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    MULTIMODAL METHOD FOR IDENTIFYING HAZARDOUS AGENTS
    1.
    发明专利
    MULTIMODAL METHOD FOR IDENTIFYING HAZARDOUS AGENTS 未知

    公开(公告)号：CA2571932A1

    公开(公告)日：2006-08-31

    申请号：CA2571932

    申请日：2005-06-30

    Applicant: CHEMIMAGE CORP

    Inventor： SCHWEITZER ROBERT ,  TREADO PATRICK ,  NEISS JASON ,  NELSON MATTHEW P

    IPC: G01J3/44

    Abstract: The invention relates to apparatus and methods for assessing occurrence of a hazardous agent in a sample by performing multimodal spectral analysis of the sample. Methods of employing Raman spectroscopy for entities in a sample which exhibit one or more optical properties characteristic of a hazardous agent are disclosed. Devices and systems suitable for performing such methods are also disclosed.

    DIGITIZING BIOLOGY
    2.
    发明专利
    DIGITIZING BIOLOGY 未知

    公开(公告)号：CA2614319A1

    公开(公告)日：2007-01-25

    申请号：CA2614319

    申请日：2006-07-11

    Applicant: CHEMIMAGE CORP

    Inventor： MAIER JOHN S ,  TREADO PATRICK J ,  NEISS JASON ,  COHEN JEFFREY

    IPC: A61B5/00 ,  G01J3/00 ,  G01J5/02

    Abstract: A method and apparatus for determining the progress of a disease. A pre- determined vector space is determined where the vector space mathematically describes a reference set of wavelength resolved data at a plurality of time intervals. A sample containing at least one cell is irradiated with light. Target data is collected where the target data corresponds to at least one of light emitted from or scattered by the sample and includes a plurality of spatially accurate wavelength resolved measurements of light. The target data is transformed into the pre-determined vector space for each spatially accurate wavelength resolved measurement of light. A distribution of transformed points is analyzed in the plurality of pre-determined vector space. Based on the analysis, a transition of a disease condition of the sample is classified.

    TIME AND SPACE RESOLVED STANDOFF HYPERSPECTRAL IED EXPLOSIVES LIDAR DETECTOR
    3.
    发明申请
    TIME AND SPACE RESOLVED STANDOFF HYPERSPECTRAL IED EXPLOSIVES LIDAR DETECTOR 审中-公开
    时间和空间分辨率高分辨率高分辨率激光雷达探测器

    公开(公告)号：WO2007123555A3

    公开(公告)日：2008-01-31

    申请号：PCT/US2006022647

    申请日：2006-06-09

    Applicant: CHEMIMAGE CORP ,  TREADO PATRICK J ,  NELSON MATTHEW P ,  HUBBLE HUGH W II ,  NEISS JASON

    Inventor： TREADO PATRICK J ,  NELSON MATTHEW P ,  HUBBLE HUGH W II ,  NEISS JASON

    IPC: G01N21/00 ,  G01J3/30 ,  G01J3/44

    CPC classification number: G01J3/36 ,  G01J3/02 ,  G01J3/0221 ,  G01J3/0264 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/359 ,  G01N21/6456 ,  G01N21/65 ,  G01N21/718 ,  G01N2021/1738 ,  G01N2021/174 ,  G01N2021/1744

    Abstract: A system and method for standoff detection of explosives and explosive residue. A laser light source illuminates a target area having an unknown sample producing luminescence emitted photons, scattered photons and plasma emitted photons. A first optical system directs light to the target area. A video capture device outputs a dynamic image of the target area. A second optical system collects photons, and directs collected photons to a first two-dimensional array of detection elements and/or to a fiber array spectral translator device which device includes a two-dimensional array of optical fibers drawn into a one-dimensional fiber stack. A spectrograph is coupled to the one-dimensional fiber stack of the fiber array spectral translator device, wherein the entrance slit of the spectrograph is coupled to the one dimensional fiber stack.

    Abstract translation: 爆炸物和爆炸物残留物检测的系统和方法。 激光源照射具有未知样品的目标区域，产生发光的光子，散射的光子和等离子体发射的光子。 第一光学系统将光引导到目标区域。 视频采集装置输出目标区域的动态图像。 第二光学系统收集光子，并将收集的光子引导到检测元件的第一二维阵列和/或光纤阵列光谱转换器装置，该装置包括被拉入一维光纤堆叠的光纤的二维阵列 。 光谱仪耦合到光纤阵列光谱转换器装置的一维光纤堆叠，其中光谱仪的入口狭缝耦合到一维光纤堆叠。

    SYSTEM AND METHOD FOR CLASIFYING CELLS AND THE PHARMACEUTICAL TREATMENT OF SUCH CELLS USING RAMAN SPECTROSCOPY
    4.
    发明申请
    SYSTEM AND METHOD FOR CLASIFYING CELLS AND THE PHARMACEUTICAL TREATMENT OF SUCH CELLS USING RAMAN SPECTROSCOPY 审中-公开
    使用拉曼光谱法分离细胞的系统和方法以及这种细胞的药物治疗

    公开(公告)号：WO2007081874A2

    公开(公告)日：2007-07-19

    申请号：PCT/US2007000397

    申请日：2007-01-05

    Applicant: CHEMIMAGE CORP ,  PANZA JANICE L ,  MAIER JOHN ,  NEISS JASON

    Inventor： PANZA JANICE L ,  MAIER JOHN ,  NEISS JASON

    IPC: G01J3/44 ,  G01N21/65

    CPC classification number: G01J3/44 ,  G01J3/28 ,  G01J3/36 ,  G01N15/1475 ,  G01N21/65 ,  G01N2015/1006 ,  G01N2015/1488 ,  G01N2021/656

    Abstract: A system and method to distinguish normal cells from apoptotic cells. A pre-determined vector space is selected where the vector space mathematically describes a first plurality of reference Raman data sets for normal cells and a second plurality of reference Raman data sets for apoptotic cells. A sample is irradiated with substantially monochromatic light generating a target Raman data set based on scattered photons. The target Raman data set is transformed into a vector space defined by the pre-determined vector space. A distribution of transformed data is analyzed in the pre-determined vector space. Based on the analysis, the sample is classified as containing normal cells, apoptotic cells, and a combination of normal and apoptotic cells. The sample includes the step of treating the sample with a pharmaceutical agent prior to irradiating the sample. Based on the classification, the therapeutic efficiency of the pharmaceutical agent is assessed.

    Abstract translation: 将正常细胞与凋亡细胞区分开的系统和方法。 选择预定矢量空间，其中矢量空间在数学上描述用于正常细胞的第一多个参考拉曼数据集和用于凋亡细胞的第二多个参考拉曼数据集。 用基本上单色的光照射样品，产生基于散射光子的目标拉曼数据集。 目标拉曼数据集被转换成由预定向量空间定义的向量空间。 在预定向量空间中分析变换数据的分布。 基于分析，样品被分类为含有正常细胞，凋亡细胞，以及正常细胞和凋亡细胞的组合。 样品包括在照射样品之前用药剂处理样品的步骤。 根据分类，评估药剂的治疗效果。

    FORENSIC INTEGRATED SEARCH TECHNOLOGY
    5.
    发明申请
    FORENSIC INTEGRATED SEARCH TECHNOLOGY 审中-公开
    威信集成搜索技术

    公开(公告)号：WO2006135806A3

    公开(公告)日：2008-05-02

    申请号：PCT/US2006022618

    申请日：2006-06-09

    Applicant: CHEMIMAGE CORP ,  TREADO PATRICK J ,  SCHWEITZER ROBERT ,  NEISS JASON

    Inventor： TREADO PATRICK J ,  SCHWEITZER ROBERT ,  NEISS JASON

    IPC: G06F17/30 ,  G06F19/00 ,  G06F19/28

    CPC classification number: G06F17/30536 ,  G06F19/703 ,  G06F19/709

    Abstract: A system and method to search spectra databases and to identify unknown materials. A library having a plurality of sublibraries is provided wherein each sublibrary contains a plurality of reference data sets generated by a corresponding one of a plurality of spectroscopic data generating instruments associated with the sublibrary. Each reference data set characterizes a corresponding known material. A plurality of test data sets is provided that is characteristic of an unknown material, wherein each test data set is generated by one or more of the plurality of spectroscopic data generating instalments. For each test data set, each sublibrary is searched where the sublibrary is associated with the spectroscopic data generating instrument used to generate the test data set

    Abstract translation: 搜索光谱数据库并识别未知材料的系统和方法。 提供具有多个子图库的库，其中每个子图库包含由与该子图书馆相关联的多个光谱数据生成装置中的相应一个生成的多个参考数据集。 每个参考数据集表征相应的已知材料。 提供了多个测试数据集，其是未知材料的特征，其中每个测试数据集由多个光谱数据产生分段中的一个或多个产生。 对于每个测试数据集，搜索每个子图书馆，其中子图书馆与用于生成测试数据集的光谱数据生成工具相关联

    DIGITIZING BIOLOGY
    6.
    发明申请
    DIGITIZING BIOLOGY 审中-公开
    数字化生物

    公开(公告)号：WO2007011571A3

    公开(公告)日：2007-06-07

    申请号：PCT/US2006026777

    申请日：2006-07-11

    Applicant: CHEMIMAGE CORP ,  MAIER JOHN S ,  TREADO PATRICK J ,  COHEN JEFFREY ,  NEISS JASON

    Inventor： MAIER JOHN S ,  TREADO PATRICK J ,  COHEN JEFFREY ,  NEISS JASON

    IPC: A61B5/00 ,  G01J3/00 ,  G01J5/02

    CPC classification number: G01N21/65

    Abstract: A method and apparatus for determining the progress of a disease. A pre-determined vector space is determined where the vector space mathematically describes a reference set of wavelength resolved data at a plurality of time intervals. A sample containing at least one cell is irradiated with light. Target data is collected where the target data corresponds to at least one of light emitted from or scattered by the sample and includes a plurality of spatially accurate wavelength resolved measurements of light. The target data is transformed into the pre-determined vector space for each spatially accurate wavelength resolved measurement of light. A distribution of transformed points is analyzed in the plurality of pre-determined vector space. Based on the analysis, a transition of a disease condition of the sample is classified.

    Abstract translation: 一种确定疾病进展的方法和装置。 在矢量空间以多个时间间隔在数学上描述波长分解数据的参考集的情况下确定预定向量空间。 用光照射包含至少一个细胞的样品。 在目标数据对应于由样本发射或散射的光中的至少一个的情况下收集目标数据，并且包括多个空间精确的波长分辨测量的光。 对于每个空间精确的波长分辨测量光，目标数据被转换成预定矢量空间。 在多个预定向量空间中分析变换点的分布。 基于分析，将样品疾病状况的转变分类。

    METHOD AND SYSTEM FOR COMBINED RAMAN AND LIBS DETECTION
    7.
    发明申请
    METHOD AND SYSTEM FOR COMBINED RAMAN AND LIBS DETECTION 审中-公开
    用于组合拉曼和LIBS检测的方法和系统

    公开(公告)号：WO2007087315A3

    公开(公告)日：2008-07-31

    申请号：PCT/US2007001799

    申请日：2007-01-23

    Applicant: CHEMIMAGE CORP ,  BECKSTEAD JEFFREY ,  TREADO PATRICK J ,  NELSON MATTHEW ,  HUBBLE HUGH W II ,  NEISS JASON

    Inventor： BECKSTEAD JEFFREY ,  TREADO PATRICK J ,  NELSON MATTHEW ,  HUBBLE HUGH W II ,  NEISS JASON

    IPC: G01J3/44

    CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0272 ,  G01J3/28 ,  G01J3/443 ,  G01N21/65 ,  G01N21/718

    Abstract: In one embodiment, the disclosure relates to a method for interrogating a sample by: illuminating a first region of the sample with a first illumination pattern to obtain a plurality of first sample photons; illuminating a second region of the sample with a second illumination pattern to obtain a plurality of second sample photons; processing the plurality of first sample photons to obtain a characteristic atomic emission of the first region and processing the plurality of second sample photons to obtain a Raman spectrum; and identifying the sample through at least one of the characteristic atomic emission of the first region or the Raman spectrum of the second region of the sample.

    Abstract translation: 在一个实施例中，本公开涉及一种用于询问样本的方法，其中：用第一照明图案照射样品的第一区域以获得多个第一样品光子; 用第二照明图案照射样品的第二区域以获得多个第二样品光子; 处理多个第一样品光子以获得第一区域的特征原子发射并处理多个第二样品光子以获得拉曼光谱; 以及通过样品的第二区域的第一区域的特征性原子发射或拉曼光谱中的至少一个来识别样品。

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