公开(公告)号：CZ9701547A3

公开(公告)日：1997-12-17

申请号：CZ154797

申请日：1997-05-20

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  HEITSCH HOLGER DR ,  NOLKEN GERHARD DR ,  WIRTH KLAUS DR ,  SCHOLKENS BERNWARD PROF DR

IPC: C07D277/60 ,  A61K31/38 ,  A61K31/395 ,  A61K31/41 ,  A61K31/425 ,  A61K31/428 ,  A61K31/53 ,  A61P43/00 ,  C07D253/10 ,  C07D277/64 ,  C07D277/66 ,  C07D277/68 ,  C07D277/70 ,  C07D277/74 ,  C07D277/82 ,  C07D417/12

CPC classification number: C07D417/12 ,  C07D277/64

公开(公告)号：CZ81097A3

公开(公告)日：1997-10-15

申请号：CZ81097

申请日：1997-03-17

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  HEITSCH HOLGER DR ,  NOLKEN GERHARD DR ,  WIRTH KLAUS DR ,  SCHOLKENS BERNWARD PROF DR

IPC: C07D237/28 ,  A61K31/345 ,  A61K31/47 ,  A61K31/495 ,  A61K31/53 ,  A61P43/00 ,  C07D215/04 ,  C07D215/26 ,  C07D239/72 ,  C07D239/74 ,  C07D241/36 ,  C07D241/44 ,  C07D253/04 ,  C07D253/065 ,  C07D257/10

Abstract: Fluoroalkyl- and fluoroalkoxy-substituted benzyloxy-azaheterocyclic compounds of formula (I) and their salts are new: X1-X3 = N or CR ; R , R = H or halo; R , R = H, halo, 1-5C alkyl or 2-5C alkenyl; R = 2-5C alkenediyl, halo, OR , SR , NHR , -COOR or COOH; 1-6C alkyl, 6-12C aryl or 6-12C aryl-1-3C alkyl (all optionally substituted by e.g. OR , SR , NO2, CN, NHR or halo); R , R = H, 1-5C alkyl, 3-5C alkenyl or 6-12C aryl-1-3C alkyl; R = 1-5C alkyl or 1-5C alkoxy (both substituted by 1 or more F or Cl); B = amino acid; D = 2-5C alkanediyl, 1-5C alkanediyl or -(CH2)n-Yp-(CH2)m-; E = O or S; Y = O, S or NR ; n, m = 0-3; o = 1-3; and p = 0 or 1.

公开(公告)号：ID16274A

公开(公告)日：1997-09-18

申请号：ID970863

申请日：1997-03-17

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  HEITSCH HOLGER DR ,  NOLKEN GERHARD DR ,  WIRTH KLAUS DR ,  SCHOLKENS BERNWARD PROF DR

IPC: C07D237/28 ,  A61K31/345 ,  A61K31/47 ,  A61K31/495 ,  A61K31/53 ,  A61P43/00 ,  C07D215/04 ,  C07D215/26 ,  C07D239/72 ,  C07D239/74 ,  C07D241/36 ,  C07D241/44 ,  C07D253/04 ,  C07D253/065 ,  C07D257/10 ,  C07D257/00

Abstract: Fluoroalkyl- and fluoroalkoxy-substituted benzyloxy-azaheterocyclic compounds of formula (I) and their salts are new: X1-X3 = N or CR ; R , R = H or halo; R , R = H, halo, 1-5C alkyl or 2-5C alkenyl; R = 2-5C alkenediyl, halo, OR , SR , NHR , -COOR or COOH; 1-6C alkyl, 6-12C aryl or 6-12C aryl-1-3C alkyl (all optionally substituted by e.g. OR , SR , NO2, CN, NHR or halo); R , R = H, 1-5C alkyl, 3-5C alkenyl or 6-12C aryl-1-3C alkyl; R = 1-5C alkyl or 1-5C alkoxy (both substituted by 1 or more F or Cl); B = amino acid; D = 2-5C alkanediyl, 1-5C alkanediyl or -(CH2)n-Yp-(CH2)m-; E = O or S; Y = O, S or NR ; n, m = 0-3; o = 1-3; and p = 0 or 1.

公开(公告)号：CZ281983B6

公开(公告)日：1997-04-16

申请号：CS381192

申请日：1992-12-21

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  HENNING RAINER DR ,  WAGNER ADALBERT DR ,  GERHARDS HERMANN DR ,  BECKER REINHARD DR ,  SCHOLKENS BERNWARD PROF DR

IPC: A61K31/415 ,  A61K31/4164 ,  A61K31/64 ,  A61P9/10 ,  A61P9/12 ,  C07D233/84 ,  C07D233/86 ,  C07D233/90

Abstract: Compounds of the formula (I) in which R is, for example, ethyl, R is, for example, methyl, n is, for example, zero, R is, for example, COOH and R is, for example, SO2NHCONHCH3 are highly active antagonists of angiotensin II receptors.

公开(公告)号：ES2092737T3

公开(公告)日：1996-12-01

申请号：ES93116788

申请日：1993-10-18

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  KLEEMANN HEINZ-WERNER DR ,  REGNAT DIETER DR ,  KLEINER HANS-JERG DR

IPC: C07B39/00 ,  C07C17/14 ,  C07C22/04 ,  C07C67/307 ,  C07C67/343 ,  C07C69/65 ,  C07C69/76 ,  C07C205/12 ,  C07C255/50 ,  C07C257/12 ,  C07C257/20 ,  C07C311/05 ,  C07C311/18 ,  C07C311/53 ,  C07D275/04 ,  C07D275/06 ,  C07D333/24 ,  C07D333/60 ,  C07D333/68 ,  C07D333/70 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

Abstract: Aromatic bromomethyl compounds play an important role in the synthesis of active substances. They can be obtained in particularly high purity by free-radical bromination of aromatic methyl compounds in the solvent chlorobenzene.

公开(公告)号：DE59004292D1

公开(公告)日：1994-03-03

申请号：DE59004292

申请日：1990-07-18

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  URBACH HANSJOERG DR ,  WAGNER ADALBERT DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR ,  KRAMER WERNER DR DR

IPC: C12N9/99 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/445 ,  A61K31/535 ,  A61K38/55 ,  A61P9/12 ,  C07C237/08 ,  C07C237/22 ,  C07D211/26 ,  C07D211/58 ,  C07D233/54 ,  C07D233/64 ,  C07D295/20 ,  C07D333/24 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D521/00 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K5/078 ,  C07K14/81 ,  A61K37/64

Abstract: The present invention relates to compounds of the formula I in which A, R , R , R and n are defined as indicated in the description, to processes for the preparation thereof, to the use thereof as medicines and to pharmaceutical compositions containing these.

公开(公告)号：CS354591A3

公开(公告)日：1992-06-17

申请号：CS354591

申请日：1991-11-22

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  HENNING RAINER DR ,  NICKEL WOLF-ULRICH DR

IPC: A61K31/41 ,  A61K31/425 ,  A61P9/12 ,  A61P43/00 ,  C07D263/06 ,  C07D417/04 ,  C07D417/06 ,  C12N9/99 ,  C07D263/04 ,  A61K31/42

Abstract: The invention relates to compounds of the formula in which W represents -CO-, -O-CO-, -SO2- or -NH-CO-, R , R , R , R , R and R represent hydrogen or an organic radical and R denotes alkyl, cycloalkyl or cycloalkylalkyl, processes for their preparation, intermediates and their use in the preparation of inhibitors of renin and HIV protease.

公开(公告)号：DE4037437A1

公开(公告)日：1992-05-27

申请号：DE4037437

申请日：1990-11-24

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  HENNING RAINER DR ,  NICKEL WOLF-ULRICH DR

IPC: A61K31/41 ,  A61K31/425 ,  A61P9/12 ,  A61P43/00 ,  C07D263/06 ,  C07D417/04 ,  C07D417/06 ,  C12N9/99

Abstract: The invention relates to compounds of the formula in which W represents -CO-, -O-CO-, -SO2- or -NH-CO-, R , R , R , R , R and R represent hydrogen or an organic radical and R denotes alkyl, cycloalkyl or cycloalkylalkyl, processes for their preparation, intermediates and their use in the preparation of inhibitors of renin and HIV protease.

公开(公告)号：CS198090A2

公开(公告)日：1991-08-13

申请号：CS198090

申请日：1990-04-20

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  URBACH HANSJORG DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR ,  SCHOLKENS BERNWARD PROF DR

IPC: A61K38/55 ,  A61K38/00 ,  A61P9/00 ,  A61P9/12 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  C07K5/08

Abstract: The present invention relates to compounds of the formula I in which A and B are, independently of one another, an amino acid, and R , R , R and R are as defined in the description, to processes for the preparation thereof, to their use as medicines and to pharmaceutical agents containing them.

公开(公告)号：SI0796848T1

公开(公告)日：2003-12-31

申请号：SI9730572

申请日：1997-03-05

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  HEITSCH HOLGER DR ,  NOELKNE GERHARD DR ,  WIRTH KLAUS DR ,  BERNARD PROF-DR

IPC: C07D237/28 ,  A61K31/345 ,  A61K31/47 ,  A61K31/495 ,  A61K31/53 ,  A61P43/00 ,  C07D215/04 ,  C07D215/26 ,  C07D239/72 ,  C07D239/74 ,  C07D241/36 ,  C07D241/44 ,  C07D253/04 ,  C07D253/065 ,  C07D257/10

Abstract: Fluoroalkyl- and fluoroalkoxy-substituted benzyloxy-azaheterocyclic compounds of formula (I) and their salts are new: X1-X3 = N or CR ; R , R = H or halo; R , R = H, halo, 1-5C alkyl or 2-5C alkenyl; R = 2-5C alkenediyl, halo, OR , SR , NHR , -COOR or COOH; 1-6C alkyl, 6-12C aryl or 6-12C aryl-1-3C alkyl (all optionally substituted by e.g. OR , SR , NO2, CN, NHR or halo); R , R = H, 1-5C alkyl, 3-5C alkenyl or 6-12C aryl-1-3C alkyl; R = 1-5C alkyl or 1-5C alkoxy (both substituted by 1 or more F or Cl); B = amino acid; D = 2-5C alkanediyl, 1-5C alkanediyl or -(CH2)n-Yp-(CH2)m-; E = O or S; Y = O, S or NR ; n, m = 0-3; o = 1-3; and p = 0 or 1.