公开(公告)号：CA3025874A1

公开(公告)日：2017-12-07

申请号：CA3025874

申请日：2017-05-09

Applicant: HOFFMANN LA ROCHE

Inventor： DUKE DAVID L ,  RINGEMANN CHRISTIAN ,  MANOHAR CHINMAY UDAY ,  GREENBURG ALAN

IPC: A61M5/172 ,  A61B5/145 ,  G16H20/10 ,  G16H50/20

Abstract: Methods and systems are disclosed for determining a basal rate adjustment of insulin based on risk associated with a glucose state of a person with diabetes. A method may include detecting a glucose state of the person based on a received glucose measurement signal and determining a current risk metric associated with the detected glucose state. The method may include determining a current risk metric associated with the detected glucose state based on a weighted average of cumulative hazard values of return paths generated from a glucose state distribution around a detected glucose state. The method may include calculating an adjustment to a basal rate of a therapy delivery device based on the current risk metric associated with the detected glucose state and a reference risk metric associated with a reference glucose level.

公开(公告)号：HK1218778A1

公开(公告)日：2017-03-10

申请号：HK16106726

申请日：2016-06-13

Applicant: HOFFMANN LA ROCHE

Inventor： HOENES JOACHIM ,  RINGEMANN CHRISTIAN ,  WELLER ANDREAS

IPC: G01N20060101

公开(公告)号：CA2897627A1

公开(公告)日：2014-09-25

申请号：CA2897627

申请日：2014-03-18

Applicant: HOFFMANN LA ROCHE

Inventor： HOENES JOACHIM ,  RINGEMANN CHRISTIAN ,  WELLER ANDREAS

IPC: G01N33/543

Abstract: A method for detecting an analyte in a body fluid is disclosed. The method has the following steps: a) applying a sample (122) of the body fluid to a test element (120), said test element (120) comprising at least (i) a test field (128) comprising at least one test material (130) adapted to change at least one measurable property in the presence of the analyte, (ii) a capillary element (126) adapted to guide the sample (122) across said test field (128) in a flow direction (146), (iii) a first and a second measurement location (158, 160) within said test field (128), wherein the second measurement location (160) is offset from the first measurement location (158) in the flow direction (146); b) measuring the measurable property in said at least one first measurement location (158), thereby generating at least one first measurement value; c) measuring the measurable property in said at least one second measurement location (160), thereby generating at least one second measurement value; d) detecting the analyte by using an evaluation algorithm having at least two input variables, wherein (i) at least one first input variable of the at least two input variables includes an information on a difference between the first measurement value and the second measurement value, and (ii) at least one second input variable of the at least two input variables includes a measurement information on an analyte-induced change of the measurable property of the test material (130) in at least part of the test field (128).

公开(公告)号：AU2021274017A1

公开(公告)日：2022-12-01

申请号：AU2021274017

申请日：2021-05-17

Applicant: HOFFMANN LA ROCHE

Inventor： BECKA LARISSA ,  BÜSSER ALEXANDER ,  HUSCHTO TONY ,  KLOPFENSTEIN YANNICK ,  MESTERHAZY DAVID ,  RINDERKNECHT MIKE ,  RINGEMANN CHRISTIAN

IPC: G16H50/20 ,  G16H50/50

Abstract: A method is disclosed for generating a software-implemented module for determining an analyte value, comprising, in an arrangement of one or more data processors: providing a first set of input data indicative of first values measured for a plurality of input parameters, the input parameters comprising a first and a second input parameter; and providing a second set of input data indicative of second values for the plurality of input parameters, the second values comprising an augmented value for at least one input parameter from the plurality of input parameters, the augmented value being different from the first value measured for the at least one input parameter and determined by augmenting the first value; and the first value for at least one remaining input parameter from the plurality of input parameters. The method further comprises: determining first analyte data indicative of a first plurality of analyte values for an analyte by processing the first set of input data by a physiological model; determining second analyte data indicative of a second plurality of analyte values for the analyte by processing the second set of input data by the physiological model; determining a set of training data from both the first analyte data and the second analyte data; determining a set of test data, the set test data being different from the set training data; providing a software-implemented machine learning model configured to determine an analyte value for the analyte; training the software-implemented machine learning model by the set of training data; and testing the software-implemented machine learning model by the set of test data. Furthermore, a system for generating a software-implemented module for determining an analyte value, a computer program product for generating a software-implemented module for determining an analyte value, a method for determining an analyte value, and a system for determining an analyte value are provided.

公开(公告)号：ES2920809T3

公开(公告)日：2022-08-09

申请号：ES16168149

申请日：2016-05-03

Applicant: HOFFMANN LA ROCHE

Inventor： RINGEMANN CHRISTIAN ,  STEIGER BERND

IPC: G16H50/20 ,  G16H40/63 ,  G16H50/30

Abstract: Se revela un dispositivo de sensor (112) para detectar al menos un analito en un fluido corporal de un usuario. El dispositivo sensor (112) comprende al menos un dispositivo de evaluación (134) configurado para evaluar un flujo de datos de concentraciones dependientes del tiempo C del analito. El dispositivo de evaluación (134) comprende al menos un dispositivo comparador (140) configurado para comparar un valor actual C (t) de la concentración C con al menos un valor umbral del primer umbral L y con al menos un valor umbral H, con H % 26gt; L. El dispositivo de evaluación (134) está configurado para definir un intervalo de tiempo de tolerancia (158). Además, el dispositivo de evaluación (134), mediante el uso del dispositivo comparador (140), se configura para detectar si la concentración C aumenta y excede el primer valor umbral L durante el intervalo de tiempo de tolerancia (158) y para preparar una señal de advertencia en consecuencia. El dispositivo de evaluación (134) está configurado para suprimir una salida de la señal de advertencia W al menos hasta que expire el intervalo de tiempo de tolerancia (158), bajo la condición previa que c (t)

公开(公告)号：CA2884919C

公开(公告)日：2021-05-04

申请号：CA2884919

申请日：2013-12-19

Applicant: HOFFMANN LA ROCHE

Inventor： RINGEMANN CHRISTIAN ,  PLUM MARKUS ,  PETRICH WOLFGANG ,  OTTENSTEIN TIMO

IPC: G01N33/557 ,  C12Q1/54 ,  G01N21/27 ,  G01N21/88 ,  G01N33/66

Abstract: A method for analyzing at least one sample of a body fluid, for example determining blood glucose concentration, is proposed. The method comprises the following steps: a) recording a plurality of measurement values by monitoring a time development of at least one measurement value indicating a progress of a detection reaction of at least one test substance (126) and the sample of a the body fluid, and providing at least one measurement curve F(t) which contains the measurement values, wherein at least an evaluation part of the measurement curve has an exponential characteristic, wherein the measurement values contained in the measurement curve are acquired at differing points in time, wherein the detection reaction is known to be influenced by a concentration c of an analyte to be detected in the body fluid and at least one disturbance variable Y; b) deriving an end value of the measurement curve, wherein the end value forms a first variable x1; c) deriving at least one fit parameter from the measurement curve by taking into account the exponential characteristic of at least the evaluation part of the measurement curve, wherein the fit parameter forms at least one second variable x2; d) deriving the concentration c of the analyte by using at least one multivariate evaluation algorithm, the multivariate evaluation algorithm being adapted to combine the first variable x and the second variable x2.

公开(公告)号：DK3220137T3

公开(公告)日：2019-05-06

申请号：DK16160136

申请日：2016-03-14

Applicant: HOFFMANN LA ROCHE

Inventor： WIEDER HERBERT ,  RINGEMANN CHRISTIAN

IPC: G01N27/327 ,  C12Q1/00

公开(公告)号：AU2017275393A1

公开(公告)日：2019-01-03

申请号：AU2017275393

申请日：2017-05-09

Applicant: HOFFMANN LA ROCHE

Inventor： DUKE DAVID L ,  RINGEMANN CHRISTIAN ,  MANOHAR CHINMAY UDAY

Abstract: Methods and systems are disclosed for determining a basal rate adjustment of insulin in a continuous glucose monitoring system of a person with diabetes. A method may include receiving, by at least one computing device, a signal representative of at least one glucose measurement and detecting, by the at least one computing device, a glucose state of the person based on the signal, the detected glucose state including a glucose level of the person and a rate of change of the glucose level. The method may also include calculating, by the at least one computing device, an adjustment to a basal rate of a therapy delivery device based on a control-to-range algorithm and at least one failsafe constraint to account for changes in the insulin sensitivity of the person with diabetes or inaccurate glucose measurement.

公开(公告)号：CA3025902A1

公开(公告)日：2017-12-07

申请号：CA3025902

申请日：2017-05-09

Applicant: HOFFMANN LA ROCHE

Inventor： DUKE DAVID L ,  RINGEMANN CHRISTIAN ,  MANOHAR CHINMAY UDAY

IPC: A61B5/145 ,  A61M5/172 ,  G16H20/17 ,  G16H40/67 ,  G16H50/20

Abstract: Methods and systems are disclosed for determining a basal rate adjustment of insulin in a continuous glucose monitoring system of a person with diabetes. A method may include receiving, by at least one computing device, a signal representative of at least one glucose measurement and detecting, by the at least one computing device, a glucose state of the person based on the signal, the detected glucose state including a glucose level of the person and a rate of change of the glucose level. The method may also include calculating, by the at least one computing device, an adjustment to a basal rate of a therapy delivery device based on a control-to-range algorithm and at least one failsafe constraint to account for changes in the insulin sensitivity of the person with diabetes or inaccurate glucose measurement.

公开(公告)号：CA3022118A1

公开(公告)日：2017-11-09

申请号：CA3022118

申请日：2017-05-03

Applicant: HOFFMANN LA ROCHE

Inventor： RINGEMANN CHRISTIAN ,  STEIGER BERND

Abstract: A sensor device (112) for detecting at least one analyte in a body fluid of a user is disclosed. The sensor device (112) comprisesat least one evaluation device (134) configured for evaluating a data stream of time-dependent concentrations c of the analyte.The evaluation device (134) comprises at least one comparator device (140) configured for comparing a current value c(t) of the concentration cwith at least one first threshold value L and with at least one second threshold value H, with H > L. The evaluation device (134)is configured to define a tolerance time interval(158). Further, the evaluation device (134), by using the comparator device (140), is configuredto detect if the concentrationcrises and exceeds the first threshold value L during the tolerance time interval (158)and to prepare a warning signal W accordingly. Theevaluation device (134)is configured to suppressan output of the warning signal W at least until the tolerance time interval (158) expires, under the precondition that c(t)