公开(公告)号：EA020045B1

公开(公告)日：2014-08-29

申请号：EA200901442

申请日：2008-05-02

Applicant: PORTOLA PHARM INC

Inventor： CONLEY PAMELA B ,  ANDRE PATRICK ,  SINHA UMA

IPC: A61K31/235 ,  A61K31/422 ,  A61K31/435 ,  A61K31/517 ,  A61K45/06 ,  A61P7/00 ,  A61P7/02 ,  A61P9/00

Abstract: Изобретениеотноситсяк фармацевтическимкомпозициями способамкомбинированнойтерапии, включающейприменение [4-(6-фтор-7-метиламино-2,4-диоксо-1,4-дигидро-2Н-хиназолин-3-ил)фенил]-5-хлортиофен-2-илсульфонилмочевиныилиеефармацевтическиприемлемойсолии второготерапевтическогоагента, выбранногоизантикоагулянта, такогокакантителопротивфактора XI ибетриксабанилиегофармацевтическиприемлемаясоль, антитромботическогоагента, такогокакифетробан, илиихкомбинациидлялечениятромбозныхзаболеваний.

公开(公告)号：TN2009000444A1

公开(公告)日：2011-03-31

申请号：TN2009000444

申请日：2009-10-23

Applicant: PORTOLA PHARM INC

Inventor： CONLEY PAMELA B ,  ANDRE PATRICK ,  SINHA UMA

IPC: A61K31/235 ,  A61K31/422 ,  A61K31/435 ,  A61K31/517 ,  A61K45/06 ,  A61P7/00 ,  A61P7/02 ,  A61P9/00

公开(公告)号：ECSP099778A

公开(公告)日：2010-01-29

申请号：ECSP099778

申请日：2009-12-02

Applicant: PORTOLA PHARM INC

Inventor： PANDEY ANJALI ,  CONLEY PAMELA B ,  ANDRE PATRICK ,  GRETLER DANIEL D ,  HUTCHALEELAHA ATHIWAT ,  PHILLIPS DAVID R ,  SCARBOROUGH CARROLL ANNA CREW ,  WOLIN HUANG

IPC: A61K31/216 ,  A61K31/517 ,  A61P7/02

Abstract: Este invento brinda métodos y compuestos para una inhibición plaquetaria rápida y reversible en sujetos humanos que necesitan de la misma cuando se administran compuestos con la fórmula (I), Ya sea sola o en combinación con un segundo agente que puede ser aspirina o un agente trombolítico.

公开(公告)号：CA2686203A1

公开(公告)日：2008-11-13

申请号：CA2686203

申请日：2008-05-02

Applicant: PORTOLA PHARM INC

Inventor： CONLEY PAMELA B ,  ANDRE PATRICK ,  HUTCHALEELAHA ATHIWAT ,  PHILLIPS DAVID R ,  WOLIN HUANG ,  PANDEY ANJALI ,  GRETLER DANIEL D

IPC: A61K31/216 ,  A61K31/517 ,  A61P7/02

Abstract: The invention provides methods and compositions for rapid and reversible inhibition of platelet aggregation in human subjects in need thereof by admi nistering compounds of the formula: (I) alone or in combination with a secon d agent which can be aspirin or a thrombolytic agent.

公开(公告)号：AU2021218033A1

公开(公告)日：2021-09-09

申请号：AU2021218033

申请日：2021-08-17

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  PHILLIPS DAVID R ,  ANDRE PATRICK ,  SINHA UMA

IPC: A61P7/02 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/715 ,  A61K31/727 ,  A61K38/36 ,  A61K38/48 ,  A61K39/00 ,  A61K39/395 ,  A61P7/04 ,  C07H21/00 ,  C07K14/00 ,  C07K16/00 ,  C12N5/10 ,  C12N9/64 ,  C12P21/00

Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or 5 have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.

公开(公告)号：ES2597436T3

公开(公告)日：2017-01-18

申请号：ES08834136

申请日：2008-09-26

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  PHILLIPS DAVID R ,  ANDRE PATRICK ,  SINHA UMA

IPC: A61K38/48 ,  A61K39/00 ,  A61P7/04 ,  C12N9/64

Abstract: Un derivado de fXa que es un polipéptido aislado que comprende la secuencia de aminoácidos de la SEQ ID NO. 12.

公开(公告)号：CA2627719C

公开(公告)日：2016-07-12

申请号：CA2627719

申请日：2006-11-03

Applicant: PORTOLA PHARM INC

Inventor： HUANG WOLIN ,  MEHROTRA MUKUND ,  ZHANG XIAOMING ,  CANNON HILARY ,  GRANT CRAIG M ,  SCARBOROUGH ROBERT M ,  PANDEY ANJALI ,  CONLEY PAMELA B ,  ANDRE PATRICK ,  PHILLIPS DAVID R ,  SINHA UMA

IPC: C07D409/12 ,  A61K31/517 ,  A61P7/02 ,  A61P9/00 ,  C07C269/04 ,  C07C271/58 ,  C07D239/96

Abstract: The present invention provides novel sulfonylurea compounds of formula (I) and pharmaceutically acceptable derivatives and polymorph and amorphous forms thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also provides a method for preparing such compounds and forms and for preventing or treating thrombosis and thrombosis related conditions in a mammal comprising the step of administering a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or forms thereof.

公开(公告)号：AU2014210620B2

公开(公告)日：2016-05-12

申请号：AU2014210620

申请日：2014-08-07

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  PHILLIPS DAVID R ,  ANDRE PATRICK ,  SINHA UMA

IPC: A61P7/02 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/715 ,  A61K31/727 ,  A61K38/36 ,  A61K38/48 ,  A61K39/00 ,  A61K39/395 ,  A61K47/48 ,  A61P7/04 ,  C07H21/00 ,  C07K14/00 ,  C07K16/00 ,  C12N5/10 ,  C12N9/64 ,  C12P21/00

Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.

公开(公告)号：HK1210443A1

公开(公告)日：2016-04-22

申请号：HK15111214

申请日：2015-11-13

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  PHILLLIPS DAVID R ,  ANDRE PATRICK ,  SINHA UMA

IPC: A61P20060101 ,  A61K20060101 ,  A61K39/00

Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa.The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.

公开(公告)号：BRPI0811476A2

公开(公告)日：2014-11-04

申请号：BRPI0811476

申请日：2008-05-02

Applicant: PORTOLA PHARM INC

Inventor： SCARBOROUGH ROBERT M ,  GRETLER DANIEL D ,  CONLEY PAMELA B ,  ANDRE PATRICK ,  HUTCHALEELAHA ATHIWAT ,  PHILIPS DAVID R ,  PANDEY ANJALI ,  WOLIN HUANG

IPC: A61K31/216 ,  A61K31/517 ,  A61P7/02

Abstract: The invention provides methods and compositions for rapid and reversible inhibition of platelet aggregation in human subjects in need thereof by administering compounds of the formula: alone or in combination with a second agent which can be aspirin or a thrombolytic agent.