公开(公告)号：US3299354A

公开(公告)日：1967-01-17

申请号：US20758262

申请日：1962-07-05

Applicant: COULTER ELECTRONICS

Inventor： HOGG WALTER R

IPC: G01N15/12

CPC classification number: G01N15/12

公开(公告)号：US3890568A

公开(公告)日：1975-06-17

申请号：US30412772

申请日：1972-11-06

Applicant: COULTER ELECTRONICS

Inventor： COULTER WALLACE H ,  HOGG WALTER R

IPC: G01N15/12 ,  G01N33/48 ,  G01N33/49 ,  G01N27/00

CPC classification number: G01N15/1227 ,  G01N2015/1075

Abstract: Particle sizing method and apparatus according to the teachings of the Coulter principle are improved for purposes of determining the length of long particles by measuring each particle-produced pulse at a specific percentage of its maximum amplitude, such as one-half maximum amplitude, and employing the duration at such specific amplitude percentage as a measure of particle length. Embodiments are provided for measuring particle populations in which the different long particles are assumed to possess: 1. THE SAME CROSS SECTIONS (PERPENDICULAR TO THE LONGITUDINAL AXIS): OR 2. RANDOMLY DIFFERENT CROSS SECTIONS; AND 3. IN WHICH THE DIFFERENT PARTICLES TRAVERSE THE SCANNING AMBIT WITH SPEEDS RELATED TO THEIR LENGTH.

Abstract translation: 改进了根据库尔特原理的教导的粒子尺寸方法和装置，用于通过以其最大幅度的特定百分比（例如二分之一最大幅度）测量每个粒子产生的脉冲来确定长颗粒的长度，并采用 持续时间在这样的特定幅度百分比作为粒子长度的度量。 提供了用于测量其中假定具有不同长粒子的粒子群的实施例：

公开(公告)号：US3859012A

公开(公告)日：1975-01-07

申请号：US27943672

申请日：1972-08-10

Applicant: COULTER ELECTRONICS

Inventor： HOGG WALTER R

IPC: G01N33/48 ,  G01N1/00 ,  G01N15/12 ,  F04B9/08

CPC classification number: G01N15/12

Abstract: A fluid ejecting mechanism for use in a study device wherein a non-diluted specific minute amount of fluid sample containing particles is ejected by the ejecting mechanism into a flow stream leading to a sensing zone in the particle counter. The ejecting mechanism includes a hollow body having a thermal expansion device mounted therein and a power supply circuit which supplies a predetermined amount of electrical energy to the thermal expansion device to raise the temperature of same a predetermined amount and cause the same to expand thereby to eject from the hollow body a specific amount of fluid sample having a volume displacement equal to the volume increase of the thermal expansion device. Preferably the hollow body is part of a syringe including a plunger. The syringe facilitates the picking up of fluid sample of which only a minute specific portion is ejected toward the sensing zone of the particle counter.

Abstract translation: 一种在研究装置中使用的流体喷射机构，其中将未稀释的特定微量的含有颗粒的流体样品通过喷射机构喷射到通向粒子计数器中的感测区域的流动流中。 排出机构包括其中安装有热膨胀装置的中空体和向热膨胀装置提供预定量的电能以提高预定量的温度并使其膨胀的电源电路，从而弹出 来自中空体的特定量的流体样品的体积位移等于热膨胀装置的体积增加。 优选地，中空体是包括柱塞的注射器的一部分。 注射器便于拾取流体样品，其中只有一分钟的特定部分朝向颗粒计数器的感测区域喷射。

公开(公告)号：US3689833A

公开(公告)日：1972-09-05

申请号：US3689833D

申请日：1971-06-29

Applicant: COULTER ELECTRONICS

Inventor： HOGG WALTER R

IPC: G01N15/12 ,  G01N27/08

CPC classification number: G01N15/12

Abstract: Electronic particle analyzing apparatus operating in accordance with the Coulter principle in which it is desired to isolate the aperture electrically from the electrolyte or suspending fluid flow system without breaking the flow of liquid. The metal-fluid interface normally provided by immersed electrodes is here provided by metallic conduit. The metallic conduit for the flowing particle-carrying medium is provided in the form of a helical coil having capacitive reactance means connected across the coil enabling the coil to act as an inductance and the combination to be tuned for any desired purpose. The principal purpose for such tuning is to achieve resonance, as for example, parallel resonance in which case the metallic conduit is frequency selective. In the case of parallel resonance, the metallic conduit presents high impedance to the flow of resultant electrical signals so as to isolate the aperture as stated. Other uses for resonance in metallic coils carrying liquid with suspended particles are described. In all cases the electric current is at high frequency.

Abstract translation: 电子粒子分析装置根据库尔特原理进行操作，其中期望将孔径与电解质或悬浮流体系统电隔离而不破坏液体流动。 通常由浸渍电极提供的金属 - 流体界面在这里由金属管道提供。 用于流动的颗粒承载介质的金属导管以螺旋线圈的形式提供，该螺旋线圈具有连接在线圈两端的电容性电抗装置，使得线圈能够充当电感，并且该组合被调谐以用于任何期望的目的。 这种调谐的主要目的是实现共振，例如并联谐振，在这种情况下，金属导管是频率选择性的。 在并联谐振的情况下，金属导管对所得电信号的流动呈现高阻抗，从而隔离所述的孔径。 描述了携带悬浮颗粒的液体的金属线圈中的共振的其它用途。 在所有情况下，电流处于高频。

公开(公告)号：US3389334A

公开(公告)日：1968-06-18

申请号：US38256064

申请日：1964-07-14

Applicant: COULTER ELECTRONICS

Inventor： COULTER WALLACE H ,  HOGG WALTER R

IPC: G01N15/12

CPC classification number: G01N15/12 ,  G01N15/1209

公开(公告)号：US3352280A

公开(公告)日：1967-11-14

申请号：US36423264

申请日：1964-05-01

Applicant: COULTER ELECTRONICS

Inventor： ROY HUGHES ,  HOGG WALTER R

IPC: G01N1/31

CPC classification number: G01N1/312

公开(公告)号：US3289916A

公开(公告)日：1966-12-06

申请号：US41153264

申请日：1964-11-16

Applicant: COULTER ELECTRONICS

Inventor： HOGG WALTER R ,  COOLEY KENNETH D

IPC: F04B13/00 ,  F04B27/04 ,  F04B43/04 ,  F04B45/00 ,  F04B45/027 ,  F04B49/02 ,  F04B49/16 ,  G01N15/00 ,  G01N15/12

CPC classification number: F04B45/027 ,  F04B27/04 ,  F04B29/00 ,  F04B49/16 ,  G01N15/12

公开(公告)号：US3902115A

公开(公告)日：1975-08-26

申请号：US40098673

申请日：1973-09-26

Applicant: COULTER ELECTRONICS

Inventor： HOGG WALTER R ,  COULTER WALLACE H ,  GINSBERG GUENTER ,  PRONI OSCAR ,  GODIN THOMAS J

IPC: G01N1/38 ,  G01N15/12 ,  G01N27/00

CPC classification number: G01N15/12 ,  G01N1/38 ,  G01N15/1218

Abstract: A two chamber aperture tube for obtaining signals from particles suspended in a fluid which passes through a scanning aperture. The suspension enters an aperture in an inlet chamber and passes thereafter to an outlet chamber in fluid connection with the inlet chamber. The inlet chamber of the tube is connected to a source of clean electrolyte; the outlet chamber is connected to a waste collecting container. A vacuum is applied to the collecting container to cause clean electrolyte to be drawn through the inlet chamber and wash behind the aperture simultaneously with passage of the suspension through the aperture. A restriction in the path of flow of the clean electrolyte causes the flow velocity thereof to increase behind the aperture and ensure that proper signals from all particles in the suspension are obtained.

公开(公告)号：US3882385A

公开(公告)日：1975-05-06

申请号：US43987574

申请日：1974-02-06

Applicant: COULTER ELECTRONICS

Inventor： COULTER WALLACE H ,  HOGG WALTER R

IPC: G01N15/12 ,  G06M11/00 ,  G01N27/00

CPC classification number: G01N15/12 ,  G01N15/1245

Abstract: An apparatus for studying particles of widely different sizes includes a vessel and a fluid medium in the vessel with the particles suspended thereon. First and second aperture tubes are suspended in the vessel at a first height, and a third aperture tube is suspended at a second lower height. The first aperture tube has an aperture of substantially smaller size than the second and third aperture tubes. The rate of entry through the aperture and into the second tube, of particles large enough to cause blockage of the first aperture in the first tube, is detected. When this rate drops below a first particular rate, indicating that substantially all particles greater than that size have settled below this particular height in the beaker, control circuitry is actuated to enable the fluid to enter into the first tube via the aperture therein for analyzing particles received therein via Coulter type detectors. Control circuitry may also be initiated to allow fluid to enter the third tube through its aperture for analyzing the particles received therein via Coulter type detectors.

Abstract translation: 用于研究不同尺寸的颗粒的装置包括在容器中的容器和流体介质，其中颗粒悬浮在其上。 第一和第二孔径管以第一高度悬挂在容器中，并且第三孔管以第二较低高度悬挂。 第一孔径管具有比第二和第三孔径管小得多的孔径。 检测通过孔径进入第二管的速度，其大小足以导致第一管中的第一孔阻塞。 当该速率降低到第一特定速率以下时，表明基本上所有大于该尺寸的颗粒已经沉降在烧杯中的该特定高度以下，控制电路被致动以使流体能够经由其中的孔进入第一管以分析颗粒 通过Coulter型探测器接收。

公开(公告)号：US3701029A

公开(公告)日：1972-10-24

申请号：US3701029D

申请日：1970-10-27

Applicant: COULTER ELECTRONICS

Inventor： HOGG WALTER R

IPC: G01N15/12 ,  H03K17/02 ,  H03K5/20

CPC classification number: G01N15/1227

Abstract: A sensor for use with apparatus operating in accordance with the principles of the Coulter electronic particle studying device, for differentiating between pulses produced by particles passing on axial or nearly axial paths through an aperture and pulses produced by particles passing off center. The pulse duration is measured at some fraction of the individual pulse amplitudes and only those which meet the criteria of duration established by the electronic circuitry are permitted to pass for use in pulse height analysis apparatus following the sensor. The other pulses are discarded on the basis of their greater durations. The apparatus of the invention provides structure for deriving a duration-measuring pulse whose duration is that of the particle pulse at its fractional amplitude, converting the signal into one which has an amplitude proportional to duration, and then subjecting the latter signal to the criteria of duration established as amplitude levels to operate gating means automatically for rejecting the longer duration pulses and passing the shorter duration pulses.

Abstract translation: 用于根据库尔特电子粒子研究装置的原理操作的装置的传感器，用于区分通过孔径的轴向或近似轴向通过的颗粒产生的脉冲和通过离开中心的粒子产生的脉冲。 在单个脉冲幅度的一些分数处测量脉冲持续时间，并且仅允许满足由电子电路建立的持续时间标准的脉冲持续时间通过以用于跟随传感器的脉冲高度分析装置。 其他脉冲基于它们更长的持续时间被丢弃。 本发明的装置提供用于导出持续时间测量脉冲的结构，其持续时间是粒子脉冲在其分数幅度的持续时间测量脉冲，将该信号转换成具有与持续时间成比例的幅度，然后将后一信号 持续时间建立为操作门控的幅度水平，自动意味着拒绝更长持续时间的脉冲并通过较短的持续时间脉冲。