 , A61J1/00 , A61J1/05 , A61J1/10 , A61J1/20 , B32B27/08 , B32B27/32 , B65D30/02 , B65D65/02 , C08J3/28 , C08J5/18 , C08L23/04 , C08L23/08 , C08L23/10 , C08L23/20 , C08L23/26 , C08L65/00
Abstract: The present invention provides a polymer blend for fabricating monolayer films or a layer within a multilayer film. The blend has a first component and a second component. The first component is selected from the group of: (1) an ethylene and ?-olefin copolymer having a density of less than about 0.915 g/cc, (2) lower alkyl acrylates, (3) lower alkyl substituted alkyl acrylates and (4) ionomers. The first component should be present in an amount from about 99 % to about 55 % by weight of the blend. The second component in an amount by weight of the blend from 45 % to about 1 % and consists of one or more polymers of the group: (1) propylene containing polymers, (2) polybutene polymers, (3)polymethylpentene polymers, (4) cyclic olefin containing polymers and (5) bridged polycyclic hydrocarbon containing polymers. When the blend is fabricated into a film it has a modulus of elasticity when measured in accordance with ASTM D882 of less than about 60,000 psi, an internal haze when measured in accordance with ASTM D1003 of less than about 25 %, an internal adhesion ranking of greater than about two, a sample creep at 120 °C under 27 psi loading of less than or equal to 150 % for a film having a thickness from about mils to about 15 mils, and the film being capable or being heat sealed into a container having seals wherein the seals remain intact when the container is autoclaved at 121 °C for one hour.
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公开(公告)号：AT460185T
公开(公告)日：2010-03-15
申请号：AT01912673
申请日：2001-01-26
Applicant: BAXTER INT
Inventor： WOO LECON , BOGGS DANIEL , STERNBERG SHMUEL , SANDFORD CRAIG , KHARE ATUL , BREILLATT JULIAN
Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a "carrying" mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposure to the radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid flow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation source (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven by a roller mechanism (38) in the direction of the fluid flow. As the fluid flows through the belt chamber (22), the flexible vanes (36) provide a squeegee-like mechanism to move the fluid through the belt chamber (22) in discrete packets (40) defined by a pair of vanes (36). As the packets of fluid move through the belt chamber, they are exposed to sterilizing radiation passing through the plate (32).
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公开(公告)号：AT454170T
公开(公告)日：2010-01-15
申请号：AT01905092
申请日：2001-01-26
Applicant: BAXTER INT
Inventor： WOO LECON , BOGGS DANIEL , STERNBERG SHMUEL , SANDFORD CRAIG , KHARE ATUL , BREILLATT JULIAN
Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous flow arrangement while exhibiting radiation dose uniformity and narrow residence time distribution of the fluid within the device. The device (10) comprises a radiation permeable cylindrical tube (12) having a concentric cylindrical rotor (14) disposed therein, thereby providing a thin gap (16) therebetween. A top plate (18) having a fluid outlet (26) and a bottom plate (20) having a fluid inlet (24) seal the cylindrical tube (12). The inlet (24) and outlet (26) are both in fluid communication with the thin gap (16). A rotor shaft (36) is diposed axially through the cylindrical rotor (14) and is connected to a motor (30). A pump provides fluid flow through the device (10). A radiation source provides sterilizing radiation to the fluid through the cylindrical tube (12). As the fluid flows, the motor (30) drives the rotor (14) to impart Taylor vortices to the fluid flow, which exchanges the fluid closer to the cylindrical tube (12) with the fluid closer to the rotor (14).
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公开(公告)号：ES2296784T3
公开(公告)日：2008-05-01
申请号：ES01959928
申请日：2001-03-08
Applicant: BAXTER INT
Inventor： WOO LECON , SHANG SHERWIN , LING MICHAEL T K , DING YUAN-PANG SAMUEL , YANG TAHUA , SANDFORD CRAIG
IPC: B65D65/40 , A61J1/00 , C08L23/04 , A61J1/05 , A61J1/10 , A61J1/20 , B32B27/08 , B32B27/32 , B65D30/02 , B65D65/02 , C08J3/28 , C08J5/18 , C08L23/00 , C08L23/08 , C08L23/10 , C08L23/20 , C08L23/26 , C08L65/00
Abstract: Película reticulada que comprende: una mezcla irradiada que comprende i. entre un 99% y un 55% en peso de la mezcla de un primer componente que es un copolímero de etileno y a-olefina con una densidad inferior a 0, 915 g/cc; ii. un segundo componente entre el 45% y el 1% en peso de la mezcla seleccionado de entre (1) polímeros que contienen propileno, (2) polímeros de polibuteno, (3) polímeros de polimetilpenteno, (4) polímeros que contienen olefinas cíclicas, (5) polímeros que contienen hidrocarburos policíclicos puente; caracterizada porque la película tiene un módulo de elasticidad, medido según la norma ASTM D882, inferior a 414 MPa (60.000 psi), una neblina interna, medida según la norma ASTM D1003, inferior al 25%, una adhesión interna superior a 2, una fluencia de muestra a 120ºC a una carga de 0, 2 MPa (27 psi) inferior o igual al 150% para una película con un grosor de entre 0, 13 mm (5 milipulgadas) y 0, 38 mm (15 milipulgadas), y pudiéndose termosellar la película formando un recipiente que tiene juntas estancas, donde las juntas estancas permanecen intactas cuando el recipiente se esteriliza en autoclave a 121ºC durante una hora.
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公开(公告)号：BRPI0415401A
公开(公告)日：2006-12-05
申请号：BRPI0415401
申请日：2004-10-04
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： SHANG SHERWIN , WOO LECON , YANG TAHUA , LING MICHAEL T K , SANDFORD CRAIG
Abstract: A monolayer film of a polymer blend of a first component selected from the group consisting of an ethylene containing polymer, the first component present in an amount by weight of the film from about 60% to about 1%, the first component having a first melting point temperature determined by DSC, a second component selected from the group consisting of propylene containing polymers and methyl pentene containing polymers, the second component being present in an amount by weight of the film from about 99% to about 40%, the second component having a second melting point temperature determined by DSC; and the film being capable of withstanding steam sterilization at a temperature from about 100° C. to about 130 ° C.
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Patent Agency Ranking
公开(公告)号：CA2538839A1
公开(公告)日：2005-05-19
申请号：CA2538839
申请日：2004-09-08
Applicant: BAXTER INT
Inventor： CHIM EDWIN , PAULEY ROBIN , SANDFORD CRAIG , PRISCO MICHAEL R , REITZ DOUGLAS W , PENNINGTON DAVID W , ARIAGNO SCOTT , YARDIMCI ATIF , SHETH MIHIR , SITES ARCH , CLARKE ROBERT A
Abstract: Flow-through systems for processing biological fluid are disclosed. The flow - through systems include a removal device in the flow path for removing unwanted compounds and agents. The removal device includes a removal media contained within a housing made of two separate portions sealed together. Th e housing is maintained in a substantially vertical disposition, thereby ensuring substantially uniform and complete exposure of the fluid to the med ia.
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公开(公告)号：CA2540028A1
公开(公告)日：2005-05-06
申请号：CA2540028
申请日：2004-10-04
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： YANG TAHUA , LING MICHAEL T K , SANDFORD CRAIG , WOO LECON , SHANG SHERWIN
Abstract: A monolayer film of a polymer blend of a first component selected from the group consisting of an ethylene containing polymer, the first component present in an amount by weight of the film from about 60% to about 1%, the first component having a first melting point temperature determined by DSC, a second component selected from the group consisting of propylene containing polymers and methyl pentene containing polymers, the second component being present in an amount by weight of the film from about 99% to about 40%, the second component having a second melting point temperature determined by DSC; and the film being capable of withstanding steam sterilization at a temperature from about 100° C. to about 130 ° C.
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公开(公告)号：BR0105090A
公开(公告)日：2002-02-13
申请号：BR0105090
申请日：2001-03-08
Applicant: BAXTER INT
Inventor： WOO LECON , SHANG SHERWIN , LING MICHAEL T K , DING YUAN-PANG SAMUEL , YANG TAHUA , SANDFORD CRAIG , CHANG TAO
IPC: B65D65/40 , A61J1/00 , A61J1/05 , A61J1/10 , A61J1/20 , B32B27/08 , B32B27/32 , B65D30/02 , B65D65/02 , C08J3/28 , C08J5/18 , C08L23/00 , C08L23/04 , C08L23/08 , C08L23/10 , C08L23/20 , C08L23/26 , C08L65/00
Abstract: The present invention provides a flowable materials container. The container has a first sidewall and a second sidewall sealed together along a peripheral seam to define a fluid chamber. At least one sidewall is a film having at least one layer of blend of a first component selected from the group of: (1) ethylene and alpha-olefin copolymers having a density of less than about 0.915 g/cc, (2) ethylene copolymerized with lower alkyl acrylates, (3) ethylene copolymerized with lower alkyl substituted alkyl acrylates and (4) ionomers, the first component being present in an amount from about 99% to about 55% by weight of the blend, a second component in an amount by weight of the blend from about 45% to about 1% and consists of one or more polymers of the group: (1) propylene containing polymers, (2) polybutene polymers, (3) polymethylpentene polymers, (4) cyclic olefin containing polymers and (5) bridged polycyclic hydrocarbon containing polymers; and the film has a modulus of elasticity when measured in accordance with ASTM D882 of less than about 60,000 psi, an internal haze when measured in accordance with ASTM D1003 of less than about 25%, an internal adhesion ranking of greater than about 2, a sample creep at 120° C. under 27 psi loading of less than or equal to 150% for a film having a thickness of from about 5 mils to about 15 mils, and the film can be heat sealed into a container having seals wherein the seals remain intact when the container is autoclaved at 121° C. for one hour.
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19.发明专利
公开(公告)号：CA2371431A1
公开(公告)日：2001-09-27
申请号：CA2371431
申请日：2001-03-08
Applicant: BAXTER INT
Inventor： WOO LECON , LING MICHAEL T K , CHANG TAO , SHANG SHERWIN , SANDFORD CRAIG , DING YUAN-PANG SAMUEL , YANG TAHUA
IPC: B65D65/40 , A61J1/00 , A61J1/05 , A61J1/10 , A61J1/20 , B32B27/08 , B32B27/32 , B65D30/02 , B65D65/02 , C08J3/28 , C08J5/18 , C08L23/00 , C08L23/04 , C08L23/08 , C08L23/10 , C08L23/20 , C08L23/26 , C08L65/00
Abstract: The present invention provides a polymer blend for fabricating monolayer fil ms or a layer within a multilayer film. The blend has a first component and a second component. The first component is selected from the group of: (1) an ethylene and ?-olefin copolymer having a density of less than about 0.915 g/cc, (2) lower alkyl acrylates, (3) lower alkyl substituted alkyl acrylates and (4) ionomers. The first component should be present in an amount from about 99 % to about 55 % by weight of the blend. The second component in an amount by weight of the blend from 45 % to about 1 % and consists of one or more polymers of the group: (1) propylene containing polymers, (2) polybuten e polymers, (3)polymethylpentene polymers, (4) cyclic olefin containing polyme rs and (5) bridged polycyclic hydrocarbon containing polymers. When the blend i s fabricated into a film it has a modulus of elasticity when measured in accordance with ASTM D882 of less than about 60,000 psi, an internal haze wh en measured in accordance with ASTM D1003 of less than about 25 %, an internal adhesion ranking of greater than about two, a sample creep at 120 ~C under 2 7 psi loading of less than or equal to 150 % for a film having a thickness fro m about 5 mils to about 15 mils, and the film being capable or being heat seal ed into acontainer having seals wherein the seals remain intact when the container is autoclaved at 121 ~C for one hour.
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公开(公告)号：AU5086401A
公开(公告)日：2001-09-24
申请号：AU5086401
申请日：2001-03-16
Applicant: BAXTER INT
Inventor： WOO LECON , SHANG SHERWIN , LING MICHAEL T K , DING YUAN-PANG SAMUEL , YANG TAHUA , SANDFORD CRAIG
IPC: B65D65/40 , A61J1/00 , A61J1/05 , A61J1/10 , A61J1/20 , B32B27/08 , B32B27/32 , B65D30/02 , B65D65/02 , C08J3/28 , C08J5/18 , C08L23/00 , C08L23/04 , C08L23/08 , C08L23/10 , C08L23/20 , C08L23/26 , C08L65/00 , B32B27/00
Abstract: The present invention provides a flowable materials container. The container has a first sidewall and a second sidewall sealed together along a peripheral seam to define a fluid chamber. At least one sidewall is a film having at least one layer of blend of a first component selected from the group of: (1) ethylene and alpha-olefin copolymers having a density of less than about 0.915 g/cc, (2) ethylene copolymerized with lower alkyl acrylates, (3) ethylene copolymerized with lower alkyl substituted alkyl acrylates and (4) ionomers, the first component being present in an amount from about 99% to about 55% by weight of the blend, a second component in an amount by weight of the blend from about 45% to about 1% and consists of one or more polymers of the group: (1) propylene containing polymers, (2) polybutene polymers, (3) polymethylpentene polymers, (4) cyclic olefin containing polymers and (5) bridged polycyclic hydrocarbon containing polymers; and the film has a modulus of elasticity when measured in accordance with ASTM D882 of less than about 60,000 psi, an internal haze when measured in accordance with ASTM D1003 of less than about 25%, an internal adhesion ranking of greater than about 2, a sample creep at 120° C. under 27 psi loading of less than or equal to 150% for a film having a thickness of from about 5 mils to about 15 mils, and the film can be heat sealed into a container having seals wherein the seals remain intact when the container is autoclaved at 121° C. for one hour.
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