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    METHOD FOR EVALUATING MEDICAL MEASUREMENT CURVES
    3.
    发明专利
    METHOD FOR EVALUATING MEDICAL MEASUREMENT CURVES 未知

    公开(公告)号：CA2896152A1

    公开(公告)日：2014-06-26

    申请号：CA2896152

    申请日：2013-12-19

    Applicant: HOFFMANN LA ROCHE

    Inventor： AIGNER SIMON ,  CHEMNITIUS GABRIELE ,  HORN CARINA ,  LIMBURG BERND ,  OTTENSTEIN TIMO ,  PETRICH WOLFGANG ,  PLUM MARKUS ,  RINGEMANN CHRISTIAN ,  SERR MARKUS

    IPC: G01N21/77 ,  G01N21/27 ,  G01N21/84

    Abstract: A method for detecting an analyte in a sample of a body fluid comprising the steps of: a) providing an optical measurement curve, which contains a plurality of measurement values recorded by monitoring a time development of a measurement value indicating a progress of a detection reaction of a test substance and the sample of a body fluid, wherein the detection reaction is known to be influenced by a set of state variables; b) providing a set of at least two different evaluation rules being adapted to derive a characteristic value from the optical measurement curve, thereby deriving a set of characteristic values X={Xi} i=1...N from the optical measurement curve; c) performing a multivariate analysis of the first and the second characteristic value by using a predetermined multivariate evaluation algorithm adapted to derive a result from at least two variables, wherein the at least one first and second characteristic value are used as the at least two variables, thereby deriving an estimate value for at least one target variable Y of the state variables; d) determining a concentration of the analyte by using the variable Y.

    METHOD FOR EVALUATING MEDICAL MEASUREMENT CURVES
    4.
    发明专利
    METHOD FOR EVALUATING MEDICAL MEASUREMENT CURVES 未知

    公开(公告)号：CA2896152C

    公开(公告)日：2018-07-24

    申请号：CA2896152

    申请日：2013-12-19

    Applicant: HOFFMANN LA ROCHE

    Inventor： AIGNER SIMON ,  CHEMNITIUS GABRIELE ,  HORN CARINA ,  LIMBURG BERND ,  OTTENSTEIN TIMO ,  PETRICH WOLFGANG ,  PLUM MARKUS ,  RINGEMANN CHRISTIAN ,  SERR MARKUS

    IPC: G01N21/77 ,  G01N21/27 ,  G01N21/84

    Abstract: A method for detecting an analyte in a sample of a body fluid comprising the steps of: a) providing an optical measurement curve, which contains a plurality of measurement values recorded by monitoring a time development of a measurement value indicating a progress of a detection reaction of a test substance and the sample of a body fluid, wherein the detection reaction is known to be influenced by a set of state variables; b) providing a set of at least two different evaluation rules being adapted to derive a characteristic value from the optical measurement curve, thereby deriving a set of characteristic values X={Xi} i=1...N from the optical measurement curve; c) performing a multivariate analysis of the first and the second characteristic value by using a predetermined multivariate evaluation algorithm adapted to derive a result from at least two variables, wherein the at least one first and second characteristic value are used as the at least two variables, thereby deriving an estimate value for at least one target variable Y of the state variables; d) determining a concentration of the analyte by using the variable Y.

    METHOD FOR ANALYZING A SAMPLE OF A BODY FLUID
    6.
    发明专利
    METHOD FOR ANALYZING A SAMPLE OF A BODY FLUID 未知

    公开(公告)号：CA2884919C

    公开(公告)日：2021-05-04

    申请号：CA2884919

    申请日：2013-12-19

    Applicant: HOFFMANN LA ROCHE

    Inventor： RINGEMANN CHRISTIAN ,  PLUM MARKUS ,  PETRICH WOLFGANG ,  OTTENSTEIN TIMO

    IPC: G01N33/557 ,  C12Q1/54 ,  G01N21/27 ,  G01N21/88 ,  G01N33/66

    Abstract: A method for analyzing at least one sample of a body fluid, for example determining blood glucose concentration, is proposed. The method comprises the following steps: a) recording a plurality of measurement values by monitoring a time development of at least one measurement value indicating a progress of a detection reaction of at least one test substance (126) and the sample of a the body fluid, and providing at least one measurement curve F(t) which contains the measurement values, wherein at least an evaluation part of the measurement curve has an exponential characteristic, wherein the measurement values contained in the measurement curve are acquired at differing points in time, wherein the detection reaction is known to be influenced by a concentration c of an analyte to be detected in the body fluid and at least one disturbance variable Y; b) deriving an end value of the measurement curve, wherein the end value forms a first variable x1; c) deriving at least one fit parameter from the measurement curve by taking into account the exponential characteristic of at least the evaluation part of the measurement curve, wherein the fit parameter forms at least one second variable x2; d) deriving the concentration c of the analyte by using at least one multivariate evaluation algorithm, the multivariate evaluation algorithm being adapted to combine the first variable x and the second variable x2.

    METHOD FOR ANALYZING A SAMPLE OF A BODY FLUID
    8.
    发明专利
    METHOD FOR ANALYZING A SAMPLE OF A BODY FLUID 未知

    公开(公告)号：CA2884919A1

    公开(公告)日：2014-06-26

    申请号：CA2884919

    申请日：2013-12-19

    Applicant: HOFFMANN LA ROCHE

    Inventor： RINGEMANN CHRISTIAN ,  PLUM MARKUS ,  PETRICH WOLFGANG ,  OTTENSTEIN TIMO

    IPC: G01N33/557 ,  C12Q1/54 ,  G01N21/27 ,  G01N21/88 ,  G01N33/66 ,  G06F19/00

    Abstract: A method for analyzing at least one sample of a body fluid, for example determining blood glucose concentration, is proposed. The method comprises the following steps: a) recording a plurality of measurement values by monitoring a time development of at least one measurement value indicating a progress of a detection reaction of at least one test substance (126) and the sample of a the body fluid, and providing at least one measurement curve F(t) which contains the measurement values, wherein at least an evaluation part of the measurement curve has an exponential characteristic, wherein the measurement values contained in the measurement curve are acquired at differing points in time, wherein the detection reaction is known to be influenced by a concentration c of an analyte to be detected in the body fluid and at least one disturbance variable Y; b) deriving an end value of the measurement curve, wherein the end value forms a first variable x1; c) deriving at least one fit parameter from the measurement curve by taking into account the exponential characteristic of at least the evaluation part of the measurement curve, wherein the fit parameter forms at least one second variable x2; d) deriving the concentration c of the analyte by using at least one multivariate evaluation algorithm, the multivariate evaluation algorithm being adapted to combine the first variable x and the second variable x2.

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