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    PROLONGED DRUG-ELUTING PRODUCTS
    1.
    发明专利
    PROLONGED DRUG-ELUTING PRODUCTS 未知

    公开(公告)号：CA2977289A1

    公开(公告)日：2018-03-23

    申请号：CA2977289

    申请日：2017-08-22

    Applicant: MICELL TECHNOLOGIES INC

    Inventor： KIORPES TIMOTHY CHARLES ,  MCCLAIN JAMES B

    IPC: A61L31/16 ,  A61K9/00 ,  A61K47/34 ,  A61L27/50 ,  A61L27/54 ,  A61L31/14

    Abstract: A drug-eluting product is disclosed comprising an at least partially bioabsorbable element and an active pharmaceutical agent having a morphology, a solubility, and an average particle size which are selected so that the active pharmaceutical agent continues to dissolve during the biodegradation of the bioabsorbable element. The morphology is a crystalline, semi-crystalline or amorphous morphology, the solubility is less than 100 µg/ml and the average particle size is grater that about 100 nm.

    PROLONGED DRUG-ELUTING PRODUCTS
    2.
    发明专利
    PROLONGED DRUG-ELUTING PRODUCTS 未知

    公开(公告)号：AU2017219090A1

    公开(公告)日：2018-04-12

    申请号：AU2017219090

    申请日：2017-08-25

    Applicant: MICELL TECHNOLOGIES INC

    Inventor： KIORPES TIMOTHY CHARLES ,  MCCLAIN JAMES B

    IPC: A61L27/28 ,  A61K31/00 ,  A61K38/00 ,  A61K47/00

    Abstract: A drug-eluting product is disclosed comprising an at least partially bioabsorbable element and an active pharmaceutical agent having a morphology, a solubility, and an average particle size which are selected so that the active pharmaceutical agent continues to dissolve during the biodegradation of the bioabsorbable element. The morphology is a crystalline, semi-crystalline or amorphous morphology, the solubility is less than 100 ptg/ml and the average particle size is grater that about 100 nm.

    DRUG DELIVERY MEDICAL DEVICE
    3.
    发明专利
    DRUG DELIVERY MEDICAL DEVICE 未知

    公开(公告)号：CA2841360A1

    公开(公告)日：2013-01-24

    申请号：CA2841360

    申请日：2012-07-12

    Applicant: MICELL TECHNOLOGIES INC

    Inventor： MCCLAIN JAMES B ,  TAYLOR CHARLES DOUGLAS ,  ZANI BRETT G ,  NEET JOHN ,  KIORPES TIMOTHY CHARLES

    IPC: A61F2/06

    Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.

    NANOPARTICLE AND SURFACE-MODIFIED PARTICULATE COATINGS, COATED BALLOONS, AND METHODS THEREFORE
    4.
    发明专利
    NANOPARTICLE AND SURFACE-MODIFIED PARTICULATE COATINGS, COATED BALLOONS, AND METHODS THEREFORE 未知

    公开(公告)号：CA2823355C

    公开(公告)日：2017-08-22

    申请号：CA2823355

    申请日：2011-12-29

    Applicant: MICELL TECHNOLOGIES INC

    Inventor： MCCLAIN JAMES B ,  TAYLOR CHARLES DOUGLAS ,  ZANI BRETT G ,  KIORPES TIMOTHY CHARLES

    IPC: A61L29/16 ,  A61K31/436 ,  A61L29/08 ,  A61M31/00

    Abstract: Devices, coatings, and methods therefore comprise a medical device for delivering nanoparticles of an active agent to a treatment site. A coating on the medical device comprises active agent nanoparticles, which delivers coating to the treatment site and releases active agent nanoparticles into the treatment site over at least one day. A coating may comprise a polymer, a surfactant, and the nanoparticles. The coating may be prepared by forming a nanoemulsion. A coating may comprise encapsulated active agent nanoparticles which comprise active agent nanoparticles encapsulated in a polymer. The coating may have a positive surface charge. The coating may deliver active agent nanoparticles into the treatment site over at least about one day. The coating may be formed of a surfactant and nanoparticles mixture. The active agent nanoparticles may be deposited on the medical device using electrostatic capture.

    DRUG DELIVERY MEDICAL DEVICE
    6.
    发明专利
    DRUG DELIVERY MEDICAL DEVICE 未知

    公开(公告)号：CA2805631C

    公开(公告)日：2018-07-31

    申请号：CA2805631

    申请日：2011-07-15

    Applicant: MICELL TECHNOLOGIES INC

    Inventor： MCCLAIN JAMES B ,  TAYLOR CHARLES DOUGLAS ,  ZANI BRETT G ,  NEET JOHN ,  KIORPES TIMOTHY CHARLES

    IPC: A61L29/08 ,  A61K9/00 ,  A61K31/436 ,  A61L29/16 ,  A61M31/00

    Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.

    NANOPARTICLE AND SURFACE-MODIFIED PARTICULATE COATINGS, COATED BALLOONS, AND METHODS THEREFORE
    7.
    发明专利
    NANOPARTICLE AND SURFACE-MODIFIED PARTICULATE COATINGS, COATED BALLOONS, AND METHODS THEREFORE 未知

    公开(公告)号：CA2823355A1

    公开(公告)日：2012-07-05

    申请号：CA2823355

    申请日：2011-12-29

    Applicant: MICELL TECHNOLOGIES INC

    Inventor： MCCLAIN JAMES B ,  TAYLOR CHARLES DOUGLAS ,  ZANI BRETT G ,  KIORPES TIMOTHY CHARLES

    IPC: A61K9/00 ,  A61K31/436 ,  B05D7/00 ,  B82Y5/00

    Abstract: Devices, coatings, and methods therefore comprise a medical device for delivering nanoparticles of an active agent to a treatment site. A coating on the medical device comprises active agent nanoparticles, which delivers coating to the treatment site and releases active agent nanoparticles into the treatment site over at least one day. A coating may comprise a polymer, a surfactant, and the nanoparticles. The coating may be prepared by forming a nanoemulsion. A coating may comprise encapsulated active agent nanoparticles which comprise active agent nanoparticles encapsulated in a polymer. The coating may have a positive surface charge. The coating may deliver active agent nanoparticles into the treatment site over at least about one day. The coating may be formed of a surfactant and nanoparticles mixture. The active agent nanoparticles may be deposited on the medical device using electrostatic capture.

    DRUG DELIVERY MEDICAL DEVICE
    8.
    发明专利
    DRUG DELIVERY MEDICAL DEVICE 未知

    公开(公告)号：CA2805631A1

    公开(公告)日：2012-01-19

    申请号：CA2805631

    申请日：2011-07-15

    Applicant: MICELL TECHNOLOGIES INC

    Inventor： MCCLAIN JAMES B ,  TAYLOR CHARLES DOUGLAS ,  ZANI BRETT G ,  NEET JOHN ,  KIORPES TIMOTHY CHARLES

    IPC: A61L29/08 ,  A61K9/00 ,  A61K31/436 ,  A61L29/16 ,  A61M31/00

    Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.

    NANOPARTICLE AND SURFACE-MODIFIED PARTICULATE COATINGS, COATED BALLOONS, AND METHODS THEREFORE
    9.
    发明申请
    NANOPARTICLE AND SURFACE-MODIFIED PARTICULATE COATINGS, COATED BALLOONS, AND METHODS THEREFORE 审中-公开
    纳米颗粒和表面改性颗粒涂料，包覆气泡及其方法

    公开(公告)号：WO2012092504A2

    公开(公告)日：2012-07-05

    申请号：PCT/US2011067921

    申请日：2011-12-29

    Applicant: MICELL TECHNOLOGIES INC ,  MCCLAIN JAMES B ,  TAYLOR CHARLES DOUGLAS ,  ZANI BRETT G ,  KIORPES TIMOTHY CHARLES

    Inventor： MCCLAIN JAMES B ,  TAYLOR CHARLES DOUGLAS ,  ZANI BRETT G ,  KIORPES TIMOTHY CHARLES

    IPC: A61K9/00 ,  A61K31/436 ,  A61P37/06 ,  B05D7/00 ,  B82Y5/00

    CPC classification number: B82Y5/00 ,  A61K31/436 ,  A61L29/085 ,  A61L29/143 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/624 ,  A61L2300/802 ,  A61L2400/12

    Abstract: Devices, coatings, and methods therefore comprise a medical device for delivering nanoparticles of an active agent to a treatment site. A coating on the medical device comprises active agent nanoparticles, which delivers coating to the treatment site and releases active agent nanoparticles into the treatment site over at least one day. A coating may comprise a polymer, a surfactant, and the nanoparticles. The coating may be prepared by forming a nanoemulsion. A coating may comprise encapsulated active agent nanoparticles which comprise active agent nanoparticles encapsulated in a polymer. The coating may have a positive surface charge. The coating may deliver active agent nanoparticles into the treatment site over at least about one day. The coating may be formed of a surfactant and nanoparticles mixture. The active agent nanoparticles may be deposited on the medical device using electrostatic capture.

    Abstract translation: 因此，装置，涂层和方法包括用于将活性剂的纳米颗粒递送到治疗部位的医疗装置。 医疗装置上的涂层包括活性剂纳米颗粒，其将涂层递送至治疗部位并在至少一天内将活性剂纳米颗粒释放到治疗部位。 涂层可以包括聚合物，表面活性剂和纳米颗粒。 可以通过形成纳米乳液来制备涂层。 涂层可以包含包封在聚合物中的活性剂纳米颗粒的包封的活性剂纳米颗粒。 涂层可能具有正表面电荷。 涂层可在至少约一天内将活性剂纳米颗粒递送至治疗部位。 涂层可以由表面活性剂和纳米颗粒混合物形成。 活性剂纳米颗粒可以使用静电捕获沉积在医疗装置上。

    DRUG DELIVERY MEDICAL DEVICE
    10.
    发明申请
    DRUG DELIVERY MEDICAL DEVICE 审中-公开
    药物递送医疗设备

    公开(公告)号：WO2012009684A3

    公开(公告)日：2012-04-19

    申请号：PCT/US2011044263

    申请日：2011-07-15

    Applicant: MICELL TECHNOLOGIES INC ,  MCCLAIN JAMES B ,  TAYLOR DOUGLAS ,  ZANI BRETT G ,  NEET JOHN ,  KIORPES TIMOTHY CHARLES

    Inventor： MCCLAIN JAMES B ,  TAYLOR DOUGLAS ,  ZANI BRETT G ,  NEET JOHN ,  KIORPES TIMOTHY CHARLES

    IPC: A61F2/06

    CPC classification number: A61M25/10 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61M25/1011

    Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.

    Abstract translation: 提供一种涂覆的可植入医疗装置，包括：基底; 以及涂层，其设置在所述基底上，其中所述涂层包含至少一种聚合物和至少一种治疗期望形态的药剂和/或至少一种活性生物剂和任选的一种或多种药物载体; 其中基本上所有的药剂和/或活性生物制剂都保留在涂层内和衬底上，直到可植入装置部署在受试者身体内部的介入部位，并且其中在将医疗装置部署在受试者的身体中时 一部分药剂和/或活性生物剂在干预部位与至少一部分聚合物和/或药物载体的至少一部分一起递送。

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