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公开(公告)号：DE3939858C2
公开(公告)日：1995-11-16
申请号：DE3939858
申请日：1989-12-01
Applicant: BIO RAD LABORATORIES
Inventor： BURD SAMUEL
IPC: G01N27/447 , B01D57/02
Abstract: A capillary tube for use in high performance capillary electrophoresis is enclosed in a cartridge of generally planar configuration, formed by two flat plates joined together along raised edges to define a shallow enclosed chamber to retain the looped capillary tube, the plates having aligned windows between which a segment of the capillary tube passes, thereby forming a light path for zone detection. The termini of the capillary are embedded in fittings extending from the exterior of the cartridge, which mate with complementary fittings on inlet and outlet blocks which contain buffer reservoirs with controlled hydrostatic heads. The inlet block is specially equipped with ducts and fittings to permit filling of the capillary, injection of the sample into the capillary, changing of the solution in the buffer reservoir, and flushing out of the entire block without disconnecting the block from the capillary cartridge. By securing the cartridge containing the capillary tube into its holder, the capillary tube is correctly aligned in the detector light path.
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公开(公告)号：GB2226572B
公开(公告)日：1993-08-11
申请号：GB8926264
申请日：1989-11-21
Applicant: BIO RAD LABORATORIES
Inventor： BURD SAMUEL
IPC: G01N27/447
Abstract: A capillary tube for use in high performance capillary electrophoresis is enclosed in a cartridge of generally planar configuration, formed by two flat plates joined together along raised edges to define a shallow enclosed chamber to retain the looped capillary tube, the plates having aligned windows between which a segment of the capillary tube passes, thereby forming a light path for zone detection. The termini of the capillary are embedded in fittings extending from the exterior of the cartridge, which mate with complementary fittings on inlet and outlet blocks which contain buffer reservoirs with controlled hydrostatic heads. The inlet block is specially equipped with ducts and fittings to permit filling of the capillary, injection of the sample into the capillary, changing of the solution in the buffer reservoir, and flushing out of the entire block without disconnecting the block from the capillary cartridge. By securing the cartridge containing the capillary tube into its holder, the capillary tube is correctly aligned in the detector light path.
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公开(公告)号：GB2257160B
公开(公告)日：1993-07-14
申请号：GB9214064
申请日：1992-07-01
Applicant: BIO RAD LABORATORIES
Inventor： BURD SAMUEL
IPC: G01N27/447
Abstract: A capillary tube for use in high performance capillary electrophoresis is enclosed in a cartridge of generally planar configuration, formed by two flat plates joined together along raised edges to define a shallow enclosed chamber to retain the looped capillary tube, the plates having aligned windows between which a segment of the capillary tube passes, thereby forming a light path for zone detection. The termini of the capillary are embedded in fittings extending from the exterior of the cartridge, which mate with complementary fittings on inlet and outlet blocks which contain buffer reservoirs with controlled hydrostatic heads. The inlet block is specially equipped with ducts and fittings to permit filling of the capillary, injection of the sample into the capillary, changing of the solution in the buffer reservoir, and flushing out of the entire block without disconnecting the block from the capillary cartridge. By securing the cartridge containing the capillary tube into its holder, the capillary tube is correctly aligned in the detector light path.
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公开(公告)号：DE3939858A1
公开(公告)日：1990-06-07
申请号：DE3939858
申请日：1989-12-01
Applicant: BIO RAD LABORATORIES
Inventor： BURD SAMUEL
IPC: G01N27/447
Abstract: A capillary tube for use in high performance capillary electrophoresis is enclosed in a cartridge of generally planar configuration, formed by two flat plates joined together along raised edges to define a shallow enclosed chamber to retain the looped capillary tube, the plates having aligned windows between which a segment of the capillary tube passes, thereby forming a light path for zone detection. The termini of the capillary are embedded in fittings extending from the exterior of the cartridge, which mate with complementary fittings on inlet and outlet blocks which contain buffer reservoirs with controlled hydrostatic heads. The inlet block is specially equipped with ducts and fittings to permit filling of the capillary, injection of the sample into the capillary, changing of the solution in the buffer reservoir, and flushing out of the entire block without disconnecting the block from the capillary cartridge. By securing the cartridge containing the capillary tube into its holder, the capillary tube is correctly aligned in the detector light path.
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公开(公告)号：IT8948616D0
公开(公告)日：1989-11-30
申请号：IT4861689
申请日：1989-11-30
Applicant: BIO RAD LABORATORIES
Inventor： BURD SAMUEL
IPC: G01N27/447 , C25B
Abstract: A capillary tube for use in high performance capillary electrophoresis is enclosed in a cartridge of generally planar configuration, formed by two flat plates joined together along raised edges to define a shallow enclosed chamber to retain the looped capillary tube, the plates having aligned windows between which a segment of the capillary tube passes, thereby forming a light path for zone detection. The termini of the capillary are embedded in fittings extending from the exterior of the cartridge, which mate with complementary fittings on inlet and outlet blocks which contain buffer reservoirs with controlled hydrostatic heads. The inlet block is specially equipped with ducts and fittings to permit filling of the capillary, injection of the sample into the capillary, changing of the solution in the buffer reservoir, and flushing out of the entire block without disconnecting the block from the capillary cartridge. By securing the cartridge containing the capillary tube into its holder, the capillary tube is correctly aligned in the detector light path.
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Patent Agency Ranking
公开(公告)号：GB2143946B
公开(公告)日：1986-12-10
申请号：GB8412734
申请日：1984-05-18
Applicant: BIO RAD LABORATORIES
Inventor： FERNWOOD GEORGE , BURD SAMUEL
Abstract: A biochemical test plate assembly is disclosed for use in both filter assays and fluid retention applications. The assembly comprises an upper template with a plurality of discrete apertures, a continuous microporous film underlying the upper template, a gasket underlying the microporous film with apertures matching those of the upper template, a lower template underlying the gasket with a similar array of apertures matching those of both the upper template and the gasket, each aperture terminating at its upper end in a flat boss, and a base plate having a central recess to define an enclosed chamber when the base plate and lower template are in contact, the base plate being designed to form an air-tight seal between it and the lower template.
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公开(公告)号：DE3425762A1
公开(公告)日：1985-02-14
申请号：DE3425762
申请日：1984-07-12
Applicant: BIO RAD LABORATORIES
Inventor： FERNWOOD GEORGE , BURD SAMUEL
IPC: G01N33/48 , B01D61/18 , B01L3/00 , C12M1/12 , C12M1/20 , G01N33/53 , G01N33/543 , G01N31/20 , G01N33/54
Abstract: A biochemical test plate assembly is disclosed for use in both filter assays and fluid retention applications. The assembly comprises an upper template with a plurality of discrete apertures, a continuous microporous film underlying the upper template, a gasket underlying the microporous film with apertures matching those of the upper template, a lower template underlying the gasket with a similar array of apertures matching those of both the upper template and the gasket, each aperture terminating at its upper end in a flat boss, and a base plate having a central recess to define an enclosed chamber when the base plate and lower template are in contact, the base plate being designed to form an air-tight seal between it and the lower template.
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公开(公告)号：CA3075139C
公开(公告)日：2022-04-12
申请号：CA3075139
申请日：2009-09-23
Applicant: BIO RAD LABORATORIES
Inventor： COLSTON BILLY WAYNE , HINDSON BENJAMIN JOSEPH , NESS KEVIN DEAN , MASQUELIER DONALD ARTHUR , MILANOVICH FRED PAUL , MODLIN DOUGLAS N , RIOT VINCENT , BURD SAMUEL , MAKAREWICZ ANTHONY JOSEPH , BELGRADER PHILLIP
Abstract: A method of performing a droplet-based assay involving obtaining droplets encapsulated by an immiscible liquid and packed closely together in a monolayer. The method also involves performing a reaction in the droplets while packed closely together in the monolayer, and collecting data related to an analyte from a plurality of the droplets while the droplets remain closely packed together in the monolayer.
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公开(公告)号：GB2502409B
公开(公告)日：2014-03-12
申请号：GB201303939
申请日：2009-09-23
Applicant: BIO RAD LABORATORIES
Inventor： COLSTON BILLY WAYNE JR , HINDSON BENJAMIN JOSEPH , NESS KEVIN DEAN , MASQUELIER DONALD ARTHUR , MILANOVICH FRED PAUL , MODLIN DOUGLAS N , RIOT VINCENT , BURD SAMUEL , MARKAREWICZ ANTHONY JOSEPH
Abstract: A system for sample analysis, comprising:at least one droplet generator that forms a plurality of emulsions including droplets of partitioned samples, the samples being prepared as reaction mixtures for amplification of a nucleic acid target;a plate defining an array of cavities to hold the emulsions;a heating and cooling device to heat the emulsions disposed in the cavities to induce nucleic acid amplification in droplets of the emulsions;a detection assembly to detect signals from intact droplets of the emulsions;a fluid transfer device including an autosampler configured to transfer droplets from each of the cavities to a detection site of the detection assembly; anda controller in communication with the detection assembly and programmed to estimate a presence, if any, of the nucleic acid target in the samples based on signals detected from the intact droplets.
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公开(公告)号：GB2504241A
公开(公告)日：2014-01-22
申请号：GB201319376
申请日：2009-09-23
Applicant: BIO RAD LABORATORIES
Inventor： COLSTON BILLY WAYNE JR , HINDSON BENJAMIN JOSEPH , NESS KEVIN DEAN , MASQUELIER DONALD ARTHUR , MILANOVICH FRED PAUL , MODLIN DOUGLAS N , RIOT VINCENT , BURD SAMUEL , MARKAREWICZ ANTHONY JOSEPH
Abstract: A droplet based assay comprising an emulsion including droplets packed in a three-dimensional arrangement, the droplets are reacted, such as thermocycled in this packaged form and then passed serially through a detector region to analyse individual droplets. Other inventions relate to formation of a plurality of emsulsions together and collecting data from individual droplets, these assays may be specific methods of nucleic acid amplification which include thermocycling and that may be conducted from a multiwall plate array of samples, a droplet transporter may pick-up droplets from a sample holder .
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