公开(公告)号：NZ234836A

公开(公告)日：1997-05-26

申请号：NZ23483690

申请日：1990-08-09

Applicant: HOECHST AG

Inventor： LINZ WOLFGANG ,  SCHOLKENS BERNWARD ,  SCHOLZ WOLFGANG ,  WIEMER GABRIELE ,  URBACH HANSJORG ,  HENNING RAINER ,  TEETZ VOLKER

IPC: A61K38/55 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07C237/12 ,  C07K5/06 ,  A61K38/05 ,  A61K31/40 ,  A61K31/47

Abstract: The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and hyperplasia by administration of angiotensin converting enzyme inhibitors. Administration of compounds of the formula I (I) in which n is 1 or 2, R, R1, R2 and R3 are identical or different and each is hydrogen or an organic radical, and R4 and R5 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, is preferred. The invention additionally relates to angiotensin converting enzyme inhibitors and to agents containing these for administration for the treatment of the abovementioned diseases.

公开(公告)号：IE64604B1

公开(公告)日：1995-08-23

申请号：IE291090

申请日：1990-08-10

Applicant: HOECHST AG

Inventor： LINZ WOLFGANG ,  SCHOELKENS BERNWARD ,  SCHOLZ WOLFGANG ,  WIEMER GABRIELE ,  URBACH HANSJOERG ,  HENNING RAINER ,  TEETZ VOLKER

IPC: A61K38/55 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07C237/12 ,  C07K5/06 ,  A61K37/02 ,  A61K37/64

Abstract: The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and hyperplasia by administration of angiotensin converting enzyme inhibitors. Administration of compounds of the formula I (I) in which n is 1 or 2, R, R1, R2 and R3 are identical or different and each is hydrogen or an organic radical, and R4 and R5 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, is preferred. The invention additionally relates to angiotensin converting enzyme inhibitors and to agents containing these for administration for the treatment of the abovementioned diseases.

公开(公告)号：AU4163793A

公开(公告)日：1994-01-06

申请号：AU4163793

申请日：1993-06-30

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  WIEMER GABRIELE ,  WAGNER ADALBERT ,  KLEEMANN HEINZ-WERNER

IPC: A61K31/40 ,  A61K31/00 ,  A61K31/41 ,  A61K31/415 ,  A61K31/435 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61K45/00 ,  A61P9/08 ,  A61P9/10 ,  A61P25/28 ,  A61P37/00 ,  C07D207/32 ,  C07D233/84 ,  C07D233/90 ,  C07D255/02 ,  C07D257/04 ,  C07D403/10 ,  C07D471/04

公开(公告)号：IE902910A1

公开(公告)日：1991-02-27

申请号：IE291090

申请日：1990-08-10

Applicant: HOECHST AG

Inventor： LINZ WOLFGANG ,  SCHOELKENS BERNWARD ,  SCHOLZ WOLFGANG ,  WIEMER GABRIELE ,  URBACH HANSJOERG ,  HENNING RAINER ,  TEETZ VOLKER

IPC: A61K38/55 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07C237/12 ,  C07K5/06 ,  A61K37/02 ,  A61K37/64

Abstract: The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and hyperplasia by administration of angiotensin converting enzyme inhibitors. Administration of compounds of the formula I (I) in which n is 1 or 2, R, R1, R2 and R3 are identical or different and each is hydrogen or an organic radical, and R4 and R5 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, is preferred. The invention additionally relates to angiotensin converting enzyme inhibitors and to agents containing these for administration for the treatment of the abovementioned diseases.

公开(公告)号：NO903532L

公开(公告)日：1991-02-12

申请号：NO903532

申请日：1990-08-10

Applicant: HOECHST AG

Inventor： LINZ WOLFGANG ,  SCHOELKENS BERNWARD ,  SCHOLZ WOLFGANG ,  WIEMER GABRIELE ,  URBACH HANSJOERG ,  HENNING RAINER ,  TEETZ VOLKER

IPC: A61K38/55 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07C237/12 ,  C07K5/06 ,  A61K37/64 ,  A61K37/02

Abstract: The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and hyperplasia by administration of angiotensin converting enzyme inhibitors. Administration of compounds of the formula I (I) in which n is 1 or 2, R, R1, R2 and R3 are identical or different and each is hydrogen or an organic radical, and R4 and R5 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, is preferred. The invention additionally relates to angiotensin converting enzyme inhibitors and to agents containing these for administration for the treatment of the abovementioned diseases.

公开(公告)号：CA2023089A1

公开(公告)日：1991-02-12

申请号：CA2023089

申请日：1990-08-10

Applicant: HOECHST AG

Inventor： LINZ WOLFGANG ,  SCHOLKENS BERNWARD ,  SCHOLZ WOLFGANG ,  WIEMER GABRIELE ,  URBACH HANSJORG ,  HENNING RAINER ,  TEETZ VOLKER

IPC: A61K38/55 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07C237/12 ,  C07K5/06 ,  A61K38/05

Abstract: The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and hyperplasia by administration of angiotensin converting enzyme inhibit- ors. Administration of compounds of the formula I (see formula I) in which n is 1 or 2, R, R1, R2 and R3 are identical or different and each is hydrogen or an organic radical, and R4 and R5 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, is preferred. The invention additionally relates to angio- tensin converting enzyme inhibitors and to agents con- taining these for administration for the treatment of the abovementioned diseases.

公开(公告)号：FI903936A0

公开(公告)日：1990-08-09

申请号：FI903936

申请日：1990-08-09

Applicant: HOECHST AG

Inventor： LINZ WOLFGANG ,  SCHOELKENS BERNWARD ,  SCHOLZ WOLFGANG ,  WIEMER GABRIELE ,  URBACH HANSJOERG ,  HENNING RAINER ,  TEETZ VOLKER

IPC: A61K38/55 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07C237/12 ,  C07K5/06 ,  A61K

Abstract: The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and hyperplasia by administration of angiotensin converting enzyme inhibitors. Administration of compounds of the formula I (I) in which n is 1 or 2, R, R1, R2 and R3 are identical or different and each is hydrogen or an organic radical, and R4 and R5 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, is preferred. The invention additionally relates to angiotensin converting enzyme inhibitors and to agents containing these for administration for the treatment of the abovementioned diseases.

公开(公告)号：ZA896717B

公开(公告)日：1990-05-30

申请号：ZA896717

申请日：1989-09-01

Applicant: HOECHST AG

Inventor： NICKEL WOLF-ULRICH ,  WOLF-ULRICH NICKEL ,  HENNING RAINER ,  RAINER HENNING ,  RUEGER WOLFGANG ,  WOLFGANG RUEGER ,  LERCH ULRICH ,  ULRICH LERCH ,  URBACH HANSJOERG ,  HANSJOERG URBACH ,  HOCK FRANZ ,  FRANZ HOCK ,  WIEMER GABRIELE ,  GABRIELE WIEMER

IPC: A61K31/495 ,  A61P25/00 ,  A61P25/28 ,  C07D241/08 ,  C07D403/04 ,  C07D405/04 ,  C07D455/04 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D513/04 ,  C07K1/113 ,  C07K5/06 ,  C07D ,  C07K ,  A61K

Abstract: The invention relates to compounds of the formula I (I) in which R1, R2 and R4 represent optionally substituted aliphatic, alicyclic, alicyclic-aliphatic, aromatic, araliphatic, heteroaromatic or heteroaromatic-aliphatic radicals, with R2, if not already covered by the above-mentioned definitions, denoting the side-chain, which is protected if necessary, of a naturally occurring alpha -amino acid, R4 can additionally represent R3 denotes an optionally substituted aliphatic, alicyclic, aromatic or araliphatic radical, or R3 and R4 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, agents containing these, and the use thereof as pharmaceuticals having a psychotropic action for the prophylaxis of disorders of the central nervous system, especially having a nootropic action for the treatment of cognitive dysfunctions.

公开(公告)号：DK435289A

公开(公告)日：1990-03-04

申请号：DK435289

申请日：1989-09-01

Applicant: HOECHST AG

Inventor： NICKEL WOLF-ULRICH ,  HOCK FRANZ ,  WIEMER GABRIELE ,  HENNING RAINER ,  RUEGER WOLFGANG ,  LERCH ULRICH ,  URBACH HANSJOERG

IPC: A61K31/495 ,  A61P25/00 ,  A61P25/28 ,  C07D241/08 ,  C07D403/04 ,  C07D405/04 ,  C07D455/04 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D513/04 ,  C07K1/113 ,  C07K5/06

Abstract: The invention relates to compounds of the formula I (I) in which R1, R2 and R4 represent optionally substituted aliphatic, alicyclic, alicyclic-aliphatic, aromatic, araliphatic, heteroaromatic or heteroaromatic-aliphatic radicals, with R2, if not already covered by the above-mentioned definitions, denoting the side-chain, which is protected if necessary, of a naturally occurring alpha -amino acid, R4 can additionally represent R3 denotes an optionally substituted aliphatic, alicyclic, aromatic or araliphatic radical, or R3 and R4 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, agents containing these, and the use thereof as pharmaceuticals having a psychotropic action for the prophylaxis of disorders of the central nervous system, especially having a nootropic action for the treatment of cognitive dysfunctions.

公开(公告)号：NO932390D0

公开(公告)日：1993-06-30

申请号：NO932390

申请日：1993-06-30

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  WIEMER GABRIELE ,  WAGNER ADELBERT ,  KLEEMANN HEINZ-WERNER

IPC: A61K31/40 ,  A61K31/00 ,  A61K31/41 ,  A61K31/415 ,  A61K31/435 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61K45/00 ,  A61P9/08 ,  A61P9/10 ,  A61P25/28 ,  A61P37/00 ,  C07D207/32 ,  C07D233/84 ,  C07D233/90 ,  C07D255/02 ,  C07D257/04 ,  C07D403/10 ,  C07D471/04 ,  A61K