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    FORENSIC INTEGRATED SEARCH TECHNOLOGY
    11.
    发明申请
    FORENSIC INTEGRATED SEARCH TECHNOLOGY 审中-公开
    威信集成搜索技术

    公开(公告)号：WO2006135806A3

    公开(公告)日：2008-05-02

    申请号：PCT/US2006022618

    申请日：2006-06-09

    Applicant: CHEMIMAGE CORP ,  TREADO PATRICK J ,  SCHWEITZER ROBERT ,  NEISS JASON

    Inventor： TREADO PATRICK J ,  SCHWEITZER ROBERT ,  NEISS JASON

    IPC: G06F17/30 ,  G06F19/00 ,  G06F19/28

    CPC classification number: G06F17/30536 ,  G06F19/703 ,  G06F19/709

    Abstract: A system and method to search spectra databases and to identify unknown materials. A library having a plurality of sublibraries is provided wherein each sublibrary contains a plurality of reference data sets generated by a corresponding one of a plurality of spectroscopic data generating instruments associated with the sublibrary. Each reference data set characterizes a corresponding known material. A plurality of test data sets is provided that is characteristic of an unknown material, wherein each test data set is generated by one or more of the plurality of spectroscopic data generating instalments. For each test data set, each sublibrary is searched where the sublibrary is associated with the spectroscopic data generating instrument used to generate the test data set

    Abstract translation: 搜索光谱数据库并识别未知材料的系统和方法。 提供具有多个子图库的库，其中每个子图库包含由与该子图书馆相关联的多个光谱数据生成装置中的相应一个生成的多个参考数据集。 每个参考数据集表征相应的已知材料。 提供了多个测试数据集，其是未知材料的特征，其中每个测试数据集由多个光谱数据产生分段中的一个或多个产生。 对于每个测试数据集，搜索每个子图书馆，其中子图书馆与用于生成测试数据集的光谱数据生成工具相关联

    DIGITIZING BIOLOGY
    12.
    发明申请
    DIGITIZING BIOLOGY 审中-公开
    数字化生物

    公开(公告)号：WO2007011571A3

    公开(公告)日：2007-06-07

    申请号：PCT/US2006026777

    申请日：2006-07-11

    Applicant: CHEMIMAGE CORP ,  MAIER JOHN S ,  TREADO PATRICK J ,  COHEN JEFFREY ,  NEISS JASON

    Inventor： MAIER JOHN S ,  TREADO PATRICK J ,  COHEN JEFFREY ,  NEISS JASON

    IPC: A61B5/00 ,  G01J3/00 ,  G01J5/02

    CPC classification number: G01N21/65

    Abstract: A method and apparatus for determining the progress of a disease. A pre-determined vector space is determined where the vector space mathematically describes a reference set of wavelength resolved data at a plurality of time intervals. A sample containing at least one cell is irradiated with light. Target data is collected where the target data corresponds to at least one of light emitted from or scattered by the sample and includes a plurality of spatially accurate wavelength resolved measurements of light. The target data is transformed into the pre-determined vector space for each spatially accurate wavelength resolved measurement of light. A distribution of transformed points is analyzed in the plurality of pre-determined vector space. Based on the analysis, a transition of a disease condition of the sample is classified.

    Abstract translation: 一种确定疾病进展的方法和装置。 在矢量空间以多个时间间隔在数学上描述波长分解数据的参考集的情况下确定预定向量空间。 用光照射包含至少一个细胞的样品。 在目标数据对应于由样本发射或散射的光中的至少一个的情况下收集目标数据，并且包括多个空间精确的波长分辨测量的光。 对于每个空间精确的波长分辨测量光，目标数据被转换成预定矢量空间。 在多个预定向量空间中分析变换点的分布。 基于分析，将样品疾病状况的转变分类。

    METHOD AND APPARATUS FOR VARIABLE-FIELD ILLUMINATION
    13.
    发明申请
    METHOD AND APPARATUS FOR VARIABLE-FIELD ILLUMINATION 审中-公开
    用于可变场照明的方法和装置

    公开(公告)号：WO2006083715A3

    公开(公告)日：2007-05-10

    申请号：PCT/US2006002975

    申请日：2006-01-30

    Applicant: CHEMIMAGE CORP ,  VOIGHT THOMAS ,  ZHANG JINGYUN ,  TREADO PATRICK J ,  TUSCHEL DAVID

    Inventor： VOIGHT THOMAS ,  ZHANG JINGYUN ,  TREADO PATRICK J ,  TUSCHEL DAVID

    IPC: G01J3/44

    CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0224 ,  G01N21/65

    Abstract: The disclosure relates to identifying one or more regions (100) of interest within a broader field of view (104) of a dynamic sample using one or more optical components (110 & 120) and illuminating photons. Once the region of interest (100) is identified within a section of the broader field of view (104), chemical information in the form of Raman spectrum is obtained from the region of interes (100) by focusing the illuminating photons of the optical components (110 & 120) on the region of interest (100).

    Abstract translation: 本公开涉及使用一个或多个光学部件（110和120）和照射光子来识别动态样品的更宽视场（104）内的感兴趣的一个或多个区域（100）。 一旦在较宽视场（104）的一部分内识别出感兴趣区域（100），则通过聚焦光学部件的照明光子，从内部区域（100）获得呈拉曼光谱形式的化学信息 （100）上的（110和120）。

    METHOD AND APPLICATIONS TO ENHANCE AND IMAGE OPTICAL SIGNALS FROM BIOLOGICAL OBJECTS
    14.
    发明申请
    METHOD AND APPLICATIONS TO ENHANCE AND IMAGE OPTICAL SIGNALS FROM BIOLOGICAL OBJECTS 审中-公开
    从生物学对象增强和图像光学信号的方法和应用

    公开(公告)号：WO2006113537A2

    公开(公告)日：2006-10-26

    申请号：PCT/US2006014252

    申请日：2006-04-14

    Applicant: CHEMIMAGE CORP ,  DEMUTH JOSEPH ,  TUSCHEL DAVID ,  MAIER JOHN S ,  TREADO PATRICK J

    Inventor： DEMUTH JOSEPH ,  TUSCHEL DAVID ,  MAIER JOHN S ,  TREADO PATRICK J

    IPC: G01J3/44 ,  G01N21/65

    CPC classification number: G01J3/44 ,  G01J3/32 ,  G01N21/658

    Abstract: A method and apparatus for imaging biological objects. A SERS surface is provided having enhancing structures uniformly distributed on the surface. The surface includes a two dimensional area of at least 5 x 105 nm. The enhancing structures may have a size, in at least one dimension of height, width and length, ranging from 100 nm to 1000 nm. A biological material is deposited on the SERS surface. The biological material on the SERS surface is illuminated using a monochromatic light source producing Raman scattered photons. The Raman scattered photons are filtered using a tunable filter into a plurality of predetermined wavelength bands. A two-dimensional array detector detects the filtered Raman scattered photons, in a spatially accurate manner. The results of filtering and detecting steps are combined to produce a plurality of spectrally resolved Raman images of the biological material.

    Abstract translation: 一种用于成像生物体的方法和装置。 提供了具有均匀分布在表面上的增强结构的SERS表面。 该表面包括至少5×105nm的二维区域。 增强结构可以在100nm至1000nm范围内的高度，宽度和长度的至少一个尺寸中具有尺寸。 生物材料沉积在SERS表面上。 使用产生拉曼散射光子的单色光源照射SERS表面上的生物材料。 使用可调滤波器将拉曼散射光子滤波成多个预定波长带。 二维阵列检测器以空间准确的方式检测经过滤波的拉曼散射光子。 滤波和检测步骤的结果被组合以产生生物材料的多个光谱分辨的拉曼图像。

    SYSTEM AND METHOD FOR SUPER RESOLUTION OF A SAMPLE IN A FIBER ARRAY SPECTRAL TRANSLATOR SYSTEM
    15.
    发明申请
    SYSTEM AND METHOD FOR SUPER RESOLUTION OF A SAMPLE IN A FIBER ARRAY SPECTRAL TRANSLATOR SYSTEM 审中-公开
    在光纤阵列传输系统中超分辨率的系统和方法

    公开(公告)号：WO2007117764A3

    公开(公告)日：2008-10-02

    申请号：PCT/US2007062080

    申请日：2007-02-13

    Applicant: CHEMIMAGE CORP ,  NELSON MATTHEW P ,  NEISS JASON H ,  TREADO PATRICK J

    Inventor： NELSON MATTHEW P ,  NEISS JASON H ,  TREADO PATRICK J

    IPC: G01J3/00 ,  G01N21/00

    CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/0221 ,  G01J3/28 ,  G01J3/2803 ,  G01J3/2823 ,  G01N21/255 ,  G01N21/274 ,  G01N2201/0833

    Abstract: The disclosure relates generally to methods and apparatus for obtaining a super resolution image of a sample using a fiber array spectral translator system. In one embodiment includes collecting photons from a sample at a first end of a fiber array spectral translator; delivering the photons from a second end of the fiber array spectral translator into a multiple detector rows of a photon detector; interpolating between the multiple detector rows to thereby form interpolated rows; and arranging an output of the multiple detector rows and the interpolated rows so as to obtain a super resolution image of the sample.

    Abstract translation: 本公开一般涉及使用光纤阵列频谱转换器系统获得样本的超分辨率图像的方法和装置。 在一个实施例中，包括在光纤阵列光谱转换器的第一端收集来自样品的光子; 将光子从光纤阵列频谱转换器的第二端传送到光子检测器的多个检测器行中; 在多个检测器行之间内插，从而形成内插行; 并且布置多个检测器行和内插行的输出，以便获得样本的超分辨率图像。

    SYSTEM AND METHOD FOR SPECTRAL UNMIXING IN A FIBER ARRAY SPECTRAL TRANSLATOR BASED POLYMORPH SCREENING SYSTEM
    17.
    发明申请
    SYSTEM AND METHOD FOR SPECTRAL UNMIXING IN A FIBER ARRAY SPECTRAL TRANSLATOR BASED POLYMORPH SCREENING SYSTEM 审中-公开
    基于光纤光栅转换器的聚合物筛选系统的光谱分析系统与方法

    公开(公告)号：WO2007101163A2

    公开(公告)日：2007-09-07

    申请号：PCT/US2007062822

    申请日：2007-02-26

    Applicant: CHEMIMAGE CORP ,  NEISS JASON H ,  TREADO PATRICK J ,  SCHWEITZER ROBERT

    Inventor： NEISS JASON H ,  TREADO PATRICK J ,  SCHWEITZER ROBERT

    CPC classification number: G01J3/2803 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0221 ,  G01J3/024 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/04 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/65 ,  G01N2201/0833 ,  G01N2201/1293

    Abstract: The disclosure relates generally to methods and apparatus for using a fiber array spectral translator-based ("FAST") spectroscopic system for performing spectral unmixing of a mixture containing multiple polymorphs. In an embodiment, a first spectrum of a mixture containing polymorphs of a compound is obtained using a photon detector and a fiber array spectral translator having plural fibers. A set of second spectra is provided where each spectrum of the set of second spectra may be representative of a different polymorph of the compound. The first spectrum and the set of second spectra may be compared, and based on the comparison, the presence of one or more polymorphs in the mixture may be determined.

    Abstract translation: 本公开一般涉及使用用于执行含有多个多晶型物的混合物的光谱解混合的光纤阵列光谱转换器（“FAST”）光谱系统的方法和装置。 在一个实施方案中，使用具有多个纤维的光子检测器和光纤阵列光谱转换器获得含有化合物多晶型物的混合物的第一光谱。 提供了一组第二光谱，其中该组第二光谱的每个光谱可以代表该化合物的不同多晶型物。 可以比较第一光谱和第二光谱集合，并且基于比较，可以确定混合物中一个或多个多晶型物的存在。

    DYNAMIC CHEMICAL IMAGING OF BIOLOGICAL CELLS AND OTHER SUBJECTS
    18.
    发明申请
    DYNAMIC CHEMICAL IMAGING OF BIOLOGICAL CELLS AND OTHER SUBJECTS 审中-公开
    动物化学成像生物细胞和其他物种

    公开(公告)号：WO2006005022A3

    公开(公告)日：2006-06-15

    申请号：PCT/US2005023638

    申请日：2005-06-30

    Applicant: CHEMIMAGE CORP ,  MAIER JOHN S ,  TREADO PATRICK J ,  VOIGT THOMAS C ,  TUSCHEL DAVID

    Inventor： MAIER JOHN S ,  TREADO PATRICK J ,  VOIGT THOMAS C ,  TUSCHEL DAVID

    IPC: G01J3/44 ,  G01N21/65

    CPC classification number: G01N21/6456 ,  G01J3/2803 ,  G01J3/32 ,  G01J3/36 ,  G01J3/44 ,  G01N21/359 ,  G01N21/6486 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/656

    Abstract: The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic light and assessing Raman-shifted light scattered from the illuminated portion at a plurality of discrete times. The Raman-shifted light can be assessed at a plurality of Raman shift (RS) values at each of the discrete times, and the RS values can be selected to be characteristic of a pre-selected component at each of the discrete times. Multivariate analysis of Raman spectral features of the images thus obtained can yield the location and chemical identity of components in the field of view. This information can be combined or overlaid with other spectral data (e.g., a visible microscopic image) obtained from the field of view.

    Abstract translation: 本发明涉及动态化学成像方法，包括细胞成像方法。 该方法包括以基本上单色的光照亮电池的至少一部分，并且在多个离散时间评估从照射部分散射的拉曼偏移光。 可以在每个离散时间处以多个拉曼位移（RS）值评估拉曼移位的光，并且可以将每个离散时间的RS值选择为预选择的分量的特征。 如此获得的图像的拉曼光谱特征的多变量分析可以产生视场中部件的位置和化学特性。 该信息可以与从视野获得的其他光谱数据（例如，可见显微镜图像）组合或覆盖。

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