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公开(公告)号：ZA916097B
公开(公告)日：1992-04-29
申请号：ZA916097
申请日：1991-08-02
Applicant: HOECHST AG
Inventor： KONIG WOLFGANG , WOLFGANG KONIG , SANDOW JURGEN , JURGEN SANDOW , KOLAR CENEK , CENEK KOLAR
Abstract: Peptides of the formula in which X is alkanoyl, A is optionally substituted D-Na(2), D-Phe or D-Trp, B is optionally substituted D-Phe, C is D-Pal(3) or optionally substituted D-Phe or D-Trp, and D is Tyr or His, E is D-Ser(R ), F is Leu, Trp or Phe, G is L-Ser(R ), H is Gly-NH2, D-Ala-NH2 or azagly-NH2 and R is a glycosyl radical, have inhibitory effects on the formation of the gonadotropins lutropin and follitropin and thus also on the synthesis of testosterone and oestrogen. A process for the preparation of these peptides is described.
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公开(公告)号：NO913020A
公开(公告)日：1992-02-05
申请号：NO913020
申请日：1991-08-02
Applicant: HOECHST AG
Inventor： KOENIG WOLFGANG , SANDOW JUERGEN , KOLAR CENEK
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公开(公告)号：NZ231716A
公开(公告)日：1991-12-23
申请号：NZ23171689
申请日：1989-12-12
Applicant: HOECHST AG
Inventor： KOLAR CENEK , KONIG WOLFGANG , SANDOW JURGEN KURT
Abstract: Peptides of the formula Ac-D-Nal(2)-D-Phe-D-Phe-Ser-X-D-Ser(Rha)-Leu-Arg-Pro-Y in which X represents Tyr or His and Y represents Gly-NH2, D-Ala-NH2, Azgly-NH2 or NH-C2H5 are competitive antagonists of Gn-RH. They are used for the treatment of gonadotropin- and steroid-dependent diseases and are prepared by known methods of peptide chemistry.
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公开(公告)号：CA2005420A1
公开(公告)日：1990-06-14
申请号：CA2005420
申请日：1989-12-13
Applicant: HOECHST AG
Inventor： KOLAR CENEK , KONIG WOLFGANG , SANDOW JURGEN K
Abstract: Peptides of the formula Ac-D-Nal(2)-D-Phe-D-Phe-Ser-X-D-Ser(Rha)-Leu-Arg-Pro-Y in which X represents Tyr or His and Y represents Gly-NH2, D-Ala-NH2, Azgly-NH2 or NH-C2H5 are competitive antagonists of Gn-RH. They are used for the treatment of gonadotropin- and steroid-dependent diseases and are prepared by known methods of peptide chemistry.
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公开(公告)号：PT85881A
公开(公告)日：1987-11-01
申请号：PT8588187
申请日：1987-10-08
Applicant: HOECHST AG
Inventor： SANDOW JURGEN KURT , KOLAR CENEK , KONIG WOLFGANG
IPC: A61K38/00 , A61K38/04 , A61P5/00 , A61P9/12 , C07K7/06 , C07K7/23 , C07K9/00 , C07K14/575 , A61K37/02
Abstract: The invention relates to peptides of the formula in which X is absent or is hydrogen or acyl; A is Pgl, de-hydro-Pro, Pro, D-Thi or D-Pgl or represents optionally substituted D-Nal(2), D-Phe or D-Trp; B is His or optionally substituted D-Phe; C is Trp, D-Thi, D-Pal(3) or optionally substituted D-Trp; D is Tyr, Arg of His; E is D-Ser(R1), beta -Asn, beta -Asp-OMe, D-Thi or -NH-CH(CH2R2)-CO-; F is Ser(R1), Leu, Trp or Phe; G is Gly-NH2, Aza-Gly-NH2, D-Ala-NH2 or NH-alkyl; R1 is glycosyl and R2 is hydrogen, acyl, aryl or heteroaryl. The invention also relates to methods for the preparation of these peptides, agents containing them and their use.
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Patent Agency Ranking
公开(公告)号：FI874401A0
公开(公告)日：1987-10-07
申请号：FI874401
申请日：1987-10-07
Applicant: HOECHST AG
Inventor： KOENIG WOLFGNG , SANDOW JUERGEN KURT , KOLAR CENEK
IPC: A61K38/00 , A61K38/04 , A61P5/00 , A61P9/12 , C07K7/06 , C07K7/23 , C07K9/00 , C07K14/575 , C07K
Abstract: The invention relates to peptides of the formula in which X is absent or is hydrogen or acyl; A is Pgl, de-hydro-Pro, Pro, D-Thi or D-Pgl or represents optionally substituted D-Nal(2), D-Phe or D-Trp; B is His or optionally substituted D-Phe; C is Trp, D-Thi, D-Pal(3) or optionally substituted D-Trp; D is Tyr, Arg of His; E is D-Ser(R1), beta -Asn, beta -Asp-OMe, D-Thi or -NH-CH(CH2R2)-CO-; F is Ser(R1), Leu, Trp or Phe; G is Gly-NH2, Aza-Gly-NH2, D-Ala-NH2 or NH-alkyl; R1 is glycosyl and R2 is hydrogen, acyl, aryl or heteroaryl. The invention also relates to methods for the preparation of these peptides, agents containing them and their use.
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公开(公告)号：DK295885D0
公开(公告)日：1985-06-28
申请号：DK295885
申请日：1985-06-28
Applicant: HOECHST AG
Inventor： THIEM JOACHIM , DEGER HANS-MATTHIAS , KOLAR CENEK , KREUZER MATTHIAS
Abstract: 1-Azidoaldoses are obtained by reacting 1-fluoroaldoses with metal azides in polar, water-miscible, preferably water-containing, solvents. The hydroxyl groups do not react at the same time, so that they need not be protected or can be present in a derivatized form.
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公开(公告)号：NO309429B1
公开(公告)日：2001-01-29
申请号：NO913020
申请日：1991-08-02
Applicant: HOECHST AG
Inventor： KOENIG WOLFGANG , SANDOW JUERGEN , KOLAR CENEK
IPC: A61K38/00 , A61P5/00 , A61P5/24 , C07K7/06 , C07K7/23 , C07K9/00 , C07K14/575 , C07K14/475
Abstract: Peptides of the formula in which X is alkanoyl, A is optionally substituted D-Na(2), D-Phe or D-Trp, B is optionally substituted D-Phe, C is D-Pal(3) or optionally substituted D-Phe or D-Trp, and D is Tyr or His, E is D-Ser(R ), F is Leu, Trp or Phe, G is L-Ser(R ), H is Gly-NH2, D-Ala-NH2 or azagly-NH2 and R is a glycosyl radical, have inhibitory effects on the formation of the gonadotropins lutropin and follitropin and thus also on the synthesis of testosterone and oestrogen. A process for the preparation of these peptides is described.
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公开(公告)号：PT501215E
公开(公告)日：2000-10-31
申请号：PT92102197
申请日：1992-02-10
Applicant: HOECHST AG
Inventor： SEEMANN GERHARD , BOSSLET KLAUS , CZECH JORG , KOLAR CENEK , HOFFMANN DIETER , SEDLACEK HANS-HARALD
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公开(公告)号：DE59209839D1
公开(公告)日：2000-06-29
申请号：DE59209839
申请日：1992-02-10
Applicant: HOECHST AG
Inventor： SEEMANN GERHARD , BOSSLET KLAUS , CZECH JOERG , KOLAR CENEK , HOFFMANN DIETER , SEDLACEK HANS-HARALD
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