公开(公告)号：ES2086341T3

公开(公告)日：1996-07-01

申请号：ES90117400

申请日：1990-09-10

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  HENNING RAINER DR ,  LINZ WOLFGANG DR ,  NICKEL WOLF-ULRICH DR ,  RUPPERT DIETER DR ,  URBACH HANSJORG DR

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61P9/12 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07K5/02

Abstract: The invention relates to renin-inhibiting amino-acid derivatives of the formula in which R is a radical of a substituted nitrogen-containing heterocycle such as piperidine, X is CO, CS, SO2 or SO, Y is CH2, O or S, B is the residue of an amino acid of the formula H-B-OH, and R , R and R are as defined in the description, process for their preparation, agents containing them and their use.

公开(公告)号：GR3019331T3

公开(公告)日：1996-06-30

申请号：GR960400719

申请日：1996-03-15

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  HENNING RAINER DR ,  LINZ WOLFGANG DR ,  NICKEL WOLF-ULRICH DR ,  RUPPERT DIETER DR ,  URBACH HANSJOERG DR

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61P9/12 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07K5/02

Abstract: The invention relates to renin-inhibiting amino-acid derivatives of the formula in which R is a radical of a substituted nitrogen-containing heterocycle such as piperidine, X is CO, CS, SO2 or SO, Y is CH2, O or S, B is the residue of an amino acid of the formula H-B-OH, and R , R and R are as defined in the description, process for their preparation, agents containing them and their use.

公开(公告)号：AT135368T

公开(公告)日：1996-03-15

申请号：AT90117400

申请日：1990-09-10

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  HENNING RAINER DR ,  LINZ WOLFGANG DR ,  NICKEL WOLF-ULRICH DR ,  RUPPERT DIETER DR ,  URBACH HANSJOERG DR

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61P9/12 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07K5/02

Abstract: The invention relates to renin-inhibiting amino-acid derivatives of the formula in which R is a radical of a substituted nitrogen-containing heterocycle such as piperidine, X is CO, CS, SO2 or SO, Y is CH2, O or S, B is the residue of an amino acid of the formula H-B-OH, and R , R and R are as defined in the description, process for their preparation, agents containing them and their use.

公开(公告)号：ES2062214T3

公开(公告)日：1994-12-16

申请号：ES90113712

申请日：1990-07-18

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  URBACH HANSJORG DR ,  WAGNER ADALBERT DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR ,  KRAMER WERNER DR DR

IPC: C12N9/99 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/445 ,  A61K31/535 ,  A61K38/55 ,  A61P9/12 ,  C07C237/08 ,  C07C237/22 ,  C07D211/26 ,  C07D211/58 ,  C07D233/54 ,  C07D233/64 ,  C07D295/20 ,  C07D333/24 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D521/00 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K5/078 ,  C07K14/81 ,  A61K37/64

Abstract: The present invention relates to compounds of the formula I in which A, R , R , R and n are defined as indicated in the description, to processes for the preparation thereof, to the use thereof as medicines and to pharmaceutical compositions containing these.

公开(公告)号：ES2054989T3

公开(公告)日：1994-08-16

申请号：ES89121499

申请日：1989-11-21

Applicant: HOECHST AG

Inventor： HENNING RAINER DR ,  URBACH HANSJORG DR ,  RUPPERT DIETER DR ,  SCHOLKENS BERNWARD DR

IPC: C07D213/40 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/4433 ,  A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  C07D233/64 ,  C07D401/12 ,  C07D409/12 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  A61K37/64

Abstract: The invention relates to compounds of the formula I in which A is a radical of the formula II in which E is a CH2 group or a radical NR , G is a radical from the group comprising S, SO, SO2, O, CO, CS or a direct bond, B is an amino acid, D is a heterocycle, and R , R , R , R , R , R and R are defined in the description, and the salts thereof. The invention also relates to a process for preparing the compounds of the formula I and to the use thereof as medicines.

公开(公告)号：AT93863T

公开(公告)日：1993-09-15

申请号：AT89122794

申请日：1989-12-11

Applicant: HOECHST AG

Inventor： RUEGER WOLFGANG DR ,  URBACH HANSJOERG DR ,  RUPPERT DIETER DR ,  SCHOELKENS BERNWARD DR

IPC: A61K31/16 ,  A61K31/33 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4412 ,  A61K31/4418 ,  A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  A61P31/12 ,  A61P43/00 ,  C07C291/02 ,  C07D213/81 ,  C07D233/64 ,  C07D295/18 ,  C07D333/24 ,  C07D521/00 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  A61K37/64

公开(公告)号：BR9202327A

公开(公告)日：1993-01-19

申请号：BR9202327

申请日：1992-06-19

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  HENNING RAINER DR ,  URBACH HANSJOERG DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR

IPC: A61K31/495 ,  A61P9/12 ,  A61P43/00 ,  C07D241/10 ,  C07D249/08 ,  C07D401/04 ,  C07D487/04 ,  C07D519/00 ,  C07D487/02 ,  A61K31/395

Abstract: Heterocyclic compounds of the formula (I) in which the radicals have the following meanings: R is, for example, propyl or isobutyl, R is, for example, phenyl or pyridyl, R is, for example, hydrogen, R is, for example, cyclohexylmethyl, R is, for example, hydrogen or hydroxyl, R is, for example, a radical of the formula (II> (CH2)5-CHR -Z (II> where R is, for example, hydrogen, Z represents a 5- to 7-membered heterocyclic ring and s denotes 0, 1, 2, 3 or 4; are potent renin-inhibiting compounds.

公开(公告)号：CZ9201906A3

公开(公告)日：1993-01-13

申请号：CS190692

申请日：1992-06-19

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  HENNING RAINER DR ,  URBACH HANSJORG DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR

IPC: A61K31/33 ,  A61K31/415 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P9/00 ,  A61P9/12 ,  A61P31/12 ,  A61P43/00 ,  C07D213/30 ,  C07D213/40 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

CPC classification number: C07D213/30 ,  C07D401/12 ,  C07D401/14 ,  C07D417/14

公开(公告)号：CZ9201879A3

公开(公告)日：1993-01-13

申请号：CS187992

申请日：1992-06-18

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  HENNING RAINER DR ,  URBACH HANSJORG DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR

IPC: A61K31/495 ,  A61P9/12 ,  A61P43/00 ,  C07D241/10 ,  C07D249/08 ,  C07D401/04 ,  C07D487/04 ,  C07D519/00

CPC classification number: C07D487/04

公开(公告)号：CS368890A3

公开(公告)日：1992-02-19

申请号：CS368890

申请日：1990-07-24

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  URBACH HANSJORG DR ,  WAGNER ADALBERT DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR ,  KRAMES WERNER DR

IPC: C12N9/99 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/445 ,  A61K31/535 ,  A61K38/55 ,  A61P9/12 ,  C07C237/08 ,  C07C237/22 ,  C07D211/26 ,  C07D211/58 ,  C07D233/54 ,  C07D233/64 ,  C07D295/20 ,  C07D333/24 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D521/00 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K5/078 ,  C07K14/81

Abstract: The present invention relates to compounds of the formula I in which A, R , R , R and n are defined as indicated in the description, to processes for the preparation thereof, to the use thereof as medicines and to pharmaceutical compositions containing these.