公开(公告)号：AU2019200070A1

公开(公告)日：2019-01-31

申请号：AU2019200070

申请日：2019-01-07

Applicant: BIO RAD LABORATORIES

Inventor： WALKER ROGER ,  JARDIN BENEDICTE

IPC: G01N33/53 ,  C07K16/18 ,  G01N33/72

Abstract: Hemoglobin, its variants, and glycated forms of each are determined individually in a multiplex assay that permits correction of the measured level of HbAic to account for 5 glycated variants and other factors related to the inclusion of the variants in the sample. New antibodies that are particularly well adapted to the multiplex assay are also provided. 10971153_1 (GHMatters) P90472.AU.2 .. .. .. . .. .. . C. . . .. . . . .. . . . .. . . . . ..w. . . .

公开(公告)号：CA2781255A1

公开(公告)日：2011-05-26

申请号：CA2781255

申请日：2010-11-09

Applicant: BIO RAD LABORATORIES

Inventor： WALKER ROGER ,  JARDIN BENEDICTE

IPC: G01N33/72 ,  C07K16/18

Abstract: Hemoglobin, its variants, and glycated forms of each are determined individually in a multiplex assay that permits correction of the measured level of HbAI c to account for glycated variants and other factors related to the inclusion of the variants in the sample. New antibodies that are particularly well adapted to the multiplex assay are also provided.

公开(公告)号：ES2711402T3

公开(公告)日：2019-05-03

申请号：ES14789058

申请日：2014-04-25

Applicant: BIO RAD LABORATORIES

Inventor： KAUL RAVI ,  ZHENG WEIMING ,  WALKER ROGER

IPC: G01N33/53 ,  G01N33/543 ,  G01N33/576

Abstract: Un kit que comprende: (a) un primer receptáculo que comprende: (i) perlas que se conjugan con antígeno de superficie de Hepatitis B (HBsAg) de humano y marcador detectable (i), (ii) perlas que se conjugan con antígeno de núcleo de Hepatitis B (HBcAg) de humano y marcador detectable (ii), y (iii) perlas que se conjugan con un anticuerpo específico para IgM (anti-IgM) de humano y marcador detectable (iii); (b) un segundo receptáculo que comprende (i) HBsAg biotinilado, y (ii) HBcAg biotinilado; y (c) un tercer receptáculo que comprende estreptavidina que se conjuga con un marcador detectable (iv).

公开(公告)号：AU2017200733B2

公开(公告)日：2018-10-11

申请号：AU2017200733

申请日：2017-02-03

Applicant: BIO RAD LABORATORIES

Inventor： WALKER ROGER ,  JARDIN BENEDICTE

IPC: G01N33/53 ,  C07K16/18 ,  G01N33/72

Abstract: Hemoglobin, its variants, and glycated forms of each are determined individually in a multiplex assay that permits correction of the measured level of HbAi to account for 5 glycated variants and other factors related to the inclusion of the variants in the sample. New antibodies that are particularly well adapted to the multiplex assay are also provided. 8670427_1 (GHMatters) P90472.AU.1

公开(公告)号：AU2011308657B2

公开(公告)日：2014-12-18

申请号：AU2011308657

申请日：2011-09-30

Applicant: BIO RAD LABORATORIES

Inventor： LU YABIN ,  WALKER ROGER

IPC: G01N33/48

Abstract: Methods, systems, and apparatus for accurately determining a proportion (ratio) of two analytes is provided, as well as provide a concentration of a first analyte from a determined concentration of a second analyte and from a proportion of the analytes to each other. In one aspect, a surface model (called a dose surface herein) relating the concentrations of the two analytes to the proportion can be used to obtain accurate values for one of the variables (e.g. a concentration or the proportion) when the other two variables have previously been obtained. The dose surface can be a three-dimensional surface and be non-linear. The dose surface model can include multiple regression functions. For example, measured responses can be individually converted to concentrations using two dose-response curves, and the concentrations can be input to a dose surface function to obtain the proportion.

公开(公告)号：AU2010322233A1

公开(公告)日：2012-06-21

申请号：AU2010322233

申请日：2010-11-09

Applicant: BIO RAD LABORATORIES

Inventor： WALKER ROGER ,  JARDIN BENEDICTE

IPC: G01N33/53 ,  C07K16/18 ,  G01N33/72

Abstract: Hemoglobin, its variants, and glycated forms of each are determined individually in a multiplex assay that permits correction of the measured level of HbAI c to account for glycated variants and other factors related to the inclusion of the variants in the sample. New antibodies that are particularly well adapted to the multiplex assay are also provided.

公开(公告)号：AU2017272223B2

公开(公告)日：2019-05-09

申请号：AU2017272223

申请日：2017-12-06

Applicant: BIO RAD LABORATORIES

Inventor： WALKER ROGER ,  LU YABIN ,  DESAI URVEE ,  SHAN DAMING

IPC: G01N33/53 ,  G01N33/543

Abstract: The present invention provides a method for determining whether a subject is suffering from celiac disease by contacting a sample of bodily fluid from the subject, with an antigen formed from a hexamer of a gliadin fusion protein immobilized on a solid support. The gliadin fusion protein of the antigen includes a recombinant deamidated gliadin linked to a tag such as Glutathione-S transferase (GST) protein. The antigen is prepared by immobilizing the gliadin fusion protein on the solid support. The antigen can further include tissue Transglutaminase (tTG) cross-linked to the gliadin fusion protein. When tTG is present, the tTG and recombinant deamidated gliadin are mixed together prior to immobilization to the solid phase. 9765390_1 (GHMatters) P97180.AU.1

公开(公告)号：ES2665958T3

公开(公告)日：2018-04-30

申请号：ES16155015

申请日：2010-11-09

Applicant: BIO RAD LABORATORIES

Inventor： WALKER ROGER ,  JARDIN BENEDICTE

IPC: G01N33/531 ,  C07K16/18 ,  G01N33/577 ,  G01N33/58 ,  G01N33/72

Abstract: Un anticuerpo monoclonal que se une selectivamente a la variante de hemoglobina HbC y la HbC glicada, en el que el anticuerpo se une a un epítopo mínimo de HbC 4TPKEKSAVT12

公开(公告)号：AU2017272223A1

公开(公告)日：2018-01-04

申请号：AU2017272223

申请日：2017-12-06

Applicant: BIO-RAD LABORATORIES INC

Inventor： WALKER ROGER ,  LU YABIN ,  DESAI URVEE ,  SHAN DAMING

IPC: G01N33/53 ,  G01N33/543

Abstract: The present invention provides a method for determining whether a subject is suffering from celiac disease by contacting a sample of bodily fluid from the subject, with an antigen formed from a hexamer of a gliadin fusion protein immobilized on a solid support. The gliadin fusion protein of the antigen includes a recombinant deamidated gliadin linked to a tag such as Glutathione-S transferase (GST) protein. The antigen is prepared by immobilizing the gliadin fusion protein on the solid support. The antigen can further include tissue Transglutaminase (tTG) cross-linked to the gliadin fusion protein. When tTG is present, the tTG and recombinant deamidated gliadin are mixed together prior to immobilization to the solid phase. 9765390_1 (GHMatters) P97180.AU.1

公开(公告)号：AU2012348122B2

公开(公告)日：2017-09-14

申请号：AU2012348122

申请日：2012-12-03

Applicant: BIO RAD LABORATORIES

Inventor： WALKER ROGER ,  LU YABIN ,  DESAI URVEE ,  SHAN DAMING

IPC: G01N33/53 ,  G01N33/543

Abstract: The present invention provides a method for determining whether a subject is suffering from celiac disease by contacting a sample of bodily fluid from the subject, with an antigen formed from a hexamer of a gliadin fusion protein immobilized on a solid support. The gliadin fusion protein of the antigen includes a recombinant deamidated gliadin linked to a tag such as Glutathione-S transferase (GST) protein. The antigen is prepared by immobilizing the gliadin fusion protein on the solid support. The antigen can further include tissue Transglutaminase (tTG) cross-linked to the gliadin fusion protein. When tTG is present, the tTG and recombinant deamidated gliadin are mixed together prior to immobilization to the solid phase.