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    Blood vessel-strengthening agent
    14.
    发明专利
    Blood vessel-strengthening agent 审中-公开
    血管增强剂

    公开(公告)号：JP2006036673A

    公开(公告)日：2006-02-09

    申请号：JP2004217647

    申请日：2004-07-26

    Applicant: Kao Corp ,  花王株式会社

    Inventor： SOGA HAJIME ,  YOSHIZUKA NAONOBU ,  FUKUDA YUKO ,  MORI SHINOBU

    IPC: A61K36/00 ,  A61K36/02 ,  A61K36/18 ,  A61K36/28 ,  A61K36/42 ,  A61K36/53 ,  A61K36/75 ,  A61K36/896 ,  A61K36/899 ,  A61P7/04 ,  A61P9/00 ,  A61P9/14 ,  A61P17/00 ,  A61P17/16 ,  A61P43/00

    Abstract: PROBLEM TO BE SOLVED: To provide a blood vessel-strengthening agent having excellent blood vessel-strengthening action and useful as a medicine or a cosmetic. SOLUTION: The blood vessel-strengthening agent comprises a plant selected from rosemary, sage, Geranium thunbergii Siebold et Zuccarini (Geraniaceae), Coix lacryma-jobi L. var., Equisetum arvense L, Citrus aurantium Linne or Citrus aurantium Linne var. daidai Makino, Fucus Vesiculosis, Arctium lappa Linne (Compositae), Houttuynia cordata Thunberg (Saururaceae), Zanthoxylum piperitum De Candolla or a plant of the same genus, Ophiopogon japonica or a plant of the same genus, Ginkgo biloba Linne (Ginkgoaceae), Zizyphus jujuba MILL. var. inermis (BUNGE) REHD. and Luffa cylindrica M. Reomen (Cucurbitaceae) or Luffa cylindrica (Cucurbitaceae), or its extract as an active ingredient. COPYRIGHT: (C)2006,JPO&NCIPI

    Abstract translation: 要解决的问题：提供具有优异的血管强化作用的血管强化剂，并且可用作药物或化妆品。 解决方案：血管强化剂包括选自迷迭香，鼠尾草，天竺葵（Siebold）和茜草（Geraniaceae），ix藜（Coix lacryma-jobi L. var。），白，，（Equisetum arvense L），枸杞（Citrus aurantium Linne） 。 d ai Mak，，hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus hus 朱朱山 变种。 真皮（BUNGE）REHD。 和Luffa cylindrica M. Reomen（葫芦科）或Luffa cylindrica（葫芦科），或其提取物作为活性成分。 版权所有（C）2006，JPO＆NCIPI

    Method for screening capillary stabilizer
    15.
    发明专利
    Method for screening capillary stabilizer 审中-公开
    筛选毛细管稳定剂的方法

    公开(公告)号：JP2006034157A

    公开(公告)日：2006-02-09

    申请号：JP2004217648

    申请日：2004-07-26

    Applicant: Kao Corp ,  花王株式会社

    Inventor： SOGA HAJIME ,  MORI SHINOBU ,  FUKUDA YUKO ,  YOSHIZUKA NAONOBU

    IPC: C12Q1/02 ,  G01N33/15

    Abstract: PROBLEM TO BE SOLVED: To provide a method for readily and precisely screening a capillary stabilizer or the like in vitro.
    SOLUTION: The method for screening a shrinkage inhibitor of a vascular endothelial cell or the capillary stabilizer comprises culturing a collagen gel seeded with the vascular endothelial cell, with a tested sample for a prescribed time, and measuring a gel area of the collagen gel to judge the gel shrinkage-inhibiting effects of the test sample.
    COPYRIGHT: (C)2006,JPO&NCIPI

    Abstract translation: 要解决的问题：提供一种容易且精确地筛选毛细管稳定剂等的体外方法。 解决方案：用于筛选血管内皮细胞或毛细管稳定剂的收缩抑制剂的方法包括用测试的样品培养接种血管内皮细胞的胶原凝胶一段规定的时间，并测量胶原蛋白的凝胶面积 凝胶来测定试样的凝胶收缩抑制效果。 版权所有（C）2006，JPO＆NCIPI

    PRODUCTION OF GLUCOSYL CERAMIDE SYNTHASE
    18.
    发明专利
    PRODUCTION OF GLUCOSYL CERAMIDE SYNTHASE 失效

    公开(公告)号：JP2000232881A

    公开(公告)日：2000-08-29

    申请号：JP3577699

    申请日：1999-02-15

    Applicant: KAO CORP ,  RIKAGAKU KENKYUSHO

    Inventor： WAKIZAKA ETSUJI ,  MATSUO NOBORU ,  TAKIZAWA MINORU ,  NOMURA TOMOKO ,  YOSHIZUKA NAONOBU ,  HIRABAYASHI YOSHIO ,  ICHIKAWA SHINICHI

    IPC: C12N15/09 ,  C12N5/10 ,  C12N9/24

    Abstract: PROBLEM TO BE SOLVED: To obtain a new recombinant bacmid which is obtained by inserting a specific transfer vector, in which a gene coding for glucosyl ceramide synthase is inserted, into a bacmid DNA and is used in the production or the like of an enzyme useful in the synthesis or the like of sphingoglycolipid. SOLUTION: This is a new recombinant bacmid for expressing glucosyl ceramide synthase obtained by inserting transfer vector pFastBacHT, in which a gene coding for glucosyl ceramide synthase is inserted, into a bacmid DNA and is used for efficiently producing glucosyl ceramide synthase useful in the synthesis or the like of sphingoglycolipid. The recombinant bacmid for expressing this enzyme is obtained by inserting the gene coding for glucosyl ceramide synthase originating from tissues in mammalia, e.g. human being, rat, mouse, cattle, pig and the like, into transfer vector pFastBacHT on the market and further inserting this into the bacmid DNA.

    NEW PROTEIN SHOWING CHEMOTAXIS-ENHANCING EFFECT
    19.
    发明专利
    NEW PROTEIN SHOWING CHEMOTAXIS-ENHANCING EFFECT 失效

    公开(公告)号：JPH05117299A

    公开(公告)日：1993-05-14

    申请号：JP30133291

    申请日：1991-10-22

    Applicant: KAO CORP

    Inventor： YOSHIZUKA NAONOBU ,  YOSHIMURA MASAAKI ,  OUCHI ATSUSHI

    IPC: A61K38/00 ,  A61P43/00 ,  C07K14/435 ,  C12P21/00 ,  C12R1/91

    Abstract: PURPOSE:To obtain the subject new protein showing an activity enhancing the chemotactic effect of macrophage chemotactic factor and useful, e.g. as a reagent for immunological study of macrophage or an auxiliary anti-neoplastic agent by culturing lymphoid cells. CONSTITUTION:Lymphoid cells, e.g. hybridoma D6-1 cells obtained by cell fusion between human peripheral lymphocyte and human acute T-cell leukemia cell strain in 45% polyethylene glycol are dispersed in a culture medium and incubated at 37 deg.C for 90min. The cultured solution is subsequently centrifuged and the resultant supernatant is collected. The collected supernatant is purified by the anion-exchange column chromatography in which DEAE-agarose, etc., bufferized by 5mM N-2-hydroxyethylpiperazin-N'-2-ethanesulfonic acid buffer solution (Hz 8.0) is used, thus obtaining the objective new protein capable of enhancing the macrophage chemotactic effect to the macrophage chemotactic factor, produced in lymphocyte and/or lymphoid cells and having about 13000 molecular weight measured by gel filtration method.

    HAIR GROWTH AGENT
    20.
    发明专利
    HAIR GROWTH AGENT 失效

    公开(公告)号：JPH0565213A

    公开(公告)日：1993-03-19

    申请号：JP22921091

    申请日：1991-09-09

    Applicant: KAO CORP

    Inventor： KIDENA HIDEFUMI ,  HIRAYAMA NORIKO ,  HOTTA MITSUYUKI ,  MEGURO SHINICHI ,  YOSHIZUKA NAONOBU ,  NISHIZAWA YOSHINORI

    IPC: A61K8/00 ,  A61K8/97 ,  A61Q5/00 ,  A61Q7/00

    Abstract: PURPOSE:To obtain a hair growth agent, capable of promoting hair growth regardless of symptoms or physical constitution and effective against various alopecias. CONSTITUTION:A hair growth agent is obtained by blending carrageenan moss or its extract, especially an extract prepared by, grinding the whole alga of the carrageenan moss or part thereof and extracting with water, a lower alcohol, hydrocarbons or esters, then treating the extracted phase with active carbon, etc., eluting an adsorbed active ingredient with methanol, etc., and distilling away the solvent as the active ingredient at a concentration of preferably 0.0001-50wt.%, especially 0.001-10wt.% expressed in terms of a dry substance (0.01-10wt.% when the dosage form is a liquid such as a suspension or a paste such as an ointment) in using the extract and preferably 0.001-50wt.%, especially 0.01-20wt.% in using the carrageenan moss itself with other ingredients. The resultant hair growth agent has the above-mentioned effects. Furthermore, the dosage form is not especially limited if the hair growth agent is used as a medicine for external use. The dosage form is preferably a liniment such as an ointment, a lotion, a tonic, a spray, a suspension or an emulsion.

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