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公开(公告)号：EP1766350A4
公开(公告)日：2010-01-20
申请号：EP05857501
申请日：2005-06-30
Applicant: CHEMIMAGE CORP
Inventor： NELSON MATTHEW P , TREADO PATRICK , ATTANUCCI JASON
CPC classification number: G01J3/44 , G01N15/1475 , G01N21/3563 , G01N21/3577 , G01N21/359 , G01N21/65 , G01N2015/1497
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12.发明申请SYSTEM AND METHOD FOR SUPER RESOLUTION OF A SAMPLE IN A FIBER ARRAY SPECTRAL TRANSLATOR SYSTEM 审中-公开在光纤阵列传输系统中超分辨率的系统和方法
公开(公告)号：WO2007117764A3
公开(公告)日：2008-10-02
申请号：PCT/US2007062080
申请日：2007-02-13
Applicant: CHEMIMAGE CORP , NELSON MATTHEW P , NEISS JASON H , TREADO PATRICK J
Inventor： NELSON MATTHEW P , NEISS JASON H , TREADO PATRICK J
CPC classification number: G01J3/02 , G01J3/0218 , G01J3/0221 , G01J3/28 , G01J3/2803 , G01J3/2823 , G01N21/255 , G01N21/274 , G01N2201/0833
Abstract: The disclosure relates generally to methods and apparatus for obtaining a super resolution image of a sample using a fiber array spectral translator system. In one embodiment includes collecting photons from a sample at a first end of a fiber array spectral translator; delivering the photons from a second end of the fiber array spectral translator into a multiple detector rows of a photon detector; interpolating between the multiple detector rows to thereby form interpolated rows; and arranging an output of the multiple detector rows and the interpolated rows so as to obtain a super resolution image of the sample.
Abstract translation: 本公开一般涉及使用光纤阵列频谱转换器系统获得样本的超分辨率图像的方法和装置。 在一个实施例中，包括在光纤阵列光谱转换器的第一端收集来自样品的光子; 将光子从光纤阵列频谱转换器的第二端传送到光子检测器的多个检测器行中; 在多个检测器行之间内插，从而形成内插行; 并且布置多个检测器行和内插行的输出，以便获得样本的超分辨率图像。
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13.发明申请METHOD AND APPARATUS FOR COMPACT SPECTROMETER WITH FIBER ARRAY SPECTRAL TRANSLATOR 审中-公开具有光纤阵列光谱转换器的紧凑光谱仪的方法和装置
公开(公告)号：WO2007101279A3
公开(公告)日：2008-05-08
申请号：PCT/US2007063348
申请日：2007-03-05
Applicant: CHEMIMAGE CORP , GARDNER CHARLES W , MAIER JOHN S , NELSON MATTHEW P , SCHWEITZER ROBERT C , TREADO PATRICK J , WANG CHENHUL , VANNI G STEVEN , WOLFE JULIANNE , DEMUTH JOSEPH E , NEISS JASON H
Inventor： GARDNER CHARLES W , MAIER JOHN S , NELSON MATTHEW P , SCHWEITZER ROBERT C , TREADO PATRICK J , WANG CHENHUL , VANNI G STEVEN , WOLFE JULIANNE , DEMUTH JOSEPH E , NEISS JASON H
IPC: G01J3/44
CPC classification number: G01J3/44 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0224 , G01J3/0237 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/0291 , G01J3/10 , G01J3/26 , G01J3/32 , G01J3/36 , G01J3/447 , G01N21/65 , G01N2201/0846
Abstract: The disclosure relates to a portable system having a fiber array spectral translator ("FAST") for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.
Abstract translation: 本公开涉及一种具有光纤阵列光谱转换器（“FAST”）的便携式系统，用于获得具有第一和第二空间尺寸的样品的空间上准确的波长分辨图像，所述第一和第二空间尺寸可用于通过照射来检测危险物质 具有光的样品，使用来自样品的拉曼移动光形成全部或部分样品的图像，并且分析拉曼偏移光以获得一种或多种危险剂的特征。
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公开(公告)号：WO2006028688A2
公开(公告)日：2006-03-16
申请号：PCT/US2005029745
申请日：2005-08-19
Applicant: CHEMIMAGE CORP , TUSCHEL DAVID , NELSON MATTHEW P , DEMUTH JOSEPH E
Inventor： TUSCHEL DAVID , NELSON MATTHEW P , DEMUTH JOSEPH E
CPC classification number: A61B1/00165 , A61B1/043 , A61B1/07 , A61B5/0075 , A61B5/0084 , G01J3/02 , G01J3/021 , G01J3/0218 , G01J3/0256 , G01J3/0264 , G01J3/0291 , G01J3/32 , G01J3/44 , G01J2003/1213 , G01N21/33 , G01N21/359 , G01N21/474 , G01N21/645 , G01N21/65 , G01N2021/3155 , G01N2021/4742 , G01N2021/6419 , G01N2021/6421 , G01N2021/6484 , G01N2021/656 , G02B6/06 , G02B6/29398 , G02B23/2423 , G02B23/2469
Abstract: The disclosure generally relates to a method and apparatus for a fiberscope. In one embodiment, the disclosure relates to a chemical imaging fiberscope for imaging and collecting optical spectra from a sample having at least one illumination fiber for transmitting light from a first an a second light source to a distal end of a fiberscope; a dichroic mirror disposed at said distal end of the fiberscope such that light from said first light source passes substantially straight through said mirror and light of a predetermined wavelength from said second light source is substantially reflected by said mirror toward said sample to thereby illuminate said sample; and at least one collection fiber for receiving light from said illuminated sample and transmitting the received light to an optical device.
Abstract translation: 本发明一般涉及一种纤维镜的方法和装置。 在一个实施方案中，本公开涉及一种用于从具有至少一个照明光纤的样品成像和收集光谱的化学成像光纤镜，用于将光从第一光源发射到纤维内窥镜的远端; 分光镜，设置在所述纤维内窥镜的所述远端处，使得来自所述第一光源的光基本上直线穿过所述反射镜，并且来自所述第二光源的预定波长的光被所述反射镜基本上反射到所述样品，从而照亮所述样品 ; 以及至少一个收集光纤，用于接收来自所述被照亮样品的光，并将所接收的光传输到光学装置。
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公开(公告)号：WO2005060380A3
公开(公告)日：2005-12-01
申请号：PCT/US2004020266
申请日：2004-06-24
Applicant: CHEMIMAGE CORP , GARDNER CHARLES W JR , MAIER JOHN S , NELSON MATTHEW P , SCHWEITZER ROBERT C , TREADO PATRICK J , VANNI G STEVEN , WOLFE JULIANNE
Inventor： GARDNER CHARLES W JR , MAIER JOHN S , NELSON MATTHEW P , SCHWEITZER ROBERT C , TREADO PATRICK J , VANNI G STEVEN , WOLFE JULIANNE
CPC classification number: G01J3/44 , G01J3/02 , G01J3/0272 , G01J3/10 , G01N21/35 , G01N21/3577 , G01N21/6458 , G01N21/6486 , G01N21/65 , G01N2021/6417 , G01N2021/6423 , G01N2021/656 , G01N2201/0221
Abstract: Pathogenic microorganisms are detected in a wide field of view and classified by Raman light scattered light from these organisms together with digital pattern recognition of their spectral patterns.
Abstract translation: 在广泛的视野中检测致病微生物，并通过来自这些生物的拉曼光散射光以及它们的光谱图案的数字图案识别来分类病原微生物。
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Patent Agency Ranking16.发明申请METHOD AND APPARATUS FOR COMPACT SPECTROMETER FOR DETECTING HAZARDOUS AGENTS 审中-公开用于检测危险剂的紧凑型光谱仪的方法和装置
公开(公告)号：WO2007120996A3
公开(公告)日：2008-10-30
申请号：PCT/US2007063344
申请日：2007-03-05
Applicant: CHEMIMAGE CORP , GARDNER CHARLES W , MAIER JOHN S , NELSON MATTHEW P , SCHWEITZER ROBERT C , TREADO PARTRICK J , VANNI G STEVEN , WOLFE JULIANNE , DEMUTH JOSEPH E , NEISS JASON H , WANG CHENHUI
Inventor： GARDNER CHARLES W , MAIER JOHN S , NELSON MATTHEW P , SCHWEITZER ROBERT C , TREADO PARTRICK J , VANNI G STEVEN , WOLFE JULIANNE , DEMUTH JOSEPH E , NEISS JASON H , WANG CHENHUI
CPC classification number: G01J3/44 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/0291 , G01J3/10 , G01J3/26 , G01J3/28 , G01J3/2823 , G01N21/6456 , G01N21/65 , G01N2021/6423 , G01N2201/0221
Abstract: The disclosure relates to a portable system for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.
Abstract translation: 本公开涉及一种便携式系统，用于获得具有第一和第二空间尺寸的样本的空间上准确的波长分辨图像，该图像可以用于通过用光照射样品来检测危险剂，形成全部或全部图像 使用拉曼的样品的一部分移动来自样品的光，并且分析拉曼偏移光以获得一种或多种危险剂的特征。
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17.发明申请SYSTEM AND METHOD FOR FIBER ARRAY SPECTRAL TRANSLATOR BASED POLYMORPH SCREENING 审中-公开用于光纤阵列光纤转换器的聚合物筛选系统和方法
公开(公告)号：WO2007103894A3
公开(公告)日：2008-04-03
申请号：PCT/US2007063341
申请日：2007-03-05
Applicant: CHEMIMAGE CORP , TUSCHEL DAVID , TREADO PATRICK J , NELSON MATTHEW P
Inventor： TUSCHEL DAVID , TREADO PATRICK J , NELSON MATTHEW P
IPC: G01J3/44
CPC classification number: G01J3/44 , G01J3/0221 , G01J3/2823 , G01N21/474 , G01N21/6456 , G01N21/65 , G01N2021/6423 , G01N2021/6484 , G01N2201/08 , G01N2201/0833
Abstract: The present disclosure describes methods and systems that combine Raman spectroscopy performed in a manner that utilizes one or more of widefield illumination, simultaneous multipoint Raman spectral acquisition, and spectral unmixing for the purpose of high throughput polymorph screening. Features of this methodology include: (a) high throughput polymorph screening to reduce crystal orientation effects on Raman spectra; (b) in- well multi-polymorph screening using increased statistical sampling; and (c) multipoint spectral sampling to enable spectral unmixing.
Abstract translation: 本公开描述了组合拉曼光谱的方法和系统，其以利用一种或多种宽场照明，同时多点拉曼光谱采集和光谱解混合的方式进行，以进行高通量多晶型筛选。 该方法的特点包括：（a）高通量多晶型筛选以减少对拉曼光谱的晶体取向效应; （b）使用增加的统计学抽样的多孔多态性筛选; 和（c）多点光谱采样以使光谱解混合。
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公开(公告)号：WO03060444A8
公开(公告)日：2003-11-13
申请号：PCT/US0300868
申请日：2003-01-10
Applicant: CHEMIMAGE CORP
Inventor： GARDNER CHARLES W JR , MAIER JOHN S , NELSON MATTHEW P , SCHWEITZER ROBERT C , TREADO PATRICK J , VANNI G STEVEN , WARE JULIANE
CPC classification number: G01N21/6486 , G01J3/02 , G01J3/0218 , G01J3/2823 , G01J3/44 , G01N21/31 , G01N21/33 , G01N21/359 , G01N21/645 , G01N21/6456 , G01N21/6458 , G01N21/65 , G01N2021/1736 , G01N2021/6421 , G01N2021/6423 , G01N2021/656
Abstract: Pathogenic microorganisms are detected and classified by spectral imaging of the Raman light scattered by the organisms.
Abstract translation: 通过生物体散射的拉曼光的光谱成像检测和分类病原微生物。
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19.发明申请METHOD AND APPARATUS FOR COMPACT SPECTROMETER FOR MULTIPOINT SAMPLING OF AN OBJECT 审中-公开用于多目标采样的紧凑型光谱仪的方法和装置
公开(公告)号：WO2007103897A3
公开(公告)日：2008-07-10
申请号：PCT/US2007063346
申请日：2007-03-05
Applicant: CHEMIMAGE CORP , GARDNER CHARLES W JR , MAIER JOHN S , NELSON MATTHEW P , SCHWEITZER ROBERT C , TREADO PATRICK J , VANNI G STEVEN , WOLFE JULIANNE , DEMUTH JOSEPH E , NEISS JASON H , WANG CHENHUI
Inventor： GARDNER CHARLES W JR , MAIER JOHN S , NELSON MATTHEW P , SCHWEITZER ROBERT C , TREADO PATRICK J , VANNI G STEVEN , WOLFE JULIANNE , DEMUTH JOSEPH E , NEISS JASON H , WANG CHENHUI
CPC classification number: G01N21/65 , G01N21/6456 , G01N2021/6421 , G01N2201/0221
Abstract: The disclosure relates to methods and apparatus for assessing occurrence of one or more hazardous agents in a sample by performing multipoint spectral analysis of the sample using a portable or hand-held device. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and systems suitable for performing such multipoint methods are also disclosed.
Abstract translation: 本公开涉及通过使用便携式或手持式装置对样品进行多点光谱分析来评估样品中一种或多种危险剂的发生的方法和装置。 公开了采用拉曼光谱法和其他分光光度法的方法。 还公开了适于执行这种多点方法的设备和系统。
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公开(公告)号：WO2006091223A3
公开(公告)日：2007-03-22
申请号：PCT/US2005023705
申请日：2005-06-30
Applicant: CHEMIMAGE CORP , NEISS JASON , NELSON MATTHEW P , TREADO PATRICK , SCHWEITZER ROBERT
Inventor： NEISS JASON , NELSON MATTHEW P , TREADO PATRICK , SCHWEITZER ROBERT
CPC classification number: G01J3/44 , G01J3/10 , G01J3/32 , G01N21/21 , G01N21/6428 , G01N21/6458 , G01N21/65 , G01N2021/6417 , G01N2021/6484 , G01N2021/656
Abstract: The invention relates to apparatus and methods for assessing occurrence of a hazardous agent in a sample by performing multimodal spectral analysis of the sample. Methods of employing Raman spectroscopy for entities in a sample which exhibit one or more optical properties characteristic of a hazardous agent are disclosed. Devices and systems suitable for performing such methods are also disclosed.
Abstract translation: 本发明涉及通过对样品进行多峰频谱分析来评估样品中危险剂的发生的装置和方法。 公开了对具有特征性危险物质的一种或多种光学特性的样品中的实体采用拉曼光谱的方法。 还公开了适于执行这些方法的装置和系统。
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