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公开(公告)号：CA2874756C
公开(公告)日：2018-05-29
申请号：CA2874756
申请日：2008-03-27
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , VERNER ERIK , BUGGY JOSEPH J , LOURY DAVID , CHEN WEI
IPC: C07D487/04 , A61K31/519 , A61P19/02 , A61P29/00 , A61P37/06 , C12N9/12 , C12Q1/48 , G01N33/53
Abstract: Described herein are irreversible kinase inhibitor compounds, methods for synthesizing such irreversible inhibitors, and methods for using such irreversible inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate irreversible inhibitor of a protein, including a kinase.
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12.发明专利
公开(公告)号：ES2627820T3
公开(公告)日：2017-07-31
申请号：ES11872389
申请日：2011-09-13
Applicant: PHARMACYCLICS INC
Inventor： LOURY DAVID , BUGGY JOSEPH , MODY TARAK , VERNER ERIK , PURRO NORBERT , BALASUBRAMANIAN SRIRAM , KLOOS IOANA , DEPIL STÉPHANE
IPC: A61K31/343 , A61K31/16 , A61K31/166 , A61P35/00
Abstract: Una combinación de bendamustina, o su sal de clorhidrato, y el Compuesto 1: Compuesto 1 o una sal **Fórmula** farmacéuticamente aceptable del mismo.
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公开(公告)号：BRPI0810086A2
公开(公告)日：2016-07-26
申请号：BRPI0810086
申请日：2008-03-27
Applicant: PHARMACYCLICS INC
Inventor： LOURY DAVID , VERNER ERIK , BUGGY JOSEPH J , HONIGBERG LEE , CHEN WEI
IPC: A61K31/52 , A61K31/519 , A61P29/00 , A61P35/00 , C07D253/06 , C07D473/34 , C07D487/04
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公开(公告)号：EA019258B1
公开(公告)日：2014-02-28
申请号：EA201000633
申请日：2008-10-16
Applicant: PHARMACYCLICS INC
Inventor： LOURY DAVID , PURRO NORBERT
Abstract: Предложенакомпозицияв форме, пригоднойдляподкожноговведениямлекопитающему, содержащаясоединениеформулы I илиегосоль, растворенныев воде, гидроксиднатрияи трометамин, иимеющаявеличинурНмеждупримерно 8,0 ипримерно 9,5. Композицияпредназначенадлялеченияракаи/илитромбоэмболическихнарушений. Такжепредложеноустройстводлявведениякомпозициипоизобретению, причемустройствовключаетшприц.
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公开(公告)号：CA2681756A1
公开(公告)日：2008-10-09
申请号：CA2681756
申请日：2008-03-27
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , CHEN WEI , VERNER ERIK , LOURY DAVID , BUGGY JOSEPH J
IPC: A61K31/52 , A61K31/519 , A61P29/00 , A61P35/00 , C07D253/06
Abstract: Described herein are irreversible kinase inhibitor compounds, methods for synthesizing such irreversible inhibitors, and methods for using such irrev ersible inhibitors in the treatment of diseases. Further described herein ar e methods, assays and systems for determining an appropriate irreversible in hibitor of a protein, including a kinase.
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Patent Agency Ranking
公开(公告)号：AU2008232762A1
公开(公告)日：2008-10-09
申请号：AU2008232762
申请日：2008-03-27
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , CHEN WEI , VERNER ERIK , LOURY DAVID , BUGGY JOSEPH J
IPC: A61K31/519 , A61K31/52 , A61P29/00 , A61P35/00 , C07D253/06 , C07D473/34 , C07D487/04
Abstract: (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one for use in treating a B-cell proliferative cancer.
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公开(公告)号：CA2681756C
公开(公告)日：2015-02-24
申请号：CA2681756
申请日：2008-03-27
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , VERNER ERIK , BUGGY JOSEPH J , LOURY DAVID , CHEN WEI
IPC: C07D487/04 , A61K31/519 , A61P29/00 , A61P37/06 , C12N9/12 , C12Q1/48
Abstract: Described herein are irreversible kinase inhibitor compounds, methods for synthesizing such irreversible inhibitors, and methods for using such irreversible inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate irreversible inhibitor of a protein, including a kinase.
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公开(公告)号：CA2730930C
公开(公告)日：2015-01-13
申请号：CA2730930
申请日：2009-07-16
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , VERNER ERIK , BUGGY JOSEPH , LOURY DAVID , CHEN WEI
Abstract: Described herein are irreversible Btk inhibitor compounds, and methods for using such irreversible inhibitors in the treatment of diseases and disorders characterized by the presence or development of solid tumors.
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公开(公告)号：MX2009010284A
公开(公告)日：2010-01-29
申请号：MX2009010284
申请日：2008-03-27
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , VERNER ERIK , BUGGY JOSEPH J , LOURY DAVID , CHEN WEI
IPC: A61K31/52 , A61K31/519 , A61P29/00 , A61P35/00 , C07D253/06 , C07D473/34 , C07D487/04
Abstract: En la presente se describen compuestos inhibidores de cinasa irreversibles, métodos para sintetizar dichos inhibidores irreversibles, y métodos para usar dichos inhibidores irreversibles en el tratamiento de enfermedades. En la presente se describen también métodos, ensayos y sistemas para determinar un inhibidor irreversible apropiado de una proteína, que incluye una cinasa.
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公开(公告)号：CA2702970A1
公开(公告)日：2009-04-23
申请号：CA2702970
申请日：2008-10-16
Applicant: PHARMACYCLICS INC
Inventor： LOURY DAVID , PURRO NORBERT
Abstract: Treatment of cancer and thromboembolic disorders using inhibitors of Factor VIIa are disclosed herein using a compound of Formula I.
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