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    Vessel construction for a particle study device
    12.
    发明专利
    Vessel construction for a particle study device 未知

    公开(公告)号：GB1125289A

    公开(公告)日：1968-08-28

    申请号：GB3847865

    申请日：1965-09-08

    Applicant: COULTER ELECTRONICS

    Inventor： MORGAN CHARLES TRAFTON ,  COULTER WALLACE HENRY

    IPC: G01N15/12

    Abstract: 1,125,289. Counting particles. COULTER ELECTRONICS Ltd. Sept. 8, 1965, No. 38478/65. Heading G1N. Particle study apparatus operating on the Coulter principle is constructed so that all the particles in a sample can be studied and subsequently recovered. Vessels 12, 14 are clamped together to define a sealed chamber 54 which is connected by an outlet pipe 38 to a vacuum source. A wafer 36 having a small aperture is secured to vessel 12 coaxially with an orifice in the bottom thereof, for example as described in Specification 907, 028. A platinum electrode is deposited coaxially with the orifice and is connected by a similarly deposited strip 70 to terminal 74. The sample to be studied is placed in vessel 12 and is drawn through the aperture. When all the liquid in vessel 12 has passed through the aperture additional liquid may be added to carry any particles remaining in vessel 12 through the aperture. After a test the apparatus may be dismantled and the particles recovered from vessel 14. The apparatus may be used for studying metered portions of a sample if a metering device as described in Specification 865, 069 is used. The particles may be of gold or platinum.

    Automatic diluting apparatus
    13.
    发明专利
    Automatic diluting apparatus 未知

    公开(公告)号：GB1026310A

    公开(公告)日：1966-04-14

    申请号：GB4815563

    申请日：1963-12-05

    Applicant: COULTER ELECTRONICS

    Inventor： COULTER WALLACE HENRY

    IPC: G01N1/38

    Abstract: 1,026,310. Delivering measured quantities of liquids; sampling liquids. COULTER ELECTRONICS Inc. Dec. 5, 1963, No. 48155/63. Heading B8N. [Also in Divisions B1 and F1] An automatic diluting apparatus comprises a conduit system having operably connected thereto two vessels the volume of each being controllably variable and both of which are filled with a fluid diluent, a predetermined quantity of a fluid concentrate being introduced into the conduit system by increasing the volume of one of the vessels by a predetermined amount, whence a known volume of fluid diluent is discharged by controlled alteration of the volume of the other vessel, said discharge fluid also carrying with it the said quantity of fluid concentrate. In a specific embodiment of the apparatus, Fig. 1, diluent under pressure is fed through tube 55 to valve 66 and hence into cylinder 30 via tube 45, to move the piston 38 between stops 40 and 44 and thus displace a predetermined volume of diluent through tube 47; this volume may be varied by adjusting the size of the piston or the stops. The apparatus is filled with diluent and the sampling nozzle 58 placed in a vessel 65 containing concentrate, a predetermined quantity of which is drawn up into tube 58 by controllably withdrawing the plunger 122 located in vessel 72 which is joined to tube 60. When the concentrate has been taken up, the vessel 65 is replaced by a clean vessel and the nozzle 58 wiped free of sample. The valve 66 is then rotated through 90 degrees and due to pressure from 55 on piston 38, the diluent in cylinder 30 is displaced through tubes 45 and 60, thus displacing the concentrate into the clean vessel and also diluting it to a known degree.

    14.
    发明专利
    未知

    公开(公告)号：DK140735B

    公开(公告)日：1979-11-05

    申请号：DK556170

    申请日：1970-11-02

    Applicant: COULTER ELECTRONICS

    Inventor： HOGG WALTER ROBERT ,  COULTER WALLACE HENRY

    IPC: G01N15/12 ,  G01N15/02

    Abstract: 1281819 Particle analyzing apparatus COULTER ELECTRONICS Ltd 2 Nov 1970 [6 Nov 1969] 52046/70 Heading G1N In particle counting and sizing apparatus of the Coulter type, the aperture wafer includes at least one conical recess 44, Fig.1, or 64 and 66, Fig.5, communicating as shown with the aperture 42 or 62. If only one recess, the unrecessed surface of the wafer faces upstream. The wafer is fused to glass tube 80, Fig. 8, with its surface slightly proud.

    15.
    发明专利
    未知

    公开(公告)号：DE2504755A1

    公开(公告)日：1975-08-07

    申请号：DE2504755

    申请日：1975-02-05

    Applicant: COULTER ELECTRONICS

    Inventor： COULTER WALLACE HENRY ,  HOGG WALTER ROBERT

    IPC: G01N15/12 ,  G06M11/00 ,  G01N15/06

    Abstract: An apparatus for studying particles of widely different sizes includes a vessel and a fluid medium in the vessel with the particles suspended thereon. First and second aperture tubes are suspended in the vessel at a first height, and a third aperture tube is suspended at a second lower height. The first aperture tube has an aperture of substantially smaller size than the second and third aperture tubes. The rate of entry through the aperture and into the second tube, of particles large enough to cause blockage of the first aperture in the first tube, is detected. When this rate drops below a first particular rate, indicating that substantially all particles greater than that size have settled below this particular height in the beaker, control circuitry is actuated to enable the fluid to enter into the first tube via the aperture therein for analyzing particles received therein via Coulter type detectors.

    16.
    发明专利
    未知

    公开(公告)号：DE2445411A1

    公开(公告)日：1975-05-07

    申请号：DE2445411

    申请日：1974-09-23

    Applicant: COULTER ELECTRONICS

    Inventor： HOGG WALTER ROBERT ,  COULTER WALLACE HENRY ,  GINSBERG GUENTER ,  PRONI OSCAR ,  GODIN THOMAS J

    IPC: G01N1/38 ,  G01N15/12 ,  G01N15/00

    Abstract: 1479901 Electro-physical measurement; particle analysis COULTER ELECTRONICS Ltd 23 Sept 1974 [26 Sept 1973] 41368/74 Heading G1N(C) In a Coulter type particle analyzer, a "twochamber" tube is provided whereby clean electrolyte can be flowed past the aperture to waste, in a manner similar to that disclosed in Specification 1341336 and a constriction in the flow-path is arranged to increase the velocity behind the aperture. OVERALL SYSTEM FIG. 1. A double tube 13 is sealed into a coupling block 19 attached by screws 59 to the head-block 58, for easy interchange. The electrolyte system is electrically isolated from waste 42 and supply reservoir 52 by drip feed tanks 24, 29. The sample and electrolyte are moved through the apparatus by vacuum applied to the waste drip tank 24. The clean electrolyte flow is regulated by a constriction 27. Several variations of double tube construction are disclosed with reference to Figs. 2 ... 13 which are substantially self explanatory. Figs. 2, 5, 6, 7 only are shown as typical.

    18.
    发明专利
    未知

    公开(公告)号：DE1524570B1

    公开(公告)日：1972-01-20

    申请号：DE1524570

    申请日：1966-10-20

    Applicant: COULTER ELECTRONICS

    Inventor： COULTER WALLACE HENRY ,  HOGG WALTER ROBERT

    IPC: G01N15/12 ,  G01N33/487 ,  G01N33/49 ,  G01N33/16

    Abstract: 1,162,941. Measuring hematocrit index of blood electrically. COULTER ELECTRONICS Ltd. Oct. 13, 1966 [Oct. 20, 1965], No.45896/66. Heading G1N. Apparatus for automatically measuring the ratio of the total volume of red cells of a given sample of whole blood to the total volume of that sample comprises a Coulter type of cell counting and sizing apparatus 10, having a first output channel 38 which delivers cell counting information to an integrator 23 and a second output channel 34 which delivers cell counting and cell sizing information to a mean cell volume computer 22, and an analog computer 75 for multiplying the cell count by the mean cell volume thereby to determine the hematocrit index. As shown in Fig. 1, a metering device 20, such as described in Specification 865, 069, delivers a known volume of a sample comprising blood diluted with an electrolyte to a Coulter scanner 12, such as described in Specification 907, 028. The output of integrator 23 is corrected in accordance with known statistics for coincidence (two cells being detected together) before being applied across terminals 71, 72 of a potentiometer 58. The wiper of the potentiometer is driven by a motor 49 forming part of a servoamplifier and its position is dependent on the mean cell volume whereby the voltage of the wiper tap 60 is proportional to the hematocrit index. This voltage is passed to a second servo-amplifier wherein the angular position of a scale 83 relative to an index mark 84 indicates the hematocrit index. A common reference voltage 63 is used for both servo-amplifiers. The integrator 23 may be arranged to de-energize the detecting means when the integrator has become saturated.

    Apparatus for Particle Classification and Analysis
    19.
    发明专利
    Apparatus for Particle Classification and Analysis 未知

    公开(公告)号：GB1185898A

    公开(公告)日：1970-03-25

    申请号：GB4413867

    申请日：1967-09-28

    Applicant: COULTER ELECTRONICS

    Inventor： COULTER WALLACE HENRY ,  HOGG WALTER ROBERT

    IPC: G01N15/12 ,  G01R27/02 ,  H03K5/26

    Abstract: 1,185,898. Particle counting apparatus. COULTER ELECTRONICS Ltd. (W.H. Coulter). Sept.28, 1967, No.44138/67. Heading G1N. In a "Coulter counter" it has been found that the impedance of different kinds of particle varies with the supply frequency, especially at R.F. The Specification describes at length how this may be used to derive "signatures" for different kinds of particles using pulse counting and phase/ frequency measuring techniques. In a simple case the "gap" may be energized with a single R.F. and measurements made of either the resistive and reactive components using a phase sensitive detector, or the frequency modulation and amplitude modulation components of the signal. Pulses, (due to the passage of a particle), for each component of the signal having an amplitude within predetermined limits may be counted. In a more sophisticated arrangement three frequencies are applied simultaneously e.g. a D.C. or low frequency and two different R. F. S. The signal is analyzed into the amplitude of the D. C. and the quadrature components of each R. F. to provide a detailed signature. Compensation for source impedance may be provided by tuning the sensing zone to anti-resonance at the supply frequency.

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