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公开(公告)号：JPH10130163A
公开(公告)日：1998-05-19
申请号：JP27830197
申请日：1997-10-13
Applicant: HOECHST AG
Inventor： HEITSCH HOLGER DR , HENKE STEPHAN DR , BREIPOHL GERHARD DR , KNOLLE JOCHEN DR , WIRTH KLAUS DR , WIEMER GABRIELE
Abstract: PROBLEM TO BE SOLVED: To obtain an agent useful for the treatment and prevention of Alzheimer's disease by using a bradykinin antagonistic agent (or its physiologically permissible salt) as an active component,. SOLUTION: A bradykinin antagonistic agent (or its physiologically permissible salt) consisting of e.g. a peptide of the formula H-D-Arg-Arg-Pro-Hyp-Gly- Thi-Ser-D-Tic-Oic-Arg-OH (HOE 140) [the abbreviations of the amino acids correspond to conventional 3-letter codes of peptide chemistry described in Europ.J.Biochem.138,9(1984) and the others are Oic: cis, endo-octahydroindole-2- carbonyl; Thi: 2-thienylalanyl; Tic: 1,2,3,4-tetrahydroisoquinolin-3-ylcarbonyl] is used as an agent for the treatment and prevention of Alzheimer's disease. It can be administered by oral, parenteral, nasal, transrectal or respiratory administration in the form suitable for the administration method.
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2.发明专利
公开(公告)号：CA2099447A1
公开(公告)日：1994-01-02
申请号：CA2099447
申请日：1993-06-30
Applicant: HOECHST AG
Inventor： HEITSCH HOLGER , WIEMER GABRIELE , WAGNER ADALBERT , KLEEMANN HEINZ-WERNER
IPC: A61K31/40 , A61K31/00 , A61K31/41 , A61K31/415 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/54 , A61K31/55 , A61K45/00 , A61P9/08 , A61P9/10 , A61P25/28 , A61P37/00 , C07D207/32 , C07D233/84 , C07D233/90 , C07D255/02 , C07D257/04 , C07D403/10 , C07D471/04 , A61K31/395 , A61K31/66
Abstract: Angiotensin II receptor antagonists for the treatment and prophylaxis of coronary heart disease. Antagonists for angiotensin II receptors of the AT1 subtype can be employed for the prophylaxis and combating of coronary heart disease. Furthermore these compounds, such as, for example, azoles of the formula (I) (1) can also be used for the therapy of cognitive and erectile dysfunction.
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公开(公告)号：ZA906327B
公开(公告)日：1991-05-29
申请号：ZA906327
申请日：1990-08-10
Applicant: HOECHST AG
Inventor： LINZ WOLFGANG , WOLFGANG LINZ , URBACH HANSJOERG , HANSJOERG URBACH , HENNING RAINER , RAINER HENNING , SCHOELKENS BERNWARD , BERNWARD SCHOELKENS , SCHOLZ WOLFGANG , WOLFGANG SCHOLZ , TEETZ VOLKER , VOLKER TEETZ , WIEMER GABRIELE , GABRIELE WIEMER
Abstract: The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and hyperplasia by administration of angiotensin converting enzyme inhibitors. Administration of compounds of the formula I (I) in which n is 1 or 2, R, R1, R2 and R3 are identical or different and each is hydrogen or an organic radical, and R4 and R5 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, is preferred. The invention additionally relates to angiotensin converting enzyme inhibitors and to agents containing these for administration for the treatment of the abovementioned diseases.
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公开(公告)号：NO903532A
公开(公告)日：1991-02-12
申请号：NO903532
申请日：1990-08-10
Applicant: HOECHST AG
Inventor： LINZ WOLFGANG , SCHOELKENS BERNWARD , SCHOLZ WOLFGANG , WIEMER GABRIELE , URBACH HANSJOERG , HENNING RAINER , TEETZ VOLKER
CPC classification number: A61K38/556
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公开(公告)号：HU904966D0
公开(公告)日：1991-01-28
申请号：HU496690
申请日：1990-08-10
Applicant: HOECHST AG
Inventor： LINZ WOLFGANG , SCHOLKENS BERNWARD , SCHOLZ WOLFGANG , WIEMER GABRIELE , URBACH HANSJOERG , HENNING RAINER , TEETZ VOLKER
Abstract: The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and hyperplasia by administration of angiotensin converting enzyme inhibitors. Administration of compounds of the formula I (I) in which n is 1 or 2, R, R1, R2 and R3 are identical or different and each is hydrogen or an organic radical, and R4 and R5 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, is preferred. The invention additionally relates to angiotensin converting enzyme inhibitors and to agents containing these for administration for the treatment of the abovementioned diseases.
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Patent Agency Ranking
公开(公告)号：PT91616A
公开(公告)日：1990-03-30
申请号：PT9161689
申请日：1989-09-01
Applicant: HOECHST AG
Inventor： NICKEL WOLF-ULRICH , HENNING RAINER , RUEGER WOLFGANG , LERCH ULRICH , URBACH HANSJOERG , HOCK FRANZ , WIEMER GABRIELE
IPC: A61K31/495 , A61P25/00 , A61P25/28 , C07D241/08 , C07D403/04 , C07D405/04 , C07D455/04 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D513/04 , C07K1/113 , C07K5/06 , C07D241/36
Abstract: The invention relates to compounds of the formula I (I) in which R1, R2 and R4 represent optionally substituted aliphatic, alicyclic, alicyclic-aliphatic, aromatic, araliphatic, heteroaromatic or heteroaromatic-aliphatic radicals, with R2, if not already covered by the above-mentioned definitions, denoting the side-chain, which is protected if necessary, of a naturally occurring alpha -amino acid, R4 can additionally represent R3 denotes an optionally substituted aliphatic, alicyclic, aromatic or araliphatic radical, or R3 and R4 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, agents containing these, and the use thereof as pharmaceuticals having a psychotropic action for the prophylaxis of disorders of the central nervous system, especially having a nootropic action for the treatment of cognitive dysfunctions.
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公开(公告)号：NO893524L
公开(公告)日：1990-03-05
申请号：NO893524
申请日：1989-09-01
Applicant: HOECHST AG
Inventor： NICKEL WOLF-ULRICH , HENNING RAINER , RUEGER WOLFGANG , LERCH ULRICH , URBACH HANSJOERG , HOCK FRANZ , WIEMER GABRIELE
IPC: A61K31/495 , A61P25/00 , A61P25/28 , C07D241/08 , C07D403/04 , C07D405/04 , C07D455/04 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D513/04 , C07K1/113 , C07K5/06
Abstract: The invention relates to compounds of the formula I (I) in which R1, R2 and R4 represent optionally substituted aliphatic, alicyclic, alicyclic-aliphatic, aromatic, araliphatic, heteroaromatic or heteroaromatic-aliphatic radicals, with R2, if not already covered by the above-mentioned definitions, denoting the side-chain, which is protected if necessary, of a naturally occurring alpha -amino acid, R4 can additionally represent R3 denotes an optionally substituted aliphatic, alicyclic, aromatic or araliphatic radical, or R3 and R4 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, agents containing these, and the use thereof as pharmaceuticals having a psychotropic action for the prophylaxis of disorders of the central nervous system, especially having a nootropic action for the treatment of cognitive dysfunctions.
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公开(公告)号：NO893524D0
公开(公告)日：1989-09-01
申请号：NO893524
申请日：1989-09-01
Applicant: HOECHST AG
Inventor： NICKEL WOLF-ULRICH , HENNING RAINER , RUEGER WOLFGANG , LERCH ULRICH , URBACH HANSJOERG , HOCK FRANZ , WIEMER GABRIELE
IPC: A61K31/495 , A61P25/00 , A61P25/28 , C07D241/08 , C07D403/04 , C07D405/04 , C07D455/04 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D513/04 , C07K1/113 , C07K5/06 , C07D
Abstract: The invention relates to compounds of the formula I (I) in which R1, R2 and R4 represent optionally substituted aliphatic, alicyclic, alicyclic-aliphatic, aromatic, araliphatic, heteroaromatic or heteroaromatic-aliphatic radicals, with R2, if not already covered by the above-mentioned definitions, denoting the side-chain, which is protected if necessary, of a naturally occurring alpha -amino acid, R4 can additionally represent R3 denotes an optionally substituted aliphatic, alicyclic, aromatic or araliphatic radical, or R3 and R4 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, agents containing these, and the use thereof as pharmaceuticals having a psychotropic action for the prophylaxis of disorders of the central nervous system, especially having a nootropic action for the treatment of cognitive dysfunctions.
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公开(公告)号：FI894097A0
公开(公告)日：1989-08-31
申请号：FI894097
申请日：1989-08-31
Applicant: HOECHST AG
Inventor： NICKEL WOLF-ULRICH , HENNING RAINER , RUEGER WOLFGANG , LERCH ULRICH , URBACH HANSJOERG , HOCK FRANZ , WIEMER GABRIELE
IPC: A61K31/495 , A61P25/00 , A61P25/28 , C07D241/08 , C07D403/04 , C07D405/04 , C07D455/04 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D513/04 , C07K1/113 , C07K5/06 , C07D
Abstract: The invention relates to compounds of the formula I (I) in which R1, R2 and R4 represent optionally substituted aliphatic, alicyclic, alicyclic-aliphatic, aromatic, araliphatic, heteroaromatic or heteroaromatic-aliphatic radicals, with R2, if not already covered by the above-mentioned definitions, denoting the side-chain, which is protected if necessary, of a naturally occurring alpha -amino acid, R4 can additionally represent R3 denotes an optionally substituted aliphatic, alicyclic, aromatic or araliphatic radical, or R3 and R4 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, agents containing these, and the use thereof as pharmaceuticals having a psychotropic action for the prophylaxis of disorders of the central nervous system, especially having a nootropic action for the treatment of cognitive dysfunctions.
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公开(公告)号：ZA879330B
公开(公告)日：1988-07-27
申请号：ZA879330
申请日：1987-12-11
Applicant: HOECHST AG
Inventor： KUNSTMANN RUDOLF , RUDOLF KUNSTMANN , HOCK FRANZ , FRANZ HOCK , WIEMER GABRIELE , GABRIELE WIEMER
IPC: C07D209/14 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/445 , A61K31/451 , A61K31/495 , A61P25/18 , A61P25/28 , C07C231/00 , C07C231/02 , C07C237/04 , C07C237/20 , C07C237/22 , C07D209/16 , C07D211/14 , C07D211/30 , C07D211/70 , C07D295/14 , C07D295/15 , C07D307/66 , C07D307/82 , C07D333/20 , C07D333/58 , C07D , C07C
Abstract: Aminopropionic acid amides of the formula I in which A, X and Z have the meanings indicated, and their physiologically tolerable salts are used as medicaments in which these compounds in particular have nootropic action.
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