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    Implantable nasal stimulator systems and methods
    12.
    发明专利
    Implantable nasal stimulator systems and methods 未知

    公开(公告)号：AU2015335774B2

    公开(公告)日：2020-07-16

    申请号：AU2015335774

    申请日：2015-10-22

    Applicant: OCULEVE INC

    Inventor： FRANKE MANFRED ,  LOUDIN JAMES DONALD ,  KUZMA JANUSZ ,  YUN PAUL TAEHYUN ,  ACKERMANN DOUGLAS MICHAEL

    IPC: A61N1/36

    Abstract: Described here are systems, devices, and methods for implanting a nasal stimulator into nasal tissue and electrically stimulating nasal tissue. In some variations, a nasal microstimulator implantation system may comprise an implantation tool and an implantable microstimulator. An implantation tool may comprise a shaft and features to releasably attach a microstimulator. A microstimulator may comprise a passive stimulation circuit and one or more electrodes. In other variations, a nasal implantation system may additionally comprise one or more additional devices, such as a controller, an electrical probe, and/or a dissection tool.

    Dispositivos de estimulación
    14.
    发明专利
    Dispositivos de estimulación 未知

    公开(公告)号：ES2645204T3

    公开(公告)日：2017-12-04

    申请号：ES12768458

    申请日：2012-04-06

    Applicant: OCULEVE INC ,  UNIV LELAND STANFORD JUNIOR

    Inventor： ACKERMANN DOUGLAS MICHAEL ,  LOUDIN JAMES DONALD ,  KUZMA JANUSZ ,  PALANKER DANIEL ,  WETENKAMP SCOTT FRANKLIN

    IPC: A61N1/372 ,  A61N1/05 ,  A61N1/36

    Abstract: Sistema (2100) para tratar estados del ojo que comprende: un microestimulador implantable (2106, 3502, 4200) configurado para generar una señal de estimulación, que comprende un alojamiento (4202) que comprende un circuito de estimulación pasivo y una conexión interfacial; y una extensión flexible (4204) conectada al alojamiento y que comprende al menos un electrodo (4206), en el que la extensión flexible comprende un componente moldeado que tiene un grosor que es mayor que un grosor del alojamiento o menor que el grosor del alojamiento y que se estrecha hasta el grosor del alojamiento o que tiene un grosor que el igual que el grosor del alojamiento, y en el que el electrodo puede conectarse al circuito de estimulación pasivo a través de la conexión interfacial; un controlador portátil (2102, 2104) configurado para producir una señal de salida para proporcionar energía al microestimulador, en el que al menos uno de una amplitud, ancho de pulso o frecuencia de pulso de la señal de estimulación depende de al menos uno de una amplitud, ancho de pulso o frecuencia de pulso de la señal de salida; y un dispositivo de inserción (3500) configurado para sujetar de manera liberable el microestimulador cerca de un extremo distal del dispositivo de inserción.

    CONTACT LENS FOR INCREASING TEAR PRODUCTION
    15.
    发明专利
    CONTACT LENS FOR INCREASING TEAR PRODUCTION 未知

    公开(公告)号：CA2965514A1

    公开(公告)日：2016-04-28

    申请号：CA2965514

    申请日：2015-10-22

    Applicant: OCULEVE INC

    Inventor： LOUDIN JAMES DONALD ,  FRANKE MANFRED ,  HAMILTON DANIEL N ,  DORAISWAMY ANAND ,  ACKERMANN DOUGLAS MICHAEL

    IPC: A61N1/36

    Abstract: Described here are devices, systems, and methods for increasing tear production by stimulating the cornea, conjunctiva, and/or subconjunctiva. In some variations, the devices may be in the form of a contact lens. The contact lens may comprise a lens body and a stimulator chip, where the stimulator chip is embedded in the lens body. An external power source wirelessly transmits energy to the stimulator chip, where the stimulator chip may convert the energy to an electric waveform to stimulate the cornea, conjunctiva, and/or subconjunctiva. Stimulation may activate the lacrimal reflex to increase tear production. The devices and systems for increasing tear production may be used in methods of treating dry eye, reducing the symptoms of tired eye, increasing comfort for contact lens wearers, and extending the number of years a contact lens user can wear contacts. Also described are methods of manufacturing a contact lens.

    IMPLANTABLE NASAL STIMULATOR SYSTEMS AND METHODS
    16.
    发明专利
    IMPLANTABLE NASAL STIMULATOR SYSTEMS AND METHODS 未知

    公开(公告)号：CA2965363A1

    公开(公告)日：2016-04-28

    申请号：CA2965363

    申请日：2015-10-22

    Applicant: OCULEVE INC

    Inventor： FRANKE MANFRED ,  LOUDIN JAMES DONALD ,  KUZMA JANUSZ ,  YUN PAUL TAEHYUN ,  ACKERMANN DOUGLAS MICHAEL

    IPC: A61N1/36

    Abstract: Described here are systems, devices, and methods for implanting a nasal stimulator into nasal tissue and electrically stimulating nasal tissue. In some variations, a nasal microstimulator implantation system may comprise an implantation tool and an implantable microstimulator. An implantation tool may comprise a shaft and features to releasably attach a microstimulator. A microstimulator may comprise a passive stimulation circuit and one or more electrodes. In other variations, a nasal implantation system may additionally comprise one or more additional devices, such as a controller, an electrical probe, and/or a dissection tool.

    Contact lens for increasing tear production
    19.
    发明专利
    Contact lens for increasing tear production 未知

    公开(公告)号：AU2015335772B2

    公开(公告)日：2020-07-09

    申请号：AU2015335772

    申请日：2015-10-22

    Applicant: OCULEVE INC

    Inventor： LOUDIN JAMES DONALD ,  FRANKE MANFRED ,  HAMILTON DANIEL N ,  DORAISWAMY ANAND ,  ACKERMANN DOUGLAS MICHAEL

    IPC: A61N1/36

    Abstract: Described here are devices, systems, and methods for increasing tear production by stimulating the cornea, conjunctiva, and/or subconjunctiva. In some variations, the devices may be in the form of a contact lens. The contact lens may comprise a lens body and a stimulator chip, where the stimulator chip is embedded in the lens body. An external power source wirelessly transmits energy to the stimulator chip, where the stimulator chip may convert the energy to an electric waveform to stimulate the cornea, conjunctiva, and/or subconjunctiva. Stimulation may activate the lacrimal reflex to increase tear production. The devices and systems for increasing tear production may be used in methods of treating dry eye, reducing the symptoms of tired eye, increasing comfort for contact lens wearers, and extending the number of years a contact lens user can wear contacts. Also described are methods of manufacturing a contact lens.

    Extranasal stimulation devices and methods
    20.
    发明专利
    Extranasal stimulation devices and methods 未知

    公开(公告)号：AU2017366730A1

    公开(公告)日：2019-05-16

    申请号：AU2017366730

    申请日：2017-12-01

    Applicant: OCULEVE INC

    Inventor： FRANKE MANFRED ,  LIU CHAO ,  ACKERMANN DOUGLAS MICHAEL ,  SENCHYNA DIANE MICHELLE ,  LOUDIN JAMES DONALD

    IPC: A61B3/00 ,  A61B3/10 ,  A61B3/14 ,  A61B5/00 ,  A61F9/00 ,  A61F9/007 ,  A61N1/36

    Abstract: A stimulation system for treating a condition (e.g., dry eye, Meibomian gland disease) of a subject includes a stimulator configured to deliver a stimulus to external facial tissue of the subject, at least one sensor configured to detect a characteristic of the subject, and a control system in communication with the sensor and configured to adjust the stimulus at least partially based on the detected subject characteristic. In some variations, the control system may be configured to adjust the stimulus at least partially based on a detected environmental condition. The stimulator may be configured to activate a nerve of the subject, thereby increasing tear production. The stimulation system may, for example, include a device configured to be worn by a subject such as eyeglasses or a mask, or held by a subject such as handheld stimulator device.

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