公开(公告)号：DE69432219D1

公开(公告)日：2003-04-10

申请号：DE69432219

申请日：1994-05-20

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01J13/02

Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.

公开(公告)号：AT227960T

公开(公告)日：2002-12-15

申请号：AT94919184

申请日：1994-05-19

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K48/00 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01J13/02

Abstract: Methods of and apparatus for preparing gas-filled liposomes are described. Gas-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.

公开(公告)号：AU9383098A

公开(公告)日：1999-04-05

申请号：AU9383098

申请日：1998-09-09

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  GERTZ EDWARD W

IPC: A61K49/22 ,  A61K49/04 ,  A61K9/127 ,  A61K9/50

公开(公告)号：CA2164846A1

公开(公告)日：1994-12-22

申请号：CA2164846

申请日：1994-05-19

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： RAMASWAMI VARADARAJAN ,  UNGER EVAN C ,  WU GUANLI ,  YELLOWHAIR DAVID ,  MATSUNAGA TERRY ,  FRITZ THOMAS A

IPC: A61K8/14 ,  A61K9/127 ,  A61K9/14 ,  A61K41/00 ,  A61K47/48 ,  A61K49/04 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B28B1/54 ,  A61K9/16 ,  A61K31/70 ,  A61K38/17 ,  A61K38/19 ,  A61K39/00 ,  A61K39/395 ,  A61K48/00 ,  A61N2/00 ,  A61N5/00 ,  A61N7/00 ,  B01J13/02

Abstract: Therapeutic delivery systems comprising gaseous precursor-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Therapeutic delivery systems comprising gaseous precursor-filled liposomes having encapsulated therein a contrast agent or drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in therapeutic delivery applications are also disclosed.

公开(公告)号：CA2164844A1

公开(公告)日：1994-12-22

申请号：CA2164844

申请日：1994-05-19

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： YELLOWHAIR DAVID ,  WU GUANLI ,  UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K48/00 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01J13/02 ,  A61K47/24

Abstract: Methods of and apparatus for preparing gas-filled liposomes are do- scribed. Gas-filled liposomes prepared by these methods are particularly use- ful, for example, in ultrasonic imaging applications and is therapeutic drug delivery systems.

公开(公告)号：EP0930844A4

公开(公告)日：2002-03-13

申请号：EP97928998

申请日：1997-06-16

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY O ,  FRITZ THOMAS A ,  RAMASWAMI VARADA RAJAN

IPC: A61M5/00 ,  A61B8/00 ,  A61K49/00 ,  A61K49/22 ,  A61K51/02 ,  A61B5/055

CPC classification number: A61K49/223 ,  Y10S977/801 ,  Y10S977/927 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93

Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

公开(公告)号：EP0707471A4

公开(公告)日：1998-07-29

申请号：EP94920019

申请日：1994-05-19

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K31/70 ,  A61K39/395 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00

CPC classification number: A61K49/22 ,  A61K9/127 ,  A61K9/1277 ,  A61K9/1278 ,  A61K41/0028 ,  A61K41/0052 ,  A61K47/6925 ,  A61K49/1815 ,  A61K49/223 ,  A61K49/227 ,  A61M5/3145 ,  Y10S436/829 ,  Y10S977/801 ,  Y10S977/907 ,  Y10S977/915

公开(公告)号：DE69738964D1

公开(公告)日：2008-10-16

申请号：DE69738964

申请日：1997-06-16

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY O ,  FRITZ THOMAS A ,  RAMASWAMI VARADA RAJAN

IPC: A61B5/055 ,  A61M5/00 ,  A61B8/00 ,  A61K49/00 ,  A61K49/22 ,  A61K51/02

Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

公开(公告)号：DE69432219T2

公开(公告)日：2003-12-04

申请号：DE69432219

申请日：1994-05-20

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01J13/02

Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.

公开(公告)号：PT712293E

公开(公告)日：2003-07-31

申请号：PT94919208

申请日：1994-05-20

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01J13/02

Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.