公开(公告)号：CA2810842C

公开(公告)日：2018-06-26

申请号：CA2810842

申请日：2011-09-09

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  CARLYLE WENDA C ,  TAYLOR CHARLES DOUGLAS

IPC: A61K47/34 ,  A61K9/00 ,  A61K9/70 ,  A61K47/30 ,  A61M37/00

Abstract: Provided is a drug delivery composition comprising at least one polymer and at least one active agent; wherein the active agent is present in crystalline form on at least one region of an outer surface of the composition and wherein active agent surface content is adjusted to provide a selected active agent release profile.

公开(公告)号：AU2011256902B2

公开(公告)日：2015-03-12

申请号：AU2011256902

申请日：2011-12-16

Applicant: MICELL TECHNOLOGIES INC

Inventor： TAYLOR CHARLES DOUGLAS ,  MCCLAIN JAMES B ,  SMOKE CLINT ,  COLE MICHAEL E ,  DEYOUNG JAMES

IPC: B05D3/00 ,  A61L2/00

Abstract: C:\Documnsand Scuin\pSXD\LalSettins\Tcmp\DcsCorp\OCR\3AGEo IOCRdo-L2/620II A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate; wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent. 4-j 4-04 = ) I -j co0 xo: uit

公开(公告)号：CA2905419A1

公开(公告)日：2014-10-09

申请号：CA2905419

申请日：2014-03-12

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR CHARLES DOUGLAS ,  BURGERMEISTER ROBERT STEVEN

IPC: A61F2/00

Abstract: A bioabsorbable biomedical implant is disclosed. The implant includes a tubular scaffold comprising a plurality of interconnected polymer struts. The interconnected polymer struts defines a plurality of deformable cells. The polymer struts have an average strut thickness of no more than about 120 µ??. Methods for making the bioabsorbable biomedical implant, including the methods for making the polymer materials for the tubular scaffold, are also disclosed.

公开(公告)号：CA2852260A1

公开(公告)日：2013-04-25

申请号：CA2852260

申请日：2012-10-18

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR CHARLES DOUGLAS

IPC: A61M31/00

Abstract: A medical device that releases a pharmaceutical agent to a target site is disclosed. The medical device includes a balloon, and a coating on at least a portion of the balloon. Each particle of the particles of the pharmaceutical agent is at least partially encapsulated in a polymer layer. The method includes the steps of providing a device including a balloon, and a coating on at least a portion of the balloon, the coating including particles of a pharmaceutical agent, and each particle of the pharmaceutical agent is at least partially encapsulated in a polymer layer; positioning the device to allow the balloon to reach the target site; and inflating the balloon of the device.

公开(公告)号：AU2017210510B2

公开(公告)日：2019-09-19

申请号：AU2017210510

申请日：2017-08-01

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR CHARLES DOUGLAS ,  FAGAN MEAGAN M

IPC: A61M31/00

Abstract: Abstract A medical device that releases a pharmaceutical agent to a target site is disclosed. The medical device includes a balloon, and a coating on at least a portion of the balloon. Each particle of the particles of the pharmaceutical agent is at least partially encapsulated in a polymer layer. The method includes the steps of providing a device including a balloon, and a coating on at least a portion of the balloon, the coating including particles of a pharmaceutical agent, and each particle of the pharmaceutical agent is at least partially encapsulated in a polymer layer; positioning the device to allow the balloon to reach the target site; and inflating the balloon of the device.

公开(公告)号：AU2017210510A1

公开(公告)日：2017-08-17

申请号：AU2017210510

申请日：2017-08-01

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR CHARLES DOUGLAS ,  FAGAN MEAGAN M

IPC: A61M31/00

Abstract: Abstract A medical device that releases a pharmaceutical agent to a target site is disclosed. The medical device includes a balloon, and a coating on at least a portion of the balloon. Each particle of the particles of the pharmaceutical agent is at least partially encapsulated in a polymer layer. The method includes the steps of providing a device including a balloon, and a coating on at least a portion of the balloon, the coating including particles of a pharmaceutical agent, and each particle of the pharmaceutical agent is at least partially encapsulated in a polymer layer; positioning the device to allow the balloon to reach the target site; and inflating the balloon of the device.

公开(公告)号：AU2012326010B2

公开(公告)日：2017-05-11

申请号：AU2012326010

申请日：2012-10-18

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR CHARLES DOUGLAS ,  FAGAN MEGAN M

IPC: A61M31/00

Abstract: A medical device that releases a pharmaceutical agent to a target site is disclosed. The medical device includes a balloon, and a coating on at least a portion of the balloon. Each particle of the particles of the pharmaceutical agent is at least partially encapsulated in a polymer layer. The method includes the steps of providing a device including a balloon, and a coating on at least a portion of the balloon, the coating including particles of a pharmaceutical agent, and each particle of the pharmaceutical agent is at least partially encapsulated in a polymer layer; positioning the device to allow the balloon to reach the target site; and inflating the balloon of the device.

公开(公告)号：CA2841360A1

公开(公告)日：2013-01-24

申请号：CA2841360

申请日：2012-07-12

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR CHARLES DOUGLAS ,  ZANI BRETT G ,  NEET JOHN ,  KIORPES TIMOTHY CHARLES

IPC: A61F2/06

Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.

公开(公告)号：CA2852260C

公开(公告)日：2020-09-22

申请号：CA2852260

申请日：2012-10-18

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR CHARLES DOUGLAS ,  FAGAN MEAGAN M

IPC: A61L29/08 ,  A61K9/00 ,  A61K31/436 ,  A61L29/16 ,  A61M31/00

Abstract: A medical device that releases a pharmaceutical agent to a target site is disclosed. The medical device includes a balloon, and a coating on at least a portion of the balloon. Each particle of the particles of the pharmaceutical agent is at least partially encapsulated in a polymer layer. The method includes the steps of providing a device including a balloon, and a coating on at least a portion of the balloon, the coating including particles of a pharmaceutical agent, and each particle of the pharmaceutical agent is at least partially encapsulated in a polymer layer; positioning the device to allow the balloon to reach the target site; and inflating the balloon of the device.

公开(公告)号：AU2014248508B2

公开(公告)日：2018-11-08

申请号：AU2014248508

申请日：2014-03-12

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR CHARLES DOUGLAS ,  BURGERMEISTER ROBERT STEVEN

IPC: A61F2/00

Abstract: A bioabsorbable biomedical implant is disclosed. The implant includes a tubular scaffold comprising a plurality of interconnected polymer struts. The interconnected polymer struts defines a plurality of deformable cells. The polymer struts have an average strut thickness of no more than about 120 μιη. Methods for making the bioabsorbable biomedical implant, including the methods for making the polymer materials for the tubular scaffold, are also disclosed.