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    CRYSTAL FORMING DEVICES AND SYSTEMS AND METHODS FOR MAKING AND USING THE SAME
    11.
    发明专利
    CRYSTAL FORMING DEVICES AND SYSTEMS AND METHODS FOR MAKING AND USING THE SAME 未知

    公开(公告)号：CA2554240A1

    公开(公告)日：2005-08-11

    申请号：CA2554240

    申请日：2005-01-25

    Applicant: FLUIDIGM CORP

    Inventor： PIEPRZYK MARTIN ,  KIMBALL JAKE ,  CHOU HOU-PU ,  UNGER MARC ,  LAM PHILLIP ,  GROSSMAN ROBERT

    IPC: G01N1/28 ,  B01J19/00 ,  B01L3/00 ,  B01L3/06 ,  B01L9/00 ,  B01L99/00 ,  B81B1/00 ,  B81B7/00 ,  C30B7/00 ,  C30B29/58 ,  G01N35/02 ,  G01N37/00

    Abstract: The present invention provides for microfluidic devices and methods for thei r use. The invention further provides for apparatus and systems for using the microfluidic devices, analyze reactions carried out in the microfluidic devices, and systems to generate, store, organize, and analyze data generate d from using the microfluidic devices. The invention further provides methods of using and making microfluidic systems and devices which, in some embodiments , are useful for crystal formation. In one embodiment, an apparatus includes a platen having a platen face with one or more fluid ports therein. The fluid ports spatially correspond to one or more wells on a surface of the microfluidic device. A platform for holding the microfluidic device relative to the platen is included, and a platen actuator for urging the platen again st the microfluidic device so that at least one of the fluid ports of the plate n is urged against one of the wells to form a pressure chamber comprising the well and the port, so that when pressurized fluid is introduced or removed into or from the pressure chamber through one of the ports, fluid pressure i s changed therein.

    METHODS, SYSTEMS, AND DEVICES FOR MULTIPLE SINGLE-CELL CAPTURING AND PROCESSING USING MICROFLUIDICS
    12.
    发明公开
    METHODS, SYSTEMS, AND DEVICES FOR MULTIPLE SINGLE-CELL CAPTURING AND PROCESSING USING MICROFLUIDICS 有权
    方法，系统和设备采集和处理几个单独的细胞的微流控芯片

    公开(公告)号：EP2820394A4

    公开(公告)日：2015-07-08

    申请号：EP13754093

    申请日：2013-02-28

    Applicant: FLUIDIGM CORP

    Inventor： FOWLER BRIAN ,  KIMBALL JAKE ,  MAUNG MYO THU ,  MAY ANDREW ,  NORRIS MICHAEL C ,  TOPPANI DOMINIQUE G ,  UNGER MARC A ,  WANG JING ,  WEST JASON A A

    IPC: G01N15/10

    CPC classification number: G01N1/28 ,  B01L3/502761 ,  B01L7/52 ,  B01L2200/0668 ,  B01L2300/0864 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/043 ,  B01L2400/0487 ,  B01L2400/086 ,  B01L2400/088 ,  C12P19/34 ,  C12Q1/6813 ,  C12Q1/6844 ,  C12Q1/686 ,  C12Q1/6869 ,  G01N1/34 ,  G01N15/1484 ,  C12Q2565/629

    Abstract: Methods, systems, and devices are described for multiple single-cell capturing and processing utilizing microfluidics. Tools and techniques are provided for capturing, partitioning, and/or manipulating individual cells from a larger population of cells along with generating genetic information and/or reactions related to each individual cell. Different capture configurations may be utilized to capture individual cells and then processing each individual cell in a multi-chamber reaction configuration. Some embodiments may provide for specific target amplification, whole genome amplification, whole transcriptome amplification, real-time PCR preparation, copy number variation, preamplification, mRNA sequencing, and/or haplotyping of the multiple individual cells that have been partitioned from the larger population of cells. Some embodiments may provide for other applications. Some embodiments may be configured for imaging the individual cells or associated reaction products as part of the processing. Reaction products may be harvested and/or further analyzed in some cases.

    Abstract translation: 方法，系统和装置被描述为多个单细胞捕获和处理利用微流体。 提供了用于捕获，分区和/或个体细胞从细胞中产生地连同遗传信息和/或与每个单独的电池反应的更大的人口操纵的工具和技术。 不同的捕获配置可以被用于捕获个人的细胞，然后在处理的多室反应配置每个单独的小区。 一些实施例可以提供特定目标扩增，全基因组扩增，全转录扩增，实时PCR制备，拷贝数变异，预扩增，测序mRNA和/或多个单独的电池单元型thathave是来自于较大的人口划分 细胞。 一些实施例可以提供用于其它应用。 一些实施例可以被配置为单个细胞或相关联的反应产物进行成像作为处理的一部分。 反应产物可以收获和/或在某些情况下，进一步的分析。

    METHODS, SYSTEMS, AND DEVICES FOR MULTIPLE SINGLE-CELL CAPTURING AND PROCESSING USING MICROFLUIDICS
    14.
    发明专利
    METHODS, SYSTEMS, AND DEVICES FOR MULTIPLE SINGLE-CELL CAPTURING AND PROCESSING USING MICROFLUIDICS 未知

    公开(公告)号：CA2878787A1

    公开(公告)日：2013-09-06

    申请号：CA2878787

    申请日：2013-02-28

    Applicant: FLUIDIGM CORP

    Inventor： FOWLER BRIAN ,  KIMBALL JAKE ,  MAUNG MYO THU ,  MAY ANDREW ,  NORRIS MICHAEL C ,  TOPPANI DOMINIQUE G ,  UNGER MARC A ,  WANG JING ,  WEST JASON A A

    IPC: G01N15/10

    Abstract: Methods, systems, and devices are described for multiple single-cell capturing and processing utilizing microfluidics. Tools and techniques are provided for capturing, partitioning, and/or manipulating individual cells from a larger population of cells along with generating genetic information and/or reactions related to each individual cell. Different capture configurations may be utilized to capture individual cells and then processing each individual cell in a multi-chamber reaction configuration. Some embodiments may provide for specific target amplification, whole genome amplification, whole transcriptome amplification, real-time PCR preparation, copy number variation, preamplification, mRNA sequencing, and/or haplotyping of the multiple individual cells that have been partitioned from the larger population of cells. Some embodiments may provide for other applications. Some embodiments may be configured for imaging the individual cells or associated reaction products as part of the processing. Reaction products may be harvested and/or further analyzed in some cases.

    Crystal forming devices and systems and methods for making and using the same
    15.
    发明专利
    Crystal forming devices and systems and methods for making and using the same 未知

    公开(公告)号：AU2010214783A1

    公开(公告)日：2010-09-23

    申请号：AU2010214783

    申请日：2010-09-02

    Applicant: FLUIDIGM CORP

    Inventor： GROSSMAN ROBERT ,  UNGER MARC ,  LAM PHILLIP ,  CHOU HOU-PU ,  KIMBALL JAKE ,  PIEPRZYK MARTIN

    IPC: G01N15/06 ,  B01J19/00 ,  B01L3/00 ,  B01L3/06 ,  B01L9/00 ,  B01L99/00 ,  C30B7/00 ,  C30B29/58 ,  G01N33/00 ,  G01N33/48

    Abstract: The present invention provides for microfluidic devices and methods for their use. The invention further provides for apparatus and systems for using the microfluidic devices, analyze reactions carried out in the microfluidic devices, and systems to generate, store, organize, and analyze data generated from using the microfluidic devices. The invention further provides methods of using and making microfluidic systems and devices which, in some embodiments, are useful for crystal formation. In one embodiment, an apparatus includes a platen having a platen face with one or more fluid ports therein. The fluid ports spatially correspond to one or more wells on a surface of the microfluidic device. A platform for holding the microfluidic device relative to the platen is included, and a platen actuator for urging the platen against the microfluidic device so that at least one of the fluid ports of the platen is urged against one of the wells to form a pressure chamber comprising the well and the port, so that when pressurized fluid is introduced or removed into or from the pressure chamber through one of the ports, fluid pressure is changed therein.

    Crystal forming devices and systems and methods for making and using the same
    16.
    发明专利
    Crystal forming devices and systems and methods for making and using the same 未知

    公开(公告)号：AU2005208879B2

    公开(公告)日：2010-06-03

    申请号：AU2005208879

    申请日：2005-01-25

    Applicant: FLUIDIGM CORP

    Inventor： CHOU HOU-PU ,  GROSSMAN ROBERT ,  LAM PHILLIP ,  KIMBALL JAKE ,  PIEPRZYK MARTIN ,  UNGER MARC

    IPC: G01N15/06 ,  B01J19/00 ,  B01L3/00 ,  B01L3/06 ,  B01L9/00 ,  B01L99/00 ,  C30B7/00 ,  C30B29/58 ,  G01N33/00 ,  G01N33/48

    Abstract: The present invention provides for microfluidic devices and methods for their use. The invention further provides for apparatus and systems for using the microfluidic devices, analyze reactions carried out in the microfluidic devices, and systems to generate, store, organize, and analyze data generated from using the microfluidic devices. The invention further provides methods of using and making microfluidic systems and devices which, in some embodiments, are useful for crystal formation. In one embodiment, an apparatus includes a platen having a platen face with one or more fluid ports therein. The fluid ports spatially correspond to one or more wells on a surface of the microfluidic device. A platform for holding the microfluidic device relative to the platen is included, and a platen actuator for urging the platen against the microfluidic device so that at least one of the fluid ports of the platen is urged against one of the wells to form a pressure chamber comprising the well and the port, so that when pressurized fluid is introduced or removed into or from the pressure chamber through one of the ports, fluid pressure is changed therein.

    CRYSTAL FORMING DEVICES AND SYSTEMS AND METHODS FOR MAKING AND USING THE SAME
    17.
    发明专利
    CRYSTAL FORMING DEVICES AND SYSTEMS AND METHODS FOR MAKING AND USING THE SAME 未知

    公开(公告)号：SG10202107927VA

    公开(公告)日：2021-08-30

    申请号：SG10202107927V

    申请日：2005-01-25

    Applicant: FLUIDIGM CORP

    Inventor： GROSSMAN ROBERT ,  UNGER MARC ,  LAM PHILLIP ,  CHOU HOU-PU ,  KIMBALL JAKE ,  PIEPRZYK MARTIN

    IPC: B01J19/00 ,  B01L3/00 ,  B01L3/06 ,  B01L9/00 ,  B01L99/00 ,  C30B7/00 ,  C30B29/58

    Abstract: The present invention provides for microfluidic devices and methods for their use. The invention further provides for apparatus and systems for using the microfluidic devices, analyze reactions carried out in the microfluidic devices, and systems to generate, store, organize, and analyze data generated from using the microfluidic devices. The invention further provides methods of using and making microfluidic systems and devices which, in some embodiments, are useful for crystal formation. In one embodiment, an apparatus includes a platen having a platen face with one or more fluid ports therein. The fluid ports spatially correspond to one or more wells on a surface of the microfluidic device. A platform for holding the microfluidic device relative to the platen is included, and a platen actuator for urging the platen against the microfluidic device so that at least one of the fluid ports of the platen is urged against one of the wells to form a pressure chamber comprising the well and the port, so that when pressurized fluid is introduced or removed into or from the pressure chamber through one of the ports, fluid pressure is changed therein.

    CRYSTAL FORMING DEVICES AND SYSTEMS AND METHODS FOR MAKING AND USING THE SAME
    18.
    发明专利
    CRYSTAL FORMING DEVICES AND SYSTEMS AND METHODS FOR MAKING AND USING THE SAME 未知

    公开(公告)号：SG187392A1

    公开(公告)日：2013-02-28

    申请号：SG2012094876

    申请日：2005-01-25

    Applicant: FLUIDIGM CORP

    Inventor： GROSSMAN ROBERT ,  UNGER MARC ,  LAM PHILLIP ,  CHOU HOU-PU ,  KIMBALL JAKE ,  PIEPRZYK MARTIN

    IPC: B01J19/00 ,  B01L3/00 ,  B01L3/06 ,  B01L9/00 ,  B01L99/00 ,  C30B7/00 ,  C30B29/58

    Abstract: The present invention provides for microfluidic devices and methods for their use. The invention further provides for apparatus and systems for using the microfluidic devices, analyze reactions carried out in the microfluidic devices, and systems to generate, store, organize, and analyze data generated from using the microfluidic devices. The invention further provides methods of using and making microfluidic systems and devices which, in some embodiments, are useful for crystal formation. In one embodiment, an apparatus includes a platen having a platen face with one or more fluid ports therein. The fluid ports spatially correspond to one or more wells on a surface of the microfluidic device. A platform for holding the microfluidic device relative to the platen is included, and a platen actuator for urging the platen against the microfluidic device so that at least one of the fluid ports of the platen is urged against one of the wells to form a pressure chamber comprising the well and the port, so that when pressurized fluid is introduced or removed into or from the pressure chamber through one o f the ports, fluid pressure is changed therein.FIG. 14B

    DISPOSITIVOS FORMADORES DE CRISTAL Y SISTEMAS Y METODOS PARA HACER Y UTILIZAR LOS MISMOS.
    19.
    发明专利
    DISPOSITIVOS FORMADORES DE CRISTAL Y SISTEMAS Y METODOS PARA HACER Y UTILIZAR LOS MISMOS. 未知

    公开(公告)号：MXPA06008399A

    公开(公告)日：2008-03-07

    申请号：MXPA06008399

    申请日：2005-01-25

    Applicant: FLUIDIGM CORP

    Inventor： GROSSMAN ROBERT ,  UNGER MARC ,  LAM PHILLIP ,  CHOU HOU-PU ,  KIMBALL JAKE ,  PIERPRZYK MARTIN

    IPC: G01N33/00 ,  B01J19/00 ,  B01L3/00 ,  B01L3/06 ,  B01L9/00 ,  B01L99/00 ,  C30B7/00 ,  C30B29/58

    Abstract: La presente invencion proporciona dispositivos de microfluido y metodos para su uso. La invencion ademas proporciona aparatos y sistemas para usar los dispositivos de microfluido, analizar reacciones realizadas en los dispositivos de microfluido, y sistemas para generar, almacenar, organizar, y analizar datos generados del uso de los dispositivos de microfluido. La invencion ademas proporciona metodos para usar y hacer sistemas y dispositivos de microfluido que, en algunas modalidades, son utiles para la formacion de cristal. En una modalidad, un aparato incluye una platina que tiene una cara de platina con uno o mas puertos de fluido en la misma. Los puertos de fluido espacialmente corresponden a uno o mas pozos sobre una superficie del dispositivo de microfluido. Se incluye una plataforma para sostener el dispositivo de microfluido con relacion a la platina, y un accionador de platina para empujar la platina contra el dispositivo de microfluido de manera que por lo menos uno de los puertos de fluido de la platina es empujado contra uno de los pozos para formar una camara de presion que comprende el pozo y el puerto, de manera que ciando se introduce o remueve fluido presurizado hacia o desde la camara de presion a traves de uno de los puertos, la presion de fluido es cambiada ahi.

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