公开(公告)号：EP2658527A4

公开(公告)日：2014-10-15

申请号：EP11852627

申请日：2011-12-29

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR CHARLES DOUGLAS ,  ZANI BRETT G ,  KIORPES TIMOTHY CHARLES

IPC: A61L29/16

CPC classification number: B82Y5/00 ,  A61K31/436 ,  A61L29/085 ,  A61L29/143 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/624 ,  A61L2300/802 ,  A61L2400/12

Abstract: Devices, coatings, and methods therefore comprise a medical device for delivering nanoparticles of an active agent to a treatment site. A coating on the medical device comprises active agent nanoparticles, which delivers coating to the treatment site and releases active agent nanoparticles into the treatment site over at least one day. A coating may comprise a polymer, a surfactant, and the nanoparticles. The coating may be prepared by forming a nanoemulsion. A coating may comprise encapsulated active agent nanoparticles which comprise active agent nanoparticles encapsulated in a polymer. The coating may have a positive surface charge. The coating may deliver active agent nanoparticles into the treatment site over at least about one day. The coating may be formed of a surfactant and nanoparticles mixture. The active agent nanoparticles may be deposited on the medical device using electrostatic capture.

Abstract translation: 因此，装置，涂层和方法包括用于将活性剂的纳米颗粒递送到治疗部位的医疗装置。 医疗装置上的涂层包括活性剂纳米颗粒，其将涂层递送至处理部位，并在至少一天内将活性剂纳米颗粒释放到治疗部位。 涂层可以包括聚合物，表面活性剂和纳米颗粒。 可以通过形成纳米乳液来制备涂层。 涂层可以包含包封在聚合物中的活性剂纳米颗粒的包封的活性剂纳米颗粒。 涂层可能具有正表面电荷。 涂层可在至少约一天内将活性剂纳米颗粒递送至处理部位。 涂层可以由表面活性剂和纳米颗粒混合物形成。 可以使用静电捕获将活性剂纳米颗粒沉积在医疗装置上。

公开(公告)号：EP2593039A4

公开(公告)日：2014-10-15

申请号：EP11807601

申请日：2011-07-15

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR DOUGLAS ,  ZANI BRETT G ,  NEET JOHN ,  KIORPES TIMOTHY CHARLES

IPC: A61L29/16

CPC classification number: A61M25/10 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61M25/1011

Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.