公开(公告)号：EP1039834A4

公开(公告)日：2001-12-05

申请号：EP98964127

申请日：1998-12-17

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  WU YUNQIU

IPC: A61K49/00 ,  A61B8/13 ,  A61K41/00

CPC classification number: A61K49/0002

Abstract: The present invention generally relates to optoacoustic contrast agents and methods of diagnostic and therapeutic imaging using optoacoustic contrast agents.

公开(公告)号：EP0707471A4

公开(公告)日：1998-07-29

申请号：EP94920019

申请日：1994-05-19

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K31/70 ,  A61K39/395 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00

CPC classification number: A61K49/22 ,  A61K9/127 ,  A61K9/1277 ,  A61K9/1278 ,  A61K41/0028 ,  A61K41/0052 ,  A61K47/6925 ,  A61K49/1815 ,  A61K49/223 ,  A61K49/227 ,  A61M5/3145 ,  Y10S436/829 ,  Y10S977/801 ,  Y10S977/907 ,  Y10S977/915

公开(公告)号：EP0740528A4

公开(公告)日：1998-04-01

申请号：EP95908414

申请日：1994-11-30

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY ,  YELLOWHAIR DAVID

IPC: A61K8/00 ,  A61K8/11 ,  A61K8/14 ,  A61K8/21 ,  A61K8/25 ,  A61K8/31 ,  A61K8/33 ,  A61K8/34 ,  A61K8/36 ,  A61K8/368 ,  A61K8/37 ,  A61K8/39 ,  A61K8/40 ,  A61K8/41 ,  A61K8/42 ,  A61K8/44 ,  A61K8/46 ,  A61K8/49 ,  A61K8/60 ,  A61K8/64 ,  A61K8/65 ,  A61K8/66 ,  A61K8/70 ,  A61K8/73 ,  A61K8/86 ,  A61K8/92 ,  A61K8/97 ,  A61K9/127 ,  A61K9/50 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q1/00 ,  A61Q1/10 ,  A61Q19/00 ,  A61B8/00

CPC classification number: A61K9/1271 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K9/1277 ,  A61K9/1278 ,  A61K41/0028 ,  A61K41/0052 ,  A61K47/6925 ,  A61K49/1815 ,  A61K49/22 ,  A61K49/223 ,  A61K49/227 ,  A61K2800/87 ,  A61M5/3145 ,  A61Q19/00 ,  Y10S436/829

公开(公告)号：EP0923383A4

公开(公告)日：2001-06-13

申请号：EP97920281

申请日：1997-04-02

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61B8/08 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/30 ,  A61K47/48 ,  A61K49/00 ,  A61K49/04 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01J13/02 ,  G01R33/28

CPC classification number: A61K9/1277 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1278 ,  A61K41/0028 ,  A61K41/0052 ,  A61K49/22 ,  A61K49/223 ,  A61K49/227 ,  A61M5/3145 ,  G01R33/5601

公开(公告)号：EP0831927A4

公开(公告)日：2001-06-06

申请号：EP96916685

申请日：1996-05-28

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K47/24 ,  A61K9/127 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61B8/13 ,  C07D265/30

CPC classification number: A61K49/1806 ,  A61K49/223 ,  A61K49/227 ,  Y10S514/962 ,  Y10S514/963

公开(公告)号：EP0840570A4

公开(公告)日：2001-05-30

申请号：EP96938613

申请日：1996-06-06

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCCREERY THOMAS ,  YELLOWHAIR DAVID ,  BARRETTE TERRENCE R

IPC: A61K49/00 ,  A61B5/055 ,  A61B8/00 ,  A61J3/00 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01F3/04 ,  B01F11/00 ,  B01F15/00

CPC classification number: A61K49/22 ,  A61J3/00 ,  A61K9/127 ,  A61K9/1277 ,  A61K9/1278 ,  A61K41/0028 ,  A61K41/0052 ,  A61K49/1815 ,  A61K49/223 ,  A61K49/227 ,  A61K2800/87 ,  A61M5/3145 ,  B01F3/04099 ,  B01F11/0025 ,  B01F13/0033 ,  B01F15/00435 ,  Y10S366/605

Abstract: A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 eight pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3 DEG . The total length of travel around the figure-8 pattern is at least 0.7 cm.

公开(公告)号：EP0760684A4

公开(公告)日：2000-03-15

申请号：EP95920616

申请日：1995-05-22

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K49/04 ,  A61K49/18

CPC classification number: A61K49/0419 ,  A61K49/1806

Abstract: Novel gas filled microspheres useful as computed tomography (CT) contrast agents. The microspheres are prepared from a gas and/or a gaseous precursor, and one or more stabilizing compounds.

公开(公告)号：EP0836420A4

公开(公告)日：1999-12-08

申请号：EP96920466

申请日：1996-05-24

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  YELLOWHAIR DAVID W

IPC: A61B18/00 ,  A61B8/00 ,  A61B8/08 ,  A61B8/12 ,  A61K41/00 ,  A61K49/22 ,  A61N7/00 ,  G01S15/89 ,  G06T1/00

CPC classification number: A61B8/12 ,  A61B8/0833 ,  A61B8/0883 ,  A61B8/445 ,  A61B8/4483 ,  A61B8/481 ,  A61K41/0028 ,  A61K49/223 ,  A61N7/00 ,  G01S15/8925 ,  G01S15/899

公开(公告)号：EP1001816A4

公开(公告)日：2002-07-17

申请号：EP97946447

申请日：1997-11-03

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K49/22 ,  A61K49/04 ,  A61K47/48 ,  C07C19/08 ,  C07C41/00

CPC classification number: A61K49/223

公开(公告)号：EP1037673A4

公开(公告)日：2002-05-02

申请号：EP98906695

申请日：1998-02-25

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K9/127 ,  A61K41/00 ,  A61K49/22 ,  A61K49/04 ,  A61K9/50 ,  A61K47/48

CPC classification number: A61K49/223 ,  A61K9/1271 ,  A61K41/0028 ,  A61K47/544 ,  Y10T428/2984